全文获取类型
收费全文 | 1513164篇 |
免费 | 106754篇 |
国内免费 | 2542篇 |
专业分类
耳鼻咽喉 | 20852篇 |
儿科学 | 44780篇 |
妇产科学 | 38199篇 |
基础医学 | 224103篇 |
口腔科学 | 44872篇 |
临床医学 | 134119篇 |
内科学 | 291150篇 |
皮肤病学 | 32761篇 |
神经病学 | 112961篇 |
特种医学 | 57594篇 |
外国民族医学 | 156篇 |
外科学 | 236640篇 |
综合类 | 31123篇 |
现状与发展 | 2篇 |
一般理论 | 385篇 |
预防医学 | 106214篇 |
眼科学 | 35301篇 |
药学 | 116744篇 |
4篇 | |
中国医学 | 4203篇 |
肿瘤学 | 90297篇 |
出版年
2018年 | 15472篇 |
2017年 | 12053篇 |
2016年 | 13419篇 |
2015年 | 15091篇 |
2014年 | 20624篇 |
2013年 | 30668篇 |
2012年 | 41260篇 |
2011年 | 43363篇 |
2010年 | 25637篇 |
2009年 | 24362篇 |
2008年 | 41423篇 |
2007年 | 43830篇 |
2006年 | 44983篇 |
2005年 | 42645篇 |
2004年 | 41388篇 |
2003年 | 39541篇 |
2002年 | 38722篇 |
2001年 | 81880篇 |
2000年 | 84026篇 |
1999年 | 69808篇 |
1998年 | 17200篇 |
1997年 | 14974篇 |
1996年 | 15276篇 |
1995年 | 14390篇 |
1994年 | 13312篇 |
1993年 | 12230篇 |
1992年 | 53311篇 |
1991年 | 52009篇 |
1990年 | 50245篇 |
1989年 | 49270篇 |
1988年 | 44781篇 |
1987年 | 43645篇 |
1986年 | 41084篇 |
1985年 | 39015篇 |
1984年 | 28207篇 |
1983年 | 23974篇 |
1982年 | 12781篇 |
1981年 | 11229篇 |
1979年 | 25412篇 |
1978年 | 17456篇 |
1977年 | 14890篇 |
1976年 | 13597篇 |
1975年 | 14933篇 |
1974年 | 17866篇 |
1973年 | 17022篇 |
1972年 | 16095篇 |
1971年 | 15123篇 |
1970年 | 14473篇 |
1969年 | 13489篇 |
1968年 | 12349篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
62.
Reider N. Issa A. Hawranek T. 《世界核心医学期刊文摘》2006,2(3):48-49
芦荟自古就被用作化妆品和药物添加剂,近来更受喜爱。虽应用广泛,但过敏反应罕有报道。作者用芦荟叶的油性提取物、来自整个植株的芦荟粉及浓缩的芦荟凝胶,对相继就诊的702例患者做斑贴试验。设计专门的问卷调查芦荟的使用、使用原因、使用部位、不良反应、患者职业、个人爱好及是否为遗传性过敏体质。患者均未对任一制剂发生任何反应。需对芦荟所含的两种成分加以鉴别:即芦荟叶皮含有的具有促进肠蠕动、潜在抗菌及抗癌特性的蒽醌类物质。 相似文献
63.
64.
Zusammenfassung Viele gastrointestinale Tumoren werden im Rahmen multimodaler Therapiekonzepte behandelt. Für den Chirurgen ist die neoadjuvante, präoperative Behandlung von besonderem Interesse, da sie durch therapiebedingte Nebenwirkungen und Komplikationen zu einer Beeinflussung des postoperativen Verlaufs führen kann. Die neoadjuvante Radiochemotherapie ist fester Bestandteil der Therapie beim primären T4-Rektumkarzinom, beim Rektumkarzinomrezidiv und bei tief sitzenden primären Rektumkarzinomen. Durch Erhöhung der R0-Resektionsrate können die lokale Tumorkontrolle verbessert und die Überlebenszeit verlängert werden. Die postoperative Komplikationsrate ist dabei nicht wesentlich erhöht. In der Behandlung des primär resektablen Ösophaguskarzinoms deutet sich ein Vorteil der neoadjuvanten Radiochemotherapie im Vergleich zur alleinigen Chirurgie an. Beim lokal fortgeschrittenen Ösophaguskarzinom bietet die präoperative Radiochemotherapie häufig die einzige Chance zur Resektion, jedoch mit einer deutlich erhöhten postoperativen Morbidität und Mortalität. Die Wirksamkeit und Sicherheit einer neoadjuvanten Chemo- oder kombinierten Radiochemotherapie beim fortgeschrittenen Magenkarzinom wird derzeit im Rahmen von Studienprotokollen untersucht. 相似文献
65.
