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101.
Karin F Wikblad RN RNT BM BSc Lars B Wibell MD PhD Kent R Montin PhD Psychologist 《Journal of advanced nursing》1990,15(9):1083-1091
An instrument for measuring attitudes towards diabetes and self-care was constructed by a semantic differential technique. The instrument contained nine adjective pairs. Factor analysis classified these into four factors: self-esteem/autonomy, object evaluation, quality of life supporting factor and self-strength/vulnerability. The reliability coefficient of test-retest by 28 nurses/nurse tutors was 0.93. Fifty diabetic patients completed the attitude scale for testing the validity of the instrument. Male patients had a more positive attitude towards diabetes than females. Those who had had diabetes for less than 10 years were more positive than those with a longer duration of the disease. A higher degree of education, well-performed self-monitoring of blood glucose and achievement of good metabolic control were all associated with a more negative attitude towards diabetes. A group of nurses/nurse tutors who also completed the attitude scale had a more negative attitude towards diabetes than the investigated groups of patients. 相似文献
102.
SH Opdal TO Rognum Å Vege AK Stave BM Dupuy T Egeland 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(10):1039-1044
The purpose of the present study was to investigate substitutions in the D-loop of mitochondrial DNA (mtDNA) in sudden infant death syndrome (SIDS) and controls, since several observations indicate the involvement of mtDNA mutations in SIDS. These include elevated levels of vitreous humour hypoxanthine in SIDS victims, familial clustering without mendelian traits, and observations of increased sleepiness and a lower activity score in infants who later succumbed to SIDS. Eighty-two cases of SIDS and 133 controls were investigated and the D-loop sequences were recorded in the base-pair range 16 055-16 500 in the mtDNA sequence. The sequencing was carried out using the Applied Biosystems Sequenase dye terminator method and a ABD373A sequencer. The recorded D-loop sequences were compared with the Cambridge sequence and differences were recorded as substitutions. The SIDS cases had a tendency towards a higher substitution rate in the D-loop than the controls ( p = 0.088). This observation makes it interesting to search for deleterious mutations in other locations in the mtDNA. 相似文献
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104.
Methodological exemplar of integrating quantitative and qualitative evidence – supportive care for men with prostate cancer: what are the most important components? 下载免费PDF全文
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107.
Gastric function was assessed in Wistar rats which received propantheline bromide by daily injection for 20 weeks. The results were compared with those from two control groups, one of which was injected daily with saline for 20 weeks. Gastric acid secretion, as measured by test meal and after ligation of the pylorus, was similar in all three groups. Acid secretion, as measured by test meal with pentagastrin 100 µg/kg body weight, gastric emptying, and fundic mucosal volume, expressed in terms of body weight, were all significantly increased in rats given propantheline. Only those measurements of acid secretion obtained by test meal with pentagastrin showed a significant correlation with fundic mucosal volume. Hence, since this method provides the most accurate indication of secretory capacity, it is concluded that the prolonged parenteral administration of propantheline may lead to an increase in parietal cell mass and its correlate, maximal secretory capacity. The mechanism by which these changes are produced is obscure.The author is grateful to Mr. Howard Ireson for his expert technical assistance, and to Mr. Ralph Marshall, Department of Medical Illustration, Cardiff Royal Infirmary, for the photography employed.Propantheline bromide (Pro-Banthine) was generously supplied by G. D. Searle and Co., Ltd. 相似文献
108.
Osteomyelitis (bone infection) and neuro-osteoarthropathy (Charcot arthropathy) are limb-threatening complications of diabetic
neuropathy with very different therapies. Distinguishing between them may be difficult, but it is important. In Charcot arthropathy,
noninfectious soft tissue inflammation accompanies rapidly progressive destruction, first of joints, then of bone. This occurs
in a well-vascularized and severely neuropathic, but nonulcerated, foot. In osteomyelitis, chronic soft tissue ulceration
precedes infection of bone, which may be physically exposed. Magnetic resonance imaging and bone biopsy are the preferred
diagnostic tests, provided adequate technical and interpretive skills are available. 相似文献
109.
Dr. Ramanathan Visvanathan BM BCH FRCS FWACS FICS 《Digestive diseases and sciences》1992,37(10):1600-1605
H+ secretion was studied in guinea pig fundic mucosa incubated in (A) bicarbonate-Ringer's gassed with 95% O2-5% CO2, or (B) HEPES gassed with 100% O2 before and after luminal pH was lowered to 2.0 for periods up to 90 min. At pH 2.0 for 60 min, H+ secretion in group A tissues fell by 35±4% (P=0.02) from a control rate of 1.35±0.09 eq/cm2/hr and in group B tissues by 50±11% (P=0.01) from a control rate of 1.59±0.08 eq/cm2/hr. After 90 min at pH 2.0, H+ secretion in group A fell by 53±8% (P=0.02) from a control rate of 1.47±0.07 eq/cm2/hr and in group B fell by 44±6% (P=0.01) from a control rate of 1.38±0.07 eq/cm2/hr. Histamine 1×10–4 M stimulation following exposure to pH 2.0 for 90 min increased secretion in group A tissues from 0.80 ±0.14 to 1.06±0.13 eq/cm2/hr (P<0.05), compared with an increase in nonacidified controls from 1.15±0.22 to 1.80±0.20 eq/cm2/hr (P<0.05) and in group B tissues from 1.27±0.10 to 1.56±0.19 eq/cm2/hr (P<0.05) compared with nonacidified controls from 1.43±0.22 to 2.23±0.41 eq/cm2/hr (P<0.05). Secretory function and electrical characteristics were adversely affected by luminal acidification to pH 2.0 and suggested a breach in the mucosal barrier with damage to parietal cells.This study was funded by the National Institute of Health Grant No. AM 15681. 相似文献
110.
Remnant Lipoprotein Cholesterol and Mortality After Acute Myocardial Infarction: Further Evidence for a Hypercholesterolemia Paradox From the TRIUMPH Registry 下载免费PDF全文
Seth S. Martin MD MHS Kamil F. Faridi MD Parag H. Joshi MD MHS Michael J. Blaha MD MPH Krishnaji R. Kulkarni PhD Arif A. Khokhar BM BCh MA Thomas M. Maddox MD Edward P. Havranek MD Peter P. Toth MD PhD Fengming Tang MS John A. Spertus MD MPH Steven R. Jones MD 《Clinical cardiology》2015,38(11):660-667