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91.
An excess of psychiatric symptoms in post-hysterectomy women have been reported by some authors but denied by others. Thirty six women undergoing hysterectomy for non-malignant pathologies were compared with equal number of comparable patients who underwent other gynaecological operations. Patients were assessed pre- and post-operatively by semi-structured psychiatric interview, Sinha''s anxiety scale and Hamilton''s depression rating scale. Patients undergoing hysterectomy were significantly more anxious and depressed both pre- and post-operatively as compared to the control patients. Hysterectomy was not associated with significantly higher psychiatric morbidity.KEY WORDS: Hysterectomy, Depression 相似文献
92.
Albumin excretion in microalbuminuria range is one of the earliest manifestation of nephropathy, specially in diabetes mellitus. The modified dye binding method using bromo-phenol blue was studied in 27 healthy controls and 54 patients of diabetes mellitus, negative for albuminuria by albustix test. The analytical recovery (99.4 to 104.0%), within run coefficient of variation (0.8 to 0.36%) and day-to-day coefficient of variation (2.39 to 0.82%), for low and higher range were within acceptable limits. The values in controls ranged as follows: urinary albumin concentration (mg/L) 7.7 – 28.4 in 2-hour specimen and 10.3 – 29.2 in overnight specimen; albumin excretion rate (µg/min) 7.8 – 29.7 in 2-hour and 9.2 – 29.6 in overnight specimen; and albumin creatinine ratio (mg/g) 10.6 – 29.6 in 2-hour and 11.9 – 29.6 in overnight specimens.Correlation analysis of various albumin excretion parameters revealed excellent correlation between estimations from overnight and 2-hour samples for albumin-creatinine ratio (r = 1.00) and albumin excretion rate (r=0.96). Equally good correlation was observed between 2-hour albumin-creatinine ratio and albumin excretion rate (r=0.95). In 10 of 54 patients excretion rate was more than 200 µg/min and could have been detected by repeat albustix test. Of the 36 positive for microalbuminuria, 21 had one or more target organ involvement. There was no target organ involvement in 8 patients negative for microalbuminuria. Screening for microalbuminuria by this simple and economic method, using 2-hour albumin-excretion rate or albumin-creatinine ratio could be one of the earliest investigations in diabetic patients.KEY WORDS: Microalbuminuria, Spectrophotometeric method, Diabetes mellitus 相似文献
93.
Riffat Batool Ejaz Aziz Tariq Mahmood Benny KH Tan Vincent TK Chow 《Asian Pacific journal of tropical medicine》2018,(4)
Objective: To investigate the inhibitory effects against dengue virus serotype 2(DENV-2) by five different fractions(extracted by methanol, ethanol, benzene, chloroform and n-hexane) of Rumex dentatus, Commelina benghalensis, Ajuga bracteosa and Ziziphus mauritiana, as well as their constituents(gallic acid, emodin, and isovanillic acid). Methods: All the samples were tested for cytotoxicity on baby hamster kidney cells by MTT assay and for anti-DENV-2 activity by plaque reduction neutralization assay using two DENV-2 doses(45 and 90 plaqueforming units or PFU). Results: All the samples except isovanillic acid exhibited significant prophylactic effects against DENV-2 infectivity(without cytotoxicity) when administered to cells before infection, but were not effective when given 6 h post-infection. The methanol extract of Rumex dentatus demonstrated the highest antiviral efficacy by inhibiting DENV-2 replication, with IC_(50) of 0.154 μg/mL and 0.234 μg/mL, when added before infection with 45 and 90 PFU of virus, respectively. Gallic acid also exhibited significant antiviral effects by prophylactic treatment prior to virus adsorption on cells, with IC_(50) of 0.191 μg/mL and 0.522 μg/mL at 45 and 90 PFU of DENV-2 infection, respectively. Conclusions: The highly potent activities of the extracts and constituent compounds of these plants against DENV-2 infectivity highlight their potential as targets for further research to identify novel antiviral agents against dengue. 相似文献
94.
