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91.
LN Barlow-Mosha DS Bagenda PK Mudiope MC Mubiru LM Butler MG Fowler PM Musoke 《African health sciences》2012,12(3):249-258
Background
Access to pediatric antiretroviral formulations is increasing in resource-limited countries, however adult FDCs are still commonly used by antiretroviral therapy (ART) programs.Objective
To describe long-term effectiveness of using adult FDC of d4T+3TC+NVP (Triomune) in children for HIV treatment.Methods
Clinical, immunologic, and virologic outcomes of HIV-infected ART-naïve children aged six months to 12 years, were evaluated up to 96 weeks post-ART initiation.Results
From March 2004 to June 2006, 104 children were followed with a median age of 5.4 years, median CD4 cell percent and HIV-1 RNA were 11.0% (IQR 6.7–13.9) and 348,846copies/mL (IQR 160,941–681,313) respectively at baseline. Using Kaplan-Meir estimates, 75% of children had undetectable viral loads (<400copies/mL) at 96weeks of ART. Children with a baseline CD4 cell percent >15% were 3 times more likely to achieve viral load <400copies/mL than those with baseline CD4 cell percent <5% after adjusting for baseline age {aHR = 3.03 (1.10–8.32), p=0.03}; no difference was found among those with CD4 cell percent >5–14.9% and <5%.Conclusion
Treatment with generic adult FDC for HIV-infected Ugandan children led to sustained clinical, immunologic and virologic response during 96 weeks of ART. Early initiation of ART is key to achieving virological success. 相似文献92.
93.
Long‐term consequences of pain,anxiety and agitation for critically ill older patients after an intensive care unit stay
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94.
Bergantini L Cameli P d’Alessandro M Vagaggini C Refini RM Landi C Pieroni MG Spalletti M Sestini P Bargagli E 《Clinical and experimental medicine》2019,19(4):487-494
Clinical and Experimental Medicine - Background The pathogenetic and regulatory roles of natural killer (NK) and natural killer T-like cells in interstitial lung diseases (ILDs), fibrotic and... 相似文献
95.
L. Thurfjell Y. H. Lau J. L. R. Andersson B. F. Hutton 《European journal of nuclear medicine and molecular imaging》2000,27(7):847-856
Mutual information has been proposed as a criterion for image registration. The criterion is calculated from a two-dimensional
grey-scale histogram of the image pair being registered. In this paper we study how sparse sampling can be used to increase
speed performance using the registration algorithm of Maes et al. (IEEE Trans Med Imaging 1997; 16: 187–198) with a focus on registration of MRI-SPET brain images. In particular we investigate how sparse sampling
and parameters such as the number of bins used for the grey-scale histograms and smoothing of the data prior to registration
affect accuracy and robustness of the registration. The method was validated using both simulated and human data. Our results
show that sparse sampling introduced local maxima into the mutual information similarity function when the number of bins
used for the histograms was large. To speed up registration while retaining robustness, smoothing of the data prior to registration
was used and a coarse to fine subsampling protocol, where the number of bins in the histograms were dependent on the subsampling
factor, was employed. For the simulated data, the method was able to recover known transformations with an accuracy of about
1 mm. Using the human data, there were no significant differences in the recovered transformation parameters when the suggested
subsampling scheme was used compared with when no subsampling was used, but there was a more than tenfold increase in speed.
Our results show that, with the appropriate choice of parameters, the method can accurately register MRI-SPET brain images
even when very efficient sampling protocols are used.
Received 14 December 1999 and in revised form 15 March 2000 相似文献
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Alice L Scott Nima Abbassi-Ghadi Charles MG Archer Rajiv Swamy Sanjay Gupta 《Annals of the Royal College of Surgeons of England》2010,92(6):e5-e8
We discuss an unusual case of a large cystic mass arising in the left upper quadrant of a 48-year-old woman. Radiological investigations could not confirm the origin or the nature of the mass. A laparatomy revealed a large retroperitoneal cystic mass sandwiched between the left adrenal, spleen and the gastro-oesophageal junction. Histological analysis confirmed a mature teratoma of the retroperitoneum with neuroendocrine carcinoma arising within it. To our knowledge this is only the second reported case of its kind. 相似文献
100.
18F‐flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial
Rik Vandenberghe Koen Van Laere Adrian Ivanoiu Eric Salmon Christine Bastin Eric Triau Steen Hasselbalch Ian Law Allan Andersen Alex Korner Lennart Minthon Gaëtan Garraux Natalie Nelissen Guy Bormans Chris Buckley Rikard Owenius Lennart Thurfjell Gill Farrar David J. Brooks 《Annals of neurology》2010,68(3):319-329