全文获取类型
收费全文 | 2368篇 |
免费 | 178篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 140篇 |
妇产科学 | 30篇 |
基础医学 | 280篇 |
口腔科学 | 31篇 |
临床医学 | 166篇 |
内科学 | 493篇 |
皮肤病学 | 27篇 |
神经病学 | 197篇 |
特种医学 | 111篇 |
外科学 | 401篇 |
综合类 | 19篇 |
预防医学 | 100篇 |
眼科学 | 96篇 |
药学 | 226篇 |
中国医学 | 3篇 |
肿瘤学 | 214篇 |
出版年
2023年 | 17篇 |
2022年 | 66篇 |
2021年 | 100篇 |
2020年 | 48篇 |
2019年 | 91篇 |
2018年 | 93篇 |
2017年 | 63篇 |
2016年 | 50篇 |
2015年 | 79篇 |
2014年 | 99篇 |
2013年 | 156篇 |
2012年 | 190篇 |
2011年 | 158篇 |
2010年 | 106篇 |
2009年 | 72篇 |
2008年 | 89篇 |
2007年 | 103篇 |
2006年 | 103篇 |
2005年 | 69篇 |
2004年 | 69篇 |
2003年 | 59篇 |
2002年 | 69篇 |
2001年 | 57篇 |
2000年 | 54篇 |
1999年 | 38篇 |
1998年 | 27篇 |
1997年 | 12篇 |
1996年 | 16篇 |
1995年 | 9篇 |
1993年 | 7篇 |
1992年 | 27篇 |
1991年 | 37篇 |
1990年 | 33篇 |
1989年 | 28篇 |
1988年 | 24篇 |
1987年 | 19篇 |
1986年 | 19篇 |
1985年 | 21篇 |
1984年 | 14篇 |
1983年 | 11篇 |
1982年 | 10篇 |
1981年 | 10篇 |
1980年 | 9篇 |
1979年 | 10篇 |
1977年 | 9篇 |
1975年 | 10篇 |
1974年 | 9篇 |
1973年 | 11篇 |
1972年 | 9篇 |
1971年 | 7篇 |
排序方式: 共有2555条查询结果,搜索用时 93 毫秒
31.
Chikwendu Ibebunjo Coimbatore B. Srikant François Donati 《Journal canadien d'anesthésie》1996,43(5):475-484
Purpose
Although differences in fibre composition, fibre size or acetylcholine receptor (AChR) density between muscles have often been proposed to explain the unequal sensitivities of muscles to muscle relaxant drugs, it is not clear whether or how these parameters differ among muscles or are related to one another. In this study, several muscles were examined to determine the composition and cross-sectional area (CSA) of types I and II fibres, the surface area of their motor endplates (ESA), and their AChR density.Methods
Biopsies from the thyroarytenoideus, cricoarytenoideus dorsalis, masseter, diaphragm, transversus abdominis, rectus abdominis, gastrocnemius and soleus muscles of goats were processed by muscle histochemistry and morphometry and the ESA:CSA ratio was computed. The number and density of AChRs per endplate were estimated by125I-α-bungarotoxin binding studies.Results
The mean type 1 fibre composition (range: 0–100%), fibre diameter (28–50 μm) and the ESA:CSA ratio (0.27–1.01) differed among muscles (P = 0.0001), but there were no significant differences (P > 0.05) in the mean endplate size (577–725 μm2), AChR number (6.6?14.5 × 106) or AChR density (8,900–22,300 μm?2) probably because of marked individual variations. Fibre size increased and the ESA:CSA ratio decreased in the order laryngeal, diaphragm, jaw, limb and abdominal muscles.Conclusion
It is concluded that between muscles fibre size varies more than endplate size or AChR number. 相似文献32.
Sung‐Whi Rhee Radhakrishnan P. Iyer John E. Coughlin Seetharamaiyer Padmanabhan Jeremiah P. Malerich Mary J. Tanga 《Journal of labelled compounds & radiopharmaceuticals》2012,55(6):197-200
The 35S‐labeled, dinucleoside phosphorothioate 1, an orally available agent against hepatitis B virus, was prepared in eight steps with high specific activity and radiochemical purity. Radiolabeled 3H‐benzodithiole‐3‐one‐1,1‐dioxide was synthesized in four steps from 35S8 and was used as the sulfurizing reagent. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
33.
Vidya Iyer 《The European journal of contraception & reproductive health care》2013,18(4):339-350
Nonoxynol-9 (N-9) is a typical surfactant. For more than 30 years that very property of N-9 has been successfully exploited for its spermicidal action. It is available as an over-the-counter, locally acting vaginal spermicide. The suitability of N-9 as a spermicide is elaborated in this article. The reasons why N-9 may fail as a contraceptive are discussed. In spite of many drawbacks, which are mentioned in the article, N-9 is still often resorted to as a locally acting contraceptive. The review ends with suggestions to alter the molecular structure of N-9 and to adjust the dosages. 相似文献
34.
