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Marine Gaudry Pierre-Antoine Barral Arnaud Blanchard Sylvie Palazzolo Sonia Bolomey Virgile Omnes Mariangela De Masi Magali Carcopino-Tusoli Olivier Meyrignac Hervé Rousseau Alexis Jacquier Reda Hassen-Khodja Alessandra Bura-Rivière Jean-Michel Bartoli Stéphanie Gentile Philippe Piquet Laurence Bal 《European journal of vascular and endovascular surgery》2021,61(6):930-937
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Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress,autophagy, and miR‐34a/silent information regulator 1 pathway
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Elie Saliba Maria Cristina Albertini Sylvie Chalon Mariangela Longini Pierre Gressens Giuseppe Buonocore Walter Balduini 《Journal of pineal research》2016,61(3):370-380
Maternal infection/inflammation represents one of the most important factors involved in the etiology of brain injury in newborns. We investigated the modulating effect of prenatal melatonin on the neonatal brain inflammation process resulting from maternal intraperitoneal (i.p.) lipopolysaccharide (LPS) injections. LPS (300 μg/kg) was administered to pregnant rats at gestational days 19 and 20. Melatonin (5 mg/kg) was administered i.p. at the same time as LPS. Melatonin counteracted the LPS sensitization to a second ibotenate‐induced excitotoxic insult performed on postnatal day (PND) 4. As melatonin succeeded in reducing microglial activation in neonatal brain at PND1, pathways previously implicated in brain inflammation regulation, such as endoplasmic reticulum (ER) stress, autophagy and silent information regulator 1 (SIRT1), a melatonin target, were assessed at the same time‐point in our experimental groups. Results showed that maternal LPS administrations resulted in an increase in CHOP and Hsp70 protein expression and eIF2α phosphorylation, indicative of activation of the unfolded protein response consequent to ER stress, and a slighter decrease in the autophagy process, determined by reduced lipidated LC3 and increased p62 expression. LPS‐induced inflammation also reduced brain SIRT1 expression and affected the expression of miR‐34a, miR146a, and miR‐126. All these effects were blocked by melatonin. Cleaved‐caspase‐3 apoptosis pathway did not seem to be implicated in the noxious effect of LPS on the PND1 brain. We conclude that melatonin is effective in reducing maternal LPS‐induced neonatal inflammation and related brain injury. Its role as a prophylactic/therapeutic drug deserves to be investigated by clinical studies. 相似文献
96.
Emilie Ronin Charlotte Pouchy Maryam Khosravi Morgane Hilaire Sylvie Grgoire Armanda Casrouge Sahar Kassem David Sleurs Gaëlle H. Martin Nomie Chanson Yannis Lombardi Guilhem Lalle Harald Wajant Cdric Auffray Bruno Lucas Gilles Marodon Yenkel Grinberg-Bleyer Benoît L. Salomon 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(13)
97.
Sylvie LECLERCQ 《Industrial health》2014,52(5):393-398
Workplace design and upkeep, or human factors, are frequently advanced for explaining
so-called Occupational Slip, Trip and Fall Accidents (OSTFAs). Despite scientific
progress, these accidents, and more broadly Occupational Accidents with Movement
Disturbance (OAMDs), are also commonly considered to be “simple”. This paper aims to
stimulate changes in such perceptions by focusing on organisational factors that often
combine with other accident factors to cause movement disturbance and injury in work
situations. These factors frequently lead to arbitration between production and safety,
which involves implementation of controls by workers. These controls can lead to greater
worker exposure to OAMD risk. We propose a model that focuses on such controls to account
specifically for the need to confront production and safety logics within a company and to
enhance the potential for appropriate prevention action. These are then integrated into
the set of controls highlighted by work organisation model developed by the NIOSH. 相似文献
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Marie Robin Kavita Raj Sylvie Chevret Jordan Gauthier Hugues de Lavallade David Michonneau Donal McLornan Régis Peffault de Latour Victoria Potter Austin Kulasekararaj Flore Sicre de Fontbrune Antonio Pagliuca Ibrahim Yakoub‐Agha Gérard Socié Ghulam J. Mufti 《European journal of haematology》2018,101(4):466-474
100.
Edith Filaire Carmen Dupuis Géraud Galvaing Sylvie Aubreton Hélène Laurent Ruddy Richard Marc Filaire 《Lung cancer (Amsterdam, Netherlands)》2013
Oxidative stress appears to play an essential role as a secondary messenger in the normal regulation of a variety of physiological processes, such as apoptosis, survival, and proliferative signaling pathways. Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world. Lung cancer is the commonest fatal cancer whose risk is dependent on the number of cigarettes smoked per day as well as the number of years smoking, some components of cigarette smoke inducing oxidative stress by transmitting or generating oxidative stress. It can be subdivided into two broad categories, small cell lung cancer and non-small-cell lung cancer, the latter is the most common type. Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects. However, physical activity can have different influences on carcinogenesis, depending on energy supply, strength and frequency of exercise loads as well as the degree of exercise-mediated oxidative stress. Micronutrient supplementation seems to have a positive impact in lung surgery, particularly as an antioxidant, even if the role of micronutrients in lung cancer remains controversial. The purpose of this review is to examine lung cancer in relation to oxidative stress, physical activity, and nutrition. 相似文献