全文获取类型
收费全文 | 3290篇 |
免费 | 153篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 52篇 |
妇产科学 | 65篇 |
基础医学 | 339篇 |
口腔科学 | 112篇 |
临床医学 | 234篇 |
内科学 | 811篇 |
皮肤病学 | 23篇 |
神经病学 | 320篇 |
特种医学 | 89篇 |
外科学 | 699篇 |
综合类 | 9篇 |
预防医学 | 131篇 |
眼科学 | 20篇 |
药学 | 127篇 |
中国医学 | 3篇 |
肿瘤学 | 415篇 |
出版年
2024年 | 3篇 |
2023年 | 18篇 |
2022年 | 41篇 |
2021年 | 102篇 |
2020年 | 66篇 |
2019年 | 102篇 |
2018年 | 87篇 |
2017年 | 91篇 |
2016年 | 75篇 |
2015年 | 106篇 |
2014年 | 121篇 |
2013年 | 188篇 |
2012年 | 249篇 |
2011年 | 225篇 |
2010年 | 143篇 |
2009年 | 152篇 |
2008年 | 224篇 |
2007年 | 213篇 |
2006年 | 206篇 |
2005年 | 212篇 |
2004年 | 186篇 |
2003年 | 168篇 |
2002年 | 137篇 |
2001年 | 35篇 |
2000年 | 8篇 |
1999年 | 25篇 |
1998年 | 28篇 |
1997年 | 25篇 |
1996年 | 24篇 |
1995年 | 13篇 |
1994年 | 14篇 |
1993年 | 13篇 |
1992年 | 16篇 |
1991年 | 8篇 |
1990年 | 9篇 |
1989年 | 12篇 |
1988年 | 6篇 |
1987年 | 16篇 |
1986年 | 13篇 |
1985年 | 6篇 |
1984年 | 11篇 |
1983年 | 7篇 |
1982年 | 9篇 |
1981年 | 7篇 |
1980年 | 14篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1974年 | 3篇 |
1973年 | 3篇 |
排序方式: 共有3475条查询结果,搜索用时 15 毫秒
21.
Santarossa Sandra Vaccher Emanuela Balestreri Luca Volpe Rachele Tirelli Umberto 《Journal of neuro-oncology》1997,35(2):141-143
Patients with locally advanced transitional cell carcinoma (TCC)of the bladder are at high risk forsystemic relapse, with liver, bone and lung beingthe commonest sites of metastases.We report the case of a 52-year-old womanwith a solitary meningeal relapse, a rare siteof recurrence, after 8 months of complete remissionobtained with M-VEC for locally advanced TCC ofthe bladder. We speculate on the likely riskfactors related to this unusual site of recurrence. 相似文献
22.
23.
Roberto Orecchia Umberto Veronesi Patrick Maisonneuve Viviana Enrica Galimberti Roberta Lazzari Paolo Veronesi Barbara Alicja Jereczek-Fossa Federica Cattani Claudia Sangalli Alberto Luini Pietro Caldarella Marco Venturino Daniele Sances Stefano Zurrida Giuseppe Viale Maria Cristina Leonardi Mattia Intra 《The lancet oncology》2021,22(5):597-608
24.
Although mild-to-moderate intellectual disability is usually considered part of WAGR syndrome (Wilms' tumour (WT), Aniridia, Genital abnormalities, and metal Retardation, due to 11p13 deletion) the neuropsychological profile of the syndrome is little reported in the literature. We report about a 12-year-old boy presenting with WAGR syndrome (WT, right complete aniridia, bilateral cryptorchidism, interstitial deletion involving band 11p13) but with no mental retardation. An in-depth clinical evaluation revealed no behavioural or social problems and the child's neuropsychological profile was found to be within the normal range for all abilities and functions investigated (with the exception of an impulsive cognitive style and some difficulties in academic skills). This case underlines the importance of in-depth neuropsychological evaluation that includes not only IQ measurement, but also examination of attention and academic skills, in order to establish the complete phenotypical profile of WAGR patients, rather than labelling them as learning disabled (i.e. mental retardation). 相似文献
25.