Pilgram TK; Vannier MW; Hildebolt CF; Marsh JL; McAlister WH; Shackelford GD; Offutt CJ; Knapp RH 《Radiology》1989,173(3):675-679
The authors used the diagnosis of craniosynostosis to compare subjective evaluation of image quality with objective diagnostic utility. They studied in detail the responses of one observer, who read plain radiographs, computed tomographic (CT) scans, and three-dimensional reconstructions of CT scans (obtained with three different methods) for 82 patients with this diagnosis. The observer rated image quality and certainty in diagnosis made from each image. Subjective and objective performances were found to be strongly linked. High-quality images served as the basis for more accurate diagnoses than low-quality images. The increase in diagnostic performance results primarily from increased specificity, a fact that suggests that specificity and the concomitant diagnosis of normalcy are the focus of attention when image quality is evaluated. 相似文献
95.
Background
The aim of this study was to evaluate the efficacy of heat cured ‘poly methyl methacrylate resin prosthesis and to assess the acceptability of the indigenously manufactured titanium mini bone plate and screws in patients treated for repair of cranial defects.Methods
17 patients with cranial defect were treated for reconstruction of the skull defect with two types of implants i.e. Acrylic resin plate prosthesis and titanium minibone plates, either in combination or singularly. In these cases, the skull defects resulted from trauma (88.23%) or due to ablative tumour surgery (11.96%). Acrylic implant was used in 12 cases (70.85%), titanium plates and screws in 2 cases (11.76%) and a combination of both of the above in 3 cases (17.64).Results
The primary reconstruction was carried out in 2 cases (11.96%) and secondary reconstruction was done in 15 cases (88.23%). Majority of the cases underwent secondary reconstruction because of the initial surgical emergency requiring quick debulking and closure. In 2 cases where primary reconstruction was done, the second surgery could be avoided with gratifying results.Conclusion
70.85% underwent reconstruction with polymethyl methacrylate resin prosthesis and in the rest either titanium plates were used singly or in combination. Only in one patient, there was rejection of the implant due to infection. In 94% cases the graft was well taken up with excellent results.Key Words: Cranial reconstruction, Mini bone plates, Cranial prosthesis 相似文献96.
97.
98.
154 patients requiring induction with unfavourable cervix at varying period of gestation were studied. Patients were distributed into two groups. 76 patients were induced with 0.5 mgm single dose intracervical application of Prostaglandin E2 gel and remaining 78 patients with Oxytocin and efficacy of the two methods of induction was compared. Labour was established within 24 hours in 71.4% of primigravidas and 91.7% of multigravidas in the prostaglandin treated group compared to 65.6% of primigravidas and 89.1% of multigravidas in the oxytocin group. The study found substantial improvement in cervical score 12 hours after application of intracervical prostaglandin E2 gel and decrease in Caesarean section rate with no major adverse effect to mother or neonate.KEY WORDS: Induction, Intracervical Prostaglandin E2 gel, Oxytocin 相似文献
99.
100.
Glucosinolates are sulphur compounds that occur as glycosides in brassica
vegetables. In response to tissue disruption they are degraded by
thioglucosidase, releasing a range of highly reactive breakdown products,
including the isothiocyanates, which we have previously shown to be
selectively cytotoxic to undifferentiated colorectal tumour cells (HT29).
In the present study we explored the effect of sinigrin on the intestinal
mucosa of rats previously treated with dimethylhydrazine (DMH). In the
first experiment, a semisynthetic feed containing sinigrin (400 microg/g
diet) was provided 6 h after the second of two injections of DMH. The level
of apoptosis was measured by morphological assessment of intact
microdissected crypts obtained at 18, 24, 38, 48 and 72 h after injection,
and compared with control groups given DMH only, or a sham-injection.
Higher numbers of apoptotic nuclei were present in colonic tissue from both
groups of DMH-treated rats compared with the controls, and the level was
significantly higher in DMH- treated rats fed sinigrin compared with those
given DMH only (P < 0.02). In a second experiment, rats were given
sinigrin (400 microg/g diet) 22 h after the second of two injections of
DMH; the level of apoptosis was measured after 48 h and the numbers of
aberrant crypt foci (ACF) were measured after 42 days. The level of
apoptosis was significantly higher in DMH-treated rats given sinigrin
compared with controls (P < 0.05), and the numbers of ACF were
significantly lower in sinigrin-treated rats (P < 0.001). There was no
statistically significant induction of apoptosis in animals fed sinigrin
alone. Sinigrin administered after DMH suppresses induction of ACF. This
may be due to increased apoptotic deletion of damaged stem cells in the
crypts of animals fed sinigrin.
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