全文获取类型
收费全文 | 41193篇 |
免费 | 1934篇 |
国内免费 | 181篇 |
专业分类
耳鼻咽喉 | 692篇 |
儿科学 | 670篇 |
妇产科学 | 736篇 |
基础医学 | 5374篇 |
口腔科学 | 1223篇 |
临床医学 | 2908篇 |
内科学 | 9715篇 |
皮肤病学 | 551篇 |
神经病学 | 3404篇 |
特种医学 | 1392篇 |
外科学 | 7074篇 |
综合类 | 180篇 |
一般理论 | 2篇 |
预防医学 | 1496篇 |
眼科学 | 627篇 |
药学 | 3475篇 |
中国医学 | 86篇 |
肿瘤学 | 3703篇 |
出版年
2022年 | 412篇 |
2021年 | 713篇 |
2020年 | 355篇 |
2019年 | 496篇 |
2018年 | 593篇 |
2017年 | 462篇 |
2016年 | 564篇 |
2015年 | 602篇 |
2014年 | 794篇 |
2013年 | 1056篇 |
2012年 | 1697篇 |
2011年 | 1812篇 |
2010年 | 1040篇 |
2009年 | 896篇 |
2008年 | 1737篇 |
2007年 | 1898篇 |
2006年 | 1844篇 |
2005年 | 1822篇 |
2004年 | 1789篇 |
2003年 | 1806篇 |
2002年 | 1749篇 |
2001年 | 1620篇 |
2000年 | 1775篇 |
1999年 | 1502篇 |
1998年 | 482篇 |
1997年 | 391篇 |
1996年 | 363篇 |
1995年 | 303篇 |
1994年 | 286篇 |
1993年 | 261篇 |
1992年 | 1109篇 |
1991年 | 933篇 |
1990年 | 904篇 |
1989年 | 944篇 |
1988年 | 835篇 |
1987年 | 835篇 |
1986年 | 786篇 |
1985年 | 772篇 |
1984年 | 530篇 |
1983年 | 425篇 |
1982年 | 217篇 |
1979年 | 483篇 |
1978年 | 275篇 |
1977年 | 251篇 |
1975年 | 207篇 |
1974年 | 224篇 |
1972年 | 205篇 |
1971年 | 230篇 |
1969年 | 230篇 |
1968年 | 216篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
Takuro Yoshikawa Yasuyuki Suzuki Yasuhiro Fujino Keitaro Kakinoki Shiri Li Tadahiro Goto Tomohiro Tanaka Ippei Matsumoto Tetsuya Sakai Yasuki Tanioka Hiroshi Yokozaki Yoshikazu Kuroda 《American journal of transplantation》2005,5(9):2135-2142
Small bowel transplantation (SBT) is associated with a high incidence of infectious complications because of ischemia/reperfusion (I/R) mucosal injury concomitant with potent immunosuppression. In this study, we evaluated whether the cavitary two-layer method (cTLM) could reduce I/R injury and allow early mucosal restoration, particularly after prolonged preservation and transplantation. Canine heterotopic segmental SBT was performed immediately without preservation (group 1), after 24-h preservation in UW solution (group 2) or by the cTLM (group 3). The graft samples were taken 1 h after reperfusion and on days 1, 4 and 7. We assessed graft mucosa with detailed microscopic and electromicroscopic analyses. In Group 3, histological injury and cell apoptosis after transplantation were significantly alleviated and rapidly recovered to a similar level of group 1. The mucosal restoration was morphologically completed within 4 days. In contrast, in group 2, more pronounced mucosal injury and delayed recovery were noted. Crypt cell proliferation activity was well maintained in groups 1 and 3 throughout the experimental period. Our ultrastructural analysis suggested that mitochondrial integrity achieved by the cTLM was a basal mechanism under the prompt mucosal restoration. The cTLM could reduce I/R injury, facilitate mucosal regeneration and restore the nearly normal structure early after SBT. 相似文献
72.
73.