Milena Villarini Sara Levorato Tania Salvatori Elisabetta Ceretti Sara Bonetta Annalaura Carducci Tiziana Grassi Samuele Vannini Francesco Donato Silvia Bonetta Marco Verani Antonella de Donno Silvia Bonizzoni Alberto Bonetti Massimo Moretti Umberto Gelatti 《International journal of hygiene and environmental health》2018,221(6):883-892
Background
Recent data support the hypothesis that genetic damage occurring early in life during childhood can play an important role in the development of chronic diseases in adulthood, including cancer.Objectives
The objective of this paper, part of the MAPEC_LIFE project, is to describe the frequency of micronuclei and meta-nuclear alterations in exfoliated buccal cells of 6–8year-old Italian children recruited in five Italian towns (i.e., Brescia, Torino, Pisa, Perugia and Lecce) with different air pollution levels.Methods
About 200 children per town were recruited from primary schools. Biological samples were collected twice from the same children, in two different seasons (winter 2014-15 and late spring 2015). Cytogenetic damage was evaluated by the buccal micronucleus cytome assay.Results
Overall,n?=?1046 children represent the final cohort of the MAPEC_LIFE study. On the whole, the results showed a higher mean MN frequency in winter (0.42?±?0.54‰) than late-spring (0.22?±?0.34‰). MN frequency observed among the five Italian towns showed a trend that follows broadly the levels of air pollution in Italy: the highest MN frequency was observed in Brescia during both seasons, the lowest in Lecce (winter) and Perugia (late-spring).Conclusions
To the best of our knowledge, the number of recruited children included in the analysis (n?=?1046) is the highest compared to previous studies evaluating the frequency of MN in exfoliated buccal cells so far. MN frequency was associated with winter season and living in towns at various levels of air pollution, suggesting an important role of this exposure in determining early cytogenetic effects. 相似文献26.
27.
Filaci G Fravega M Setti M Traverso P Millo E Fenoglio D Negrini S Ferrera F Romagnoli A Basso M Contini P Rizzi M Ghio M Benatti U Damonte G Ravetti JL Carmignani G Zanetti M Indiveri F 《Blood》2006,107(4):1505-1512
Telomerase is considered a universal tumor-associated antigen (TAA) due to its high rate of expression by cancers (approximately 90%), and clinical trials are in progress to test the immunotherapeutical efficacy of antitelomerase immunization in patients with cancer. However, the data concerning frequency and functional activity of telomerase-specific cytotoxic T lymphocytes (CTLs) in patients with cancer are few and conflicting, although their knowledge would be mandatory to predict the efficacy of telomerase-specific immunotherapy in selected patients. We performed this study to analyze frequency and cytolytic function of circulating CD8+ T lymphocytes specific for the p540 telomerase peptide in a series of human leukocyte antigen (HLA)-A2+ cancer patients. The results show that most patients with cancer have circulating telomerase-specific CD8+ T lymphocytes, but a high frequency of telomerase-specific CTLs are present only in a fraction of them. Furthermore, CTL lines able to kill telomerase-positive tumor cells, including autologous cancer cells, can be expanded ex vivo from some, but not all, patients with cancer. In conclusion, the results of the study support the development of clinical protocols using telomerase peptides as an immunizing agent. However, they underline the necessity to study single patients immunologically before undergoing vaccination, to select the patients adequately, and to eventually adapt the immunization schedule to the patient's immunologic status. 相似文献
28.
Michael J. Klingler Stephen K. Babitz Alexander Kutikov Riccardo Campi Georgios Hatzichristodoulou Francesco Sanguedolce Sabine Brookman-May Bulent Akdogan Umberto Capitanio Marco Roscigno Alessandro Volpe Martin Marszalek Robert G. Uzzo Alessandro Antonelli Johan Langenhuijsen Marco Carini Andrea Minervini Brian R. Lane 《Urologic oncology》2019,37(1):33-39
Purpose
Partial nephrectomy (PN) is standard for small renal masses, improving renal function by preserving renal parenchyma compared with radical nephrectomy. Recent work demonstrated that postoperative surgeon assessment of volume preservation (SAVP) and 3D imaging measurements agree and correlate with postoperative function. We hypothesize preoperative assessment of volume preservation (PAVP) with PN based on preoperative imaging will reliably indicate postoperative renal function.Materials and Methods
Data were collected from 336 patients undergoing PN for suspected renal cancer by 40 surgeons at 12 centers in Europe and the United States within the Surface-Intermediate-Base International Consortium. Surgeons recorded PAVP and SAVP for individual patients; pre- and postoperative glomerular filtration rate (GFR) was estimated by Chronic Kidney Disease Epidemiology Collaboration equations. Correlations between PAVP, SAVP, and postoperative GFR were assessed with linear regression models. Bland–Altman analysis was used to assess agreement between PAVP and SAVP with a significant cutoff of 5%.Results
Median PAVP was 90% (interquartile range [IQR] 85%–100%) and SAVP was 90% (IQR: 80%–94%). PAVP and SAVP were moderately correlated (R2?=?0.67, P < 0.0001) and deemed “interchangeable” by Bland–Altman analysis at a 5% acceptable rate of difference (95% CI: ?5.4, ?3.1). Median postoperative GFR was 77.3 (IQR: 56.2, 92.0). Both PAVP (R2?=?0.82, P < 0.0001) and SAVP (R2?=?0.83, P < 0.0001) were correlated with postoperative GFR. Multivariable models utilizing volume-adjusted GFR based on PAVP or SAVP significantly and similarly predicted postoperative GFR (R2?=?0.72 for each).Conclusion
Renal function is closely linked to the amount of parenchymal volume preservation, whether estimated prior to surgery (PAVP) or afterward (SAVP). PAVP provides reasonably accurate information for decision-making in patients considering PN. 相似文献29.
30.
Gentilucci UV Picardi A Manfrini S Khazrai YM Fioriti E Altomare M Guglielmi C Di Stasio E Pozzilli P 《Diabetes/metabolism research and reviews》2008,24(5):364-370
BACKGROUND: Aims of the present study were to examine the anthropometrical and metabolic characteristics of the Filipino population migrant to the Southern European city of Rome, Italy. METHODS: A cross-sectional study was carried out in the city of Rome. Three hundred thirty-five Filipinos (95 M/240 F, mean age: 44.0+/-9.8 years, mean residence in Italy: 12.9+/-6.3 years) were studied. Data were collected by standardized questionnaires; anthropometrical parameters, arterial pressure, and fasting capillary blood glucose (FCG) were measured. RESULTS: Abdominal obesity was found in 52.5%, and BMI >or= 25 kg/m(2) in 44.5% of subjects. History of type 2 diabetes mellitus (T2DM) and hypertension were reported by 6.0 and 9.0% of subjects, respectively. Impaired fasting glucose was found in 13.1%, and FCG >or= 110 mg/dl in 18.5% of subjects. Altered systolic and/or diastolic blood pressure was found in 34.3% of subjects. About three-fourths of subjects were unaware of being diabetic and/or hypertensive. Years of Italy residence showed a direct significant correlation with the degree of changes in alimentary behaviours (rho=0.18, p=0.001), and with weight gain (rho=0.27, p<0.001). Multivariate analysis showed only age and waist circumference to be associated with both diabetes and hypertension. CONCLUSIONS: In the present study, the first to examine the metabolic disorders in a migrant Filipino population resident in Rome, a high prevalence of obesity, diabetes, and hypertension was found. The alarming results emerging from this study should be seriously considered by public health practitioners and decision makers, and made known to the Filipinos resident in Europe. 相似文献