Published data devoted to making and characterization of the properties of polymeric wound dressings with proteolytic action
are reviewed. These data are indicative of individual dependence of the physicochemical properties, activity, and stability
of each particular enzyme on the type of polymer matrix and the method of immobilization. In order to obtain wound dressings,
which are active in physiological medium and retain their activity upon sterilization, it is necessary to optimize the composition
and characteristics of a polymer matrix and the enzyme included into its structure.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 8, pp. 24–28, August, 2006. 相似文献
66.
Ohne Zusammenfassung 相似文献
67.
BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry. 总被引:2,自引:0,他引:2
A Hamilton L Elrick S Myssina M Copland H J?rgensen J V Melo T Holyoake 《Leukemia》2006,20(6):1035-1039
In chronic myeloid leukaemia, CD34(+) stem/progenitor cells appear resistant to imatinib mesylate (IM) in vitro and in vivo. To investigate the underlying mechanism(s) of IM resistance, it is essential to quantify Bcr-Abl kinase status at the stem cell level. We developed a flow cytometry method to measure CrkL phosphorylation (P-CrkL) in samples with <10(4) cells. The method was first validated in wild-type (K562) and mutant (BAF3) BCR-ABL(+) as well as BCR-ABL(-) (HL60) cell lines. In response to increasing IM concentration, there was a linear reduction in P-CrkL, which was Bcr-Abl specific and correlated with known resistance. The results were comparable to those from Western blotting. The method also proved to be reproducible with small samples of normal and Ph(+) CD34(+) cells and was able to discriminate between Ph(-), sensitive and resistant Ph(+) cells. This assay should now enable investigators to unravel the mechanism(s) of IM resistance in stem cells. 相似文献
68.
F Pitta T Troosters V S Probst M A Spruit M Decramer R Gosselink 《The European respiratory journal》2006,27(5):1040-1055
Accurate assessment of the amount and intensity of physical activity in daily life is considered very important due to the close relationship between physical activity level, health, disability and mortality. For this reason, assessment of physical activity in daily life has gained interest in recent years, especially in sedentary populations, such as patients with chronic obstructive pulmonary disease (COPD). The present article aims to compare and discuss the two kinds of instruments more commonly used to quantify the amount of physical activity performed by COPD patients in daily life: subjective methods (questionnaires, diaries) and motion sensors (electronic or mechanical methods). Their characteristics are summarised and evidence of their validity, reliability and sensitivity is discussed, when available. Subjective methods have practical value mainly in providing the patients' view on their performance in activities of daily living and functional status. However, care must be taken when using subjective methods to accurately quantify the amount of daily physical activity performed. More accurate information is likely to be available with motion sensors rather than questionnaires. The selection of which motion sensor to use for quantification of physical activity in daily life should depend mainly on the purpose of its use. 相似文献
69.
R H Green C E Brightling S McKenna B Hargadon N Neale D Parker C Ruse I P Hall I D Pavord 《The European respiratory journal》2006,27(6):1144-1151
There is increasing evidence that the assessment of eosinophilic airway inflammation using induced sputum and measurement of airway hyperresponsiveness provides additional, clinically important information concerning asthma control. The aim of this study was to directly compare the effects of different treatments on these markers in patients with asthma and persistent symptoms, despite the use of low-dose inhaled corticosteroids. A double-blind four-way crossover study was performed, which compared a 1-month treatment with budesonide 400 mug b.i.d., additional formoterol, additional montelukast and placebo in 49 patients with uncontrolled asthma despite budesonide 100 mug b.i.d., with each treatment separated by a 4-week washout period. The change in sputum eosinophil count with formoterol (2.4 to 3.8% change, 0.6-fold reduction, 95% confidence interval (CI) 0.5-0.9) differed significantly from placebo (2.8 to 2.5% change, 1.1-fold reduction, 95% CI 0.7-1.6) and high-dose budesonide (2.7 to 1.6% change, 1.6-fold reduction, 95% CI 1.2-2.2). The effects of montelukast did not differ from placebo. The changes in methacholine airway responsiveness were small and did not differ between treatments. High-dose budesonide had the broadest range of beneficial effects on other outcomes, including symptom scores, morning peak expiratory flow and forced expiratory volume in one second. In conclusion, treatment given in addition to low-dose inhaled corticosteroids results in modest benefits. Formoterol and high-dose budesonide have contrasting effects on eosinophilic airway inflammation. 相似文献
70.
N B Pride 《The European respiratory journal》2006,27(1):240-1; author reply 241-2