Yasuhiro Takikawa Yuki Yasumi Akihiro Sato Ryujin Endo Kazuyuki Suzuki Yasuki Mori Hidetoshi Akasaka Yasuhiro Miura Takashi Sawai Hiroaki Okamoto 《Hepatology research》2007,37(2):158-165
A 65-year-old Japanese man was hospitalized because of acute hepatitis and severe cholestasis due to hepatitis E virus (HEV) infection combined with a drug reaction to a cold preparation. He died of disseminated intravascular coagulation and severe intestinal bleeding due to systemic cytomegalovirus reactivation following the development of severe eruptions with marked eosinophilia due to drug hypersensitivity to taurine and ursodeoxycholate preparations. The close interaction between viral infection or reactivation and drug hypersensitivity was considered as a pathophysiology in this case, which emphasizes the need for further study of the immunological mechanism of the interaction. 相似文献
74.
D Craig Willcox Bradley J Willcox Sanae Shimajiri Sayuri Kurechi Makoto Suzuki 《The American journal of geriatric psychiatry》2007,15(3):252-256
OBJECTIVE: This study retrospectively explored the late-life functional status of Okinawan centenarians. METHODS: Activities of daily living were measured retrospectively at five time points (10, 5, 3, and 1 year prior and present) for 22 centenarians in relation to seven physical, two sensory, and two cognitive functions using the Inoue Index. RESULTS: In all, 82% of individuals were still functioning independently at a mean age of 92 years and almost two-thirds were still functioning independently at a mean age of 97 years. CONCLUSION: Preliminary analyses suggest high functional status in Okinawan centenarians throughout their 90 s. The genetic and environmental factors contributing to this successful aging phenomenon deserve further investigation. 相似文献
75.
76.
Positron emission tomography was performed on six patients with Rett syndrome to investigate cerebral blood flow and oxygen metabolism, and the results were compared with the concurrent clinical status of the patients. The cerebral metabolic rate of oxygen (CMRO2) was low in five patients, and oxygen extraction fraction was low in four patients; both had a tendency to decline with advancing age. Although the cause is unknown, it is suggested that impaired oxidative metabolism exists in Rett syndrome. An analysis of the distribution among brain regions showed that the ratios of values for the frontal cortex to those for the temporal cortex for both cerebral blood flow and CMRO2 were lower than those for the controls, which may indicate the loss of hyperfrontality in Rett syndrome. 相似文献
77.
78.
Reviewing the definition of "elderly" 总被引:1,自引:0,他引:1
Hajime Orimo Hideki Ito Takao Suzuki Atsushi Araki Takayuki Hosoi Motoji Sawabe 《Geriatrics & Gerontology International》2006,6(3):149-158
Conventionally, "elderly" has been defined as a chronological age of 65 years old or older, while those from 65 through 74 years old are referred to as "early elderly" and those over 75 years old as "late elderly." However, the evidence on which this definition is based is unknown. We have attempted to review the definition of elderly by analyzing data from long-term longitudinal epidemiological studies, and clinical and pathological studies that have been accumulated at the Tokyo Metropolitan Geriatric Hospital and the Tokyo Metropolitan Institute of Gerontology. Our recommendation might be a starting point in developing a strategy for a successful society by reviewing the definition of elderly based on comprehensive evidence in all aspects of social, cultural and medical sciences. 相似文献
79.
80.
Kenji Tsukada Shigeru Kobayashi Tatsuya Gotoh Naoki Asakage Masayuki Sekine Morio Sasaki Eiji Miyazaki Takahisa Suzuki Toshio Yamada Shu Hirai Shigetaka Yamazaki 《Digestive endoscopy》2006,18(1):55-58
A case of early gastric carcinoma accompanied by Dieulafoy ulcer is presented. The patient, a 26‐year‐old female, visited our emergency room with chief complaints of massive hematemesis and tarry stool. The initial endoscopic examination revealed a superficial depressed lesion with a faded color accompanied by a tiny ulcer with converging folds at the anterior wall of the middle gastric body. Although no active bleeding vessel was found at that time, the patient was admitted to our hospital for further check‐ups and treatment. On the 6th hospital day, she developed massive hematemesis resulting in shock. Urgent endoscopy, this time, disclosed an exposed bleeding vessel at the small ulcer floor previously mentioned, and endoscopic hemostasis was achieved. Since, however, a biopsy at initial examination from the surrounding depressed area proved carcinoma, a partial distal gastrectomy was subsequently carried out. Histological examination of the resected specimen confirmed the diagnosis of carcinoma limited to the mucosa and submucosa along with findings consistent with Dieulafoy ulcer. This is a rare case of combination of early cancer and Dieulafoy ulcer particularly in such a young patient. A review of the literature is also presented. 相似文献