Andrew Holden Andrew A. Hill Brendan Buckley Brigid Connor David Semple Stephen Merrilees Emma Marsh Aws Alfahad Ram Iyer 《Journal of vascular and interventional radiology : JVIR》2019,30(1):61-68
Purpose
A prospective, single-center, single-arm feasibility study evaluated procedural and short-term performance of the Advance Enforcer 35 focal-force percutaneous transluminal angioplasty (PTA) balloon catheter in treating stenoses of mature native arteriovenous (AV) hemodialysis access circuits.Materials and Methods
Twenty-eight patients undergoing treatment for stenosis of a mature native AV hemodialysis access circuit were enrolled at a single institution. Angiographic assessments of the study lesion were required at baseline and after the procedure. Adjunctive procedures for significant residual stenosis were permitted, and patients had clinical and imaging follow-up for as long as 6 months.Results
Treatment with the study balloon was effective in reducing the average percent diameter stenosis of the treated lesion from 66.3% (range, 43.8%–93.3%) before the procedure to 23.7% (range, ?6.7% to 51.4%) after the procedure. The average inflation pressure required was 12.3 atm. Only 1 patient required an adjunctive procedure, and all patients could resume normal dialysis following the study procedure. At 3 months, 62.0% of study lesions remained patent, and the 6-month patency rate was 25.1%. Two adverse events associated with the study procedure were reported: access-site hematoma and forearm pain (3.6% each).Conclusions
The results demonstrate safety of the study balloon in treating AV access stenosis. Nominal-diameter angioplasty was achieved at relatively low pressure in most study patients without the use of adjunctive procedures, and resumption of normal dialysis was achieved for all patients. 相似文献35.
Abdominal pain is one of the common symptoms reported by children in urgent care clinics. While most children tend to have self-limiting conditions, the treating pediatrician should watch out for underlying serious causes like intestinal obstruction and perforation peritonitis, which require immediate referral to an emergency department (ED). Abdominal pain may be secondary to surgical or non-surgical causes, and will differ as per the age of the child. The common etiologies for abdominal pain presenting to an urgent care clinic are acute gastro-enteritis, constipation and functional abdominal pain; however, a variety of extra-abdominal conditions may also present as abdominal pain. Meticulous history taking and physical examination are the best tools for diagnosis, while investigations have a limited role in treating benign etiologies. 相似文献
36.
This study demonstrates a rapid prototyping approach for fabricating and integrating porous hollow fibers (HFs) into microfluidic device. Integration of HF can enhance mass transfer and recapitulate tubular shapes for tissue-engineered environments. We demonstrate the integration of single or multiple HFs, which can give the users the flexibility to control the total surface area for tissue development. We also present three microfluidic designs to enable different co-culture conditions such as the ability to co-culture multiple cell types simultaneously on a flat and tubular surface, or inside the lumen of multiple HFs. Additionally, we introduce a pressurized cell seeding process that can allow the cells to uniformly adhere on the inner surface of HFs without losing their viabilities. Co-cultures of lung epithelial cells and microvascular endothelial cells were demonstrated on the different platforms for at least five days. Overall, these platforms provide new opportunities for co-culturing of multiple cell types in a single device to reconstruct native tissue micro-environment for biomedical and tissue engineering research. 相似文献
37.
Shilesh Iyer 《Journal of cosmetic and laser therapy》2013,15(1):49-52
This is a case report of an 89‐year‐old woman with a lentigo maligna treated with alexandrite and ruby lasers. The lentigo maligna never completely resolved despite multiple treatments. Marked cosmetic improvement, however, was obtained. No adverse sequelae have occurred. 相似文献
38.
39.
Hong Chee Chew Arjun Iyer Mark Connellan Sarah Scheuer Jeanette Villanueva Ling Gao Mark Hicks Michelle Harkness Claudio Soto Andrew Dinale Priya Nair Alasdair Watson Emily Granger Paul Jansz Kavitha Muthiah Andrew Jabbour Eugene Kotlyar Anne Keogh Kumud Dhital 《Journal of the American College of Cardiology》2019,73(12):1447-1459
Background
Transplantation of hearts retrieved from donation after circulatory death (DCD) donors is an evolving clinical practice.Objectives
The purpose of this study is to provide an update on the authors’ Australian clinical program and discuss lessons learned since performing the world’s first series of distantly procured DCD heart transplants.Methods
The authors report their experience of 23 DCD heart transplants from 45 DCD donor referrals since 2014. Donor details were collected using electronic donor records (Donate Life, Australia) and all recipient details were collected from clinical notes and electronic databases at St. Vincent’s Hospital.Results
Hearts were retrieved from 33 of 45 DCD donors. A total of 12 donors did not progress to circulatory arrest within the pre-specified timeframe. Eight hearts failed to meet viability criteria during normothermic machine perfusion, and 2 hearts were declined due to machine malfunction. A total of 23 hearts were transplanted between July 2014 and April 2018. All recipients had successful implantation, with mechanical circulatory support utilized in 9 cases. One case requiring extracorporeal membrane oxygenation subsequently died on the sixth post-operative day, representing a mortality of 4.4% over 4 years with a total follow-up period of 15,500 days for the entire cohort. All surviving recipients had normal cardiac function on echocardiogram and no evidence of acute rejection on discharge. All surviving patients remain in New York Heart Association functional class I with normal biventricular function.Conclusions
DCD heart transplant outcomes are excellent. Despite a higher requirement for mechanical circulatory support for delayed graft function, primarily in recipients with ventricular assist device support, overall survival and rejection episodes are comparable to outcomes from contemporary brain-dead donors. 相似文献40.
Neil B. Marya Patrick D. Powers Larissa Fujii-Lau Barham K. Abu Dayyeh Ferga C. Gleeson Shigao Chen Zaiyang Long David M. Hough Vinay Chandrasekhara Prasad G. Iyer Elizabeth Rajan William Sanchez Tarek Sawas Andrew C. Storm Kenneth K. Wang Michael J. Levy 《Gastrointestinal endoscopy》2021,93(5):1121-1130.e1