全文获取类型
收费全文 | 545720篇 |
免费 | 28404篇 |
国内免费 | 521篇 |
专业分类
耳鼻咽喉 | 6894篇 |
儿科学 | 17317篇 |
妇产科学 | 12706篇 |
基础医学 | 94560篇 |
口腔科学 | 12951篇 |
临床医学 | 49861篇 |
内科学 | 98375篇 |
皮肤病学 | 12185篇 |
神经病学 | 35683篇 |
特种医学 | 20897篇 |
外国民族医学 | 54篇 |
外科学 | 80393篇 |
综合类 | 7747篇 |
现状与发展 | 2篇 |
一般理论 | 111篇 |
预防医学 | 39946篇 |
眼科学 | 12240篇 |
药学 | 42153篇 |
1篇 | |
中国医学 | 1140篇 |
肿瘤学 | 29429篇 |
出版年
2021年 | 4079篇 |
2018年 | 5952篇 |
2017年 | 4299篇 |
2016年 | 5068篇 |
2015年 | 5614篇 |
2014年 | 7484篇 |
2013年 | 10967篇 |
2012年 | 16223篇 |
2011年 | 18077篇 |
2010年 | 10410篇 |
2009年 | 9213篇 |
2008年 | 16401篇 |
2007年 | 18217篇 |
2006年 | 17647篇 |
2005年 | 16965篇 |
2004年 | 16513篇 |
2003年 | 15854篇 |
2002年 | 15392篇 |
2001年 | 23015篇 |
2000年 | 23522篇 |
1999年 | 19359篇 |
1998年 | 5412篇 |
1997年 | 4495篇 |
1996年 | 4511篇 |
1995年 | 4272篇 |
1992年 | 14718篇 |
1991年 | 16156篇 |
1990年 | 16238篇 |
1989年 | 15890篇 |
1988年 | 14566篇 |
1987年 | 14416篇 |
1986年 | 13409篇 |
1985年 | 12924篇 |
1984年 | 9582篇 |
1983年 | 8178篇 |
1982年 | 4293篇 |
1979年 | 9163篇 |
1978年 | 6526篇 |
1977年 | 5285篇 |
1976年 | 5609篇 |
1975年 | 6749篇 |
1974年 | 7541篇 |
1973年 | 7285篇 |
1972年 | 6737篇 |
1971年 | 6412篇 |
1970年 | 6000篇 |
1969年 | 5556篇 |
1968年 | 5259篇 |
1967年 | 4691篇 |
1966年 | 4043篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
71.
Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema 总被引:1,自引:0,他引:1
Tine V. Karlsen Marika J. Karkkainen Kari Alitalo Helge Wiig 《The Journal of physiology》2006,574(2):583-596
To investigate the phenotypic consequences of a deranged lymphangiogenesis in relation to tissue fluid accumulation and the possible role of inflammation in the pathogenesis of lymphoedema, we measured determinants of transcapillary fluid filtration and inflammatory mediators in the interstitial fluid in genetically engineered Chy mice, a model for primary congenital lymphoedema (Milroy's disease). Although initial lymphatics were not present in dermis in any of the areas studied (fore paw, hind paw, thigh and back skin) interstitial fluid pressure ( P if ), measured with micropipettes, and tissue fluid volumes were significantly increased only in the areas with visible swelling – the fore and hind paw, whereas interstitial colloid osmotic pressure (COPif ) was increased in all the skin areas examined. A volume load of 15% of body weight resulted in a more pronounced increase in P if as well as a four-fold increase in interstitial fluid volume in Chy relative to wild-type (wt) mice, showing the quantitative importance of lymphatics for fluid homeostasis during acute perturbations. A similar level of proinflammatory markers in interstitial fluid in early established lymphoedema (3–4 months) in Chy and wt suggests that inflammation does not have a major pathogenetic role for the development of lymphoedema, whereas a reduced level of the immunomodulatory cytokine interleukin (IL)-4 may result in a reduced immunological defence ability and thus lead to the increase in inflammatory cytokines IL-2 and IL-6 observed at a later stage (11–13 months). Our data suggest that primary lymphoedema results in a high interstitial fluid protein concentration that does not induce an interstitial inflammatory reaction per se , and furthermore shows the paramount importance of the initial lymphatics in tissue fluid homeostasis, especially during perturbations of transcapillary fluid balance. 相似文献
72.
