全文获取类型
收费全文 | 4870篇 |
免费 | 257篇 |
国内免费 | 176篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 92篇 |
妇产科学 | 101篇 |
基础医学 | 700篇 |
口腔科学 | 118篇 |
临床医学 | 431篇 |
内科学 | 974篇 |
皮肤病学 | 103篇 |
神经病学 | 311篇 |
特种医学 | 536篇 |
外科学 | 570篇 |
综合类 | 41篇 |
预防医学 | 196篇 |
眼科学 | 95篇 |
药学 | 546篇 |
1篇 | |
中国医学 | 45篇 |
肿瘤学 | 412篇 |
出版年
2023年 | 24篇 |
2022年 | 39篇 |
2021年 | 120篇 |
2020年 | 59篇 |
2019年 | 79篇 |
2018年 | 109篇 |
2017年 | 79篇 |
2016年 | 142篇 |
2015年 | 186篇 |
2014年 | 207篇 |
2013年 | 266篇 |
2012年 | 325篇 |
2011年 | 331篇 |
2010年 | 228篇 |
2009年 | 209篇 |
2008年 | 265篇 |
2007年 | 355篇 |
2006年 | 219篇 |
2005年 | 212篇 |
2004年 | 164篇 |
2003年 | 146篇 |
2002年 | 131篇 |
2001年 | 137篇 |
2000年 | 129篇 |
1999年 | 86篇 |
1998年 | 102篇 |
1997年 | 101篇 |
1996年 | 89篇 |
1995年 | 68篇 |
1994年 | 50篇 |
1993年 | 62篇 |
1992年 | 30篇 |
1991年 | 43篇 |
1990年 | 27篇 |
1989年 | 69篇 |
1988年 | 41篇 |
1987年 | 45篇 |
1986年 | 39篇 |
1985年 | 36篇 |
1984年 | 25篇 |
1983年 | 17篇 |
1982年 | 36篇 |
1981年 | 21篇 |
1980年 | 16篇 |
1979年 | 11篇 |
1978年 | 10篇 |
1977年 | 23篇 |
1976年 | 32篇 |
1975年 | 18篇 |
1967年 | 7篇 |
排序方式: 共有5303条查询结果,搜索用时 303 毫秒
101.
Zimmermann A Pöllinger B Rieber J König A Erhard I Krötz F Sohn HY Kantlehner R Haimerl W Dühmke E Leibig M Theisen K Klauss V Schiele TM 《Zeitschrift für Kardiologie》2005,94(4):239-246
Summary
In-stent restenosis (ISR) represents the major limitation of stent implantation. Treatment, although of relative technical ease, is unsatisfactory due to a high incidence of recurrent restenosis. Vascular brachytherapy (VBT) has emerged as a powerful adjunct therapeutic modality to treat ISR. Inhibition of neointima formation has been regarded as the relevant mechanism of action. Yet, positive remodelling has been suspected as another contributing factor. Since only very few precise analyses of the extent, distribution and time course of the respective mechanims exist, the goal of the present study was to describe the changes of the vessel geometry at the target lesion and at the reference site following angioplasty and VBT of ISR in 42 patients by means of quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS) before and after the index procedure and at the 3 and 6 month follow-up.By QCA the acute lumen gain measured 2.2±0.8 mm, the late lumen loss at 3 months was 0.1±0.5 mm and at 6 months 0.4±0.7 mm. By IVUS luminal cross-sectional area increased from 1.5±1.2 mm2 to 7.9±1.9 mm2 (p<0.001). The intima hyperplasia cross-sectional area at 3 months was only 0.2±1.0 mm2 (p=0.191), but increased to 0.7±0.6 mm2 (p<0.001) at 6 months resulting in a lumen cross-sectional area of 7.1±1.7 mm2. Stent dimensions did not show any significant changes over time. The external elastic membrane cross-sectional area at 3 months increased by 1.3±1.9 mm2 (p<0.001), and showed a further increase by 0.7±2.9 mm2 at 6 months. Positive remodelling could be demonstrated also at the reference segment.In conclusion the absolute amount of intima hyperplasia during a 6-month follow-up period after VBT of ISR is low and most pronounced between the third and sixth month. Besides this, predominantly within the first 3 months of follow-up, significant positive remodelling could be demonstrated at the target lesion and at the reference site. Both observed effects may contribute to the preservation of the vessel lumen.Diese Publikation enthält die Ergebnisse der Promotionsarbeit von Frau Andrea Zimmermann 相似文献
102.
Absence of postprandial surge in coronary blood flow distal to significant stenosis: a possible mechanism of postprandial angina 总被引:2,自引:0,他引:2
Chung WY Sohn DW Kim YJ Oh S Chai IH Park YB Choi YS 《Journal of the American College of Cardiology》2002,40(11):1976-1983
OBJECTIVES: This study was designed to investigate a possible mechanism of postprandial angina. BACKGROUND: Postprandial angina has been recognized for more than two centuries; however, its mechanism is still controversial. The most widely accepted mechanism involves increased myocardial oxygen demand after food intake. Recently, the redistribution in coronary blood flow (CBF) was suggested as a possible mechanism. METHODS: Twenty young, healthy volunteer controls and 20 patients with significant stenosis in the left anterior descending (LAD) or left main coronary artery were enrolled in the study. Coronary blood flow was evaluated in the distal LAD by using transthoracic Doppler echocardiography before and 15, 30, 45, and 60 min after food intake. In the CBF curve, the time velocity integral of diastolic flow (Dtvi) and the product of Dtvi and heart rate (HR) were measured. In six patients, these measurements were repeated after successful coronary intervention. RESULTS: In the healthy volunteer controls, Dtvi and Dtvi x HR increased after food intake with a peak value at 15 min, which indicates the presence of postprandial surge in the CBF. Fasting values and peak values at 15 min were significantly different (Dtvi: 15.1 +/- 4.9 cm/s vs. 18.9 +/- 5.9 cm/s, p = 0.04, Dtvi x HR: 862.2 +/- 261.5 cm/min vs. 1,174.2 +/- 307.5, p = 0.002). In contrast with the controls, despite postprandial increase in double product (HR x blood pressure), Dtvi and Dtvi x HR in the patient group decreased after food intake, with a nadir value at 45 min. Fasting values and nadir values at 45 min were significantly different (Dtvi: 24.0 +/- 19.6 cm/s vs. 19.3 +/- 17.1 cm/s, p < 0.001, Dtvi x HR: 1,449.6 +/- 1,044.0 cm/min vs. 1,273.4 +/- 1,000.9 cm/min, p = 0.002). In six patients, the CBF pattