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11.
VG Osnabrück 《MedR Medizinrecht》2000,18(10):488-492
Ohne Zusammenfassung 相似文献
12.
WH Belloso LC Orellana B Grinsztejn JS Madero A La Rosa VG Veloso J Sanchez R Ismerio Moreira B Crabtree‐Ramirez O Garcia Messina MB Lasala J Peinado MH Losso 《HIV medicine》2010,11(9):554-564
Objective
Acquired immune deficiency appears to be associated with serious non‐AIDS (SNA)‐defining conditions such as cardiovascular disease, liver and renal insufficiency and non‐AIDS‐related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort.Materials and methods
Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV‐associated factors on non‐AIDS‐defining conditions.Results
Among 6007 patients in follow‐up, 130 had an SNA event (0.86 events/100 person‐years of follow‐up) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non‐AIDS‐defining malignancies and two with renal insufficiency). Risk factors such as diabetes, hepatitis B and C virus coinfections and alcohol abuse showed an association with events, as expected. The last recorded CD4 T‐cell count prior to index date (P=0.0056, with an average difference of more than 100 cells/μL) and area under the CD4 cell curve in the year previous to index date (P=0.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors.Conclusions
The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and the risk of SNA events, even in patients under antiretroviral treatment. 相似文献13.
14.
VG Sigmaringen 《MedR Medizinrecht》2003,21(2):119-121
Ohne Zusammenfassung 相似文献
15.
16.
Maturo VG; Zusmer NR; Gilson AJ; Smoak WM; Janowitz WR; Bear BE; Goddard J; Dick DE 《Radiology》1980,137(2):457-463
Innovations in design of a dedicated breast scanner resulted in automation of the scanning process, the production of high resolution images of the whole breast and an efficient mode of image review. The results of clinical evaluation of the prototype of this breast scanner investigating normal breasts as well as benign and malignant breast lesions are presented. 相似文献
17.
Sinisa Cikic Partha K Chandra Jarrod C Harman Ibolya Rutkai Prasad VG Katakam Jessie J Guidry Jeffrey M Gidday David W Busija 《Journal of cerebral blood flow and metabolism》2021,41(2):397
Sex differences in mitochondrial numbers and function are present in large cerebral arteries, but it is unclear whether these differences extend to the microcirculation. We performed an assessment of mitochondria-related proteins in cerebral microvessels (MVs) isolated from young, male and female, Sprague-Dawley rats. MVs composed of arterioles, capillaries, and venules were isolated from the cerebrum and used to perform a 3 versus 3 quantitative, multiplexed proteomics experiment utilizing tandem mass tags (TMT), coupled with liquid chromatography/mass spectrometry (LC/MS). MS data and bioinformatic analyses were performed using Proteome Discoverer version 2.2 and Ingenuity Pathway Analysis. We identified a total of 1969 proteins, of which 1871 were quantified by TMT labels. Sixty-four proteins were expressed significantly (p < 0.05) higher in female samples compared with male samples. Females expressed more mitochondrial proteins involved in energy production, mitochondrial membrane structure, anti-oxidant enzyme proteins, and those involved in fatty acid oxidation. Conversely, males had higher expression levels of mitochondria-destructive proteins. Our findings reveal, for the first time, the full extent of sexual dimorphism in the mitochondrial metabolic protein profiles of MVs, which may contribute to sex-dependent cerebrovascular and neurological pathologies. 相似文献
18.
VG Münster 《MedR Medizinrecht》1999,17(3):146-148
Ohne Zusammenfassung 相似文献
19.
VG Gelsenkirchen 《MedR Medizinrecht》1999,17(9):427-429
Ohne Zusammenfassung 相似文献
20.
VG Karlsruhe 《MedR Medizinrecht》1999,17(7):329-331
Ohne Zusammenfassung 相似文献