I. V. Shilova E. A. Krasnov E. I. Korotkova M. G. Nagaev A. N. Lukina 《Pharmaceutical Chemistry Journal》2006,40(12):660-662
Extracts of the above-ground part of meadowsweet (Filipendula ulmaria L. Maxim.) demonstrate a pronounced antioxidant activity. It is established that 70% and 95% ethanol extracts contain the
most active substances. Investigation of the chemical composition of the above-ground part of the plant and its 70% ethanol
extract by means of qualitative reactions, thin-layer chromatography, and paper chromatography showed the presence of various
phenolic compounds, including quercetin and its glycosides, dihydroquercetin, apigenin, rododendrol, esculetin, and m-hydroxybenzoic, salicylic, anisic, gallic, gentisic, ferulic, chlorogenic, and caffeic acids.
__________
Translated From Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 12, Pp. 22–24, December, 2006. 相似文献
73.
Pankaj Dabir Snehal Dabir B V Siva Prasad M V R Reddy 《Infection, genetics and evolution》2006,6(4):287-291
Molecular characterization of Wuchereria bancrofti is essential to develop suitable anti-filarial drugs and vaccines. We describe here isolation, sequence analysis and cloning of a partial cDNA of an enzyme superoxide dismutase from this parasite. The immunoscreening of a lambda zap W. bancrofti microfilarial (Mf) cDNA library with microfilaremic sera had resulted in the isolation of several seroreactive clones including, WbSOD. This clone contained a 309 bp insert and showed significant nucleotide and deduced amino acid sequence homologies to the superoxide dismutases of other nematode parasites. The antioxidant property of this enzyme may have important contribution in the defense mechanism of the parasite against host immune response. 相似文献
74.
75.
76.
Outcomes at 3 years of a prospective pilot study of Campath-1H and sirolimus immunosuppression for renal transplantation 总被引:2,自引:0,他引:2
Rolf N. Barth Christina A. Janus Christine A. Lillesand Nancy A. Radke John D. Pirsch Bryan N. Becker Luis A. Fernandez L. Thomas Chin Yolanda T. Becker Jon S. Odorico Anthony M. D''Alessandro Hans W. Sollinger Stuart J. Knechtle 《Transplant international》2006,19(11):885-892
Campath-1H (alemtuzumab) induction was used for renal transplantation in combination with sirolimus as immunosuppression. We previously reported a high (28%) rate of early rejection with this regimen, and now report 3-year outcomes. Twenty-nine patients were recipients of either deceased donor or non-HLA (Human Leukocyte Antigen) identical living donor primary renal allografts. Clinical parameters including infection, malignancy, kidney function, and kidney histology were followed prospectively for 3 years. Three-year cumulative graft and patient survival were 96% and 100%, respectively. Twenty patients were maintained on steroid-free immunosuppressive regimens, and 15 patients were maintained on monotherapy for immunosuppression (12 on sirolimus). No serious infectious complications were observed and two patients developed basal cell skin cancer. The 3-year results of our initial pilot study demonstrate good graft (96%) and patient (100%) outcomes. Campath-1H induction has yielded a high proportion of patients maintained on immunosuppressive monotherapy (57%) without serious infectious- and no malignancy-related complications. The reported regimen yielded novel insights into both Campath-1H and sirolimus therapy in renal transplantation. Because of the higher incidence of early rejection, we recommend a modified strategy of immunosuppression including a brief course of a calcineurin inhibitor. 相似文献
77.
OBJECTIVE: This study was conducted to compare an otolaryngologist's experience with a cohort of epilepsy patients implanted with a vagal nerve stimulator (VNS) to previously published data. METHODS: Demographics, preoperative seizure frequency, medications, and complications were retrospectively collected from patients implanted by the senior author. Postoperative medications and seizure frequency were obtained from referring neurologists. RESULTS: Seventeen patients were implanted over a 24-month period. Average age was 28.3 years. Patients presented with petit mal (n = 3), tonic-clonic (n = 6), complex partial (n = 5), and grand mal (n = 8) seizures. Mean follow-up postimplantation was 13.5 months. Most patients had at least a 50% reduction of seizure frequency, with 3 patients being seizure free. There were no postoperative infections. One patient had left vocal cord immobility. The most common side effect was voice disturbance during device activation. CONCLUSION: Otolaryngologists are well equipped to perform VNS implantation and to diagnose and treat possible laryngeal side effects. EBM rating: C-4. 相似文献
78.
S. V. Terent’eva E. N. Komarova T. N. Sapozhnikova A. T. Teplyakov E. A. Ivanovskaya T. I. Andreeva 《Pharmaceutical Chemistry Journal》2006,40(12):694-696
A rapid procedure for determining angiotensin II in the blood by inverse voltammetry using a TA-2 device (Tekhnoanalit Company,
Tomsk) with a graphite electrode has been developed. The results of analyses using the proposed technique agree with the clinical
data. The rapid analytical procedure favors optimization of cardiotropic drug therapy.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 12, pp. 54–56, December, 2006. 相似文献
79.
80.