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101.
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Yanaba K Asano Y Tada Y Sugaya M Kadono T Hamaguchi Y Sato S 《Clinical rheumatology》2012,31(5):835-839
CD147 is a glycosylated membrane protein that belongs to the immunoglobulin superfamily. This study aimed to determine serum
soluble CD147 (sCD147) levels and their clinical associations in patients with systemic sclerosis (SSc). Serum sCD147 levels
were examined by enzyme-linked immunosorbent assay in 61 SSc patients and 24 healthy individuals. Serum sCD147 levels were
significantly elevated in SSc patients compared with healthy individuals (P < 0.001). Among patients with SSc, there were no differences in serum sCD147 levels between limited cutaneous (n = 30) and diffuse cutaneous SSc (n = 31). Patients with SSc who had elevated sCD147 levels had renal crisis more often than those with normal sCD147 levels
(13% vs 0%; P < 0.05). Serum sCD147 levels were increased in patients with SSc and associated with the presence of renal crisis. These
results suggest that sCD147 may have a role in the development of renal crisis in SSc. Measurement of serum sCD147 may be
useful for risk stratification for renal crisis in SSc. 相似文献
103.
Ebara S Song SN Mizuta H Ito Y Hasegawa K Kamata T Matsumura-Nishikawa T Ogawa T Soneda J Yoshizaki K 《International journal of hematology》2012,95(2):198-203
Dysregulated overproduction of interleukin-6 (IL-6) from activated B cells in affected lymph nodes has been implicated in
the pathogenesis of multicentric Castleman’s disease (MCD), a rare lymphoproliferative disorder accompanied by systemic manifestations.
We here report the case of a 32-year-old female presenting with MCD associated with a dermoid cyst in the pelvic cavity. The
co-occurrence of MCD and dermoid cyst has not been reported before. Immunohistochemical analysis of the tissue sections showed
IL-6 production in CD68-positive macrophage cells, which had infiltrated the dermoid cyst. Removal of the cyst resulted in
partial improvement in systemic symptoms accompanied by a decrease in serum IL-6, while complete improvement was obtained
by treatment with an anti-IL-6 receptor antibody following resection of the dermoid cyst. To the best of our knowledge, this
is the first study to provide evidence of IL-6 production by CD68+ cells in a dermoid cyst involved in MCD. 相似文献
104.
Xu Z Kaga S Mochiduki A Tsubomizu J Adachi S Sakai T Inoue K Adachi AA 《Endocrine journal》2012,59(2):161-171
Kisspeptin/metastin has been implicated as a critical regulator in luteinizing hormone (LH) secretion and the reproductive system mediating the effect of estrogen on GnRH neurons. In the present study we examined the sex differences in the effects of estrogen on Kiss1/kisspeptin expression in the forebrain by using gonadectomized rats to assess the interaction of kisspeptin and GnRH neurons. Kiss1/kisspeptin cell bodies were abundant in the rostral periventricular area of the third ventricle (RV3P) and the arcuate nucleus (ARC). A few cell bodies were also observed in other portions of the forebrain, i.e. the bed nucleus of the stria terminalis (BST), the paraventricular hypothalamic nucleus (PaAP), the ventromedial hypothalamic nucleus (VMH), and the medial amygdaloid nucleus (MeA). Kisspeptin-immunoreactive fibers were found mainly in the median eminence (ME), the ARC, and the RV3P, but were scarce in the preoptic area (POA), where GnRH neurons are localized. We also found that estrogen triggers expression of the Kiss1 gene and peptide within all the regions except the ARC, and that the effects in the RV3P, BST, PaAP, and VMH are greater in estrogen treated ovariectomized female rat. It is noteworthy that kisspeptin and GnRH neurons were densely associated in the ME but were rarely in contact in the POA. Thus, our results suggest that kisspeptin-positive neurons, except for the ones in the ARC, are related not only to estrogen-positive feedback, but also sex dimorphism, and that kisspeptin regulates GnRH release in the ME rather than the POA. 相似文献
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Akamatsu T Shirai T Kato M Hashimoto D Yasui H Inui N Suda T Yokomura K Hayakawa H Ide K Toyoshima M Kuroishi S Yasuda K Suganuma H Yamada T Masuda M Chida K 《Allergology international》2012,61(2):323-329
BackgroundCombination therapy with an inhaled corticosteroid (ICS) and a long-acting β2-agonist (LABA) in a single inhaler is the mainstay of asthma management and salmeterol/fluticasone combination (SFC) and fixed-dose formoterol/budesonide combination (FBC) are currently available in Japan; however, there is nothing to choose between the two. The purpose of this study was to clarify the effect of switching from SFC to FBC in patients with asthma not adequately controlled under the former treatment regimen.MethodsThis was a prospective, multicenter, open-label, uncontrolled longitudinal study in 87 adult patients with an Asthma Control Questionnaire, 5-item version (ACQ5) score of greater than 0.75 under treatment with SFC 50/250 μg one inhalation twice daily (bid). SFC was switched to FBC 4.5/160 μg two inhalations bid. Study outcomes included ACQ5 score, peak expiratory flow (PEF), FEV1, and fractional exhaled nitric oxide (FeNO) at the end of treatment period.ResultsEighty-three patients completed the study. ACQ5 scores improved and exceeded the clinically meaningful difference after 12 weeks of treatment and well-controlled asthma (ACQ5 score ≤ 0.75) was attained in 37 (44.6%) patients. Minimum and maximum PEF and FEV1 values improved significantly, but not FeNO values, after switching from SFC to FBC.ConclusionsSwitching ICS/LABA combination therapy is a useful option in the management of asthma that is not optimally controlled. 相似文献
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109.
Mitsunaga Narushima M.D. Takuya Iida M.D. Takafumi Kadono M.D. Hisako Hara M.D. Yusuke Yamamoto M.D. Takeshi Todokoro M.D. Makoto Mihara M.D. Isao Koshima M.D. 《Microsurgery》2013,33(4):311-314
Free auricular flap transplantation is one of the treatments for nasal reconstruction. This report presents a case of nasal reconstruction where the infraorbital artery was used as a recipient vessel, and the infraorbital nerve as a recipient sensory nerve. A 75‐year‐old female underwent resection of malignant melanoma of the right nasal ala. A free ear concha flap was used for the reconstruction. The facial artery could not be found intraoperatively; instead, the infraorbital artery was identified and anastomosed with the posterior auricular artery. The great auricular nerve was coapted with the infraorbital nerve. The results of the sensory examination were the same as those of the unaffected side. This procedure not only achieves a good aesthetic outcome, but also restores sufficient sensory function. © 2013 Wiley Periodicals, Inc. Microsurgery, 2013. 相似文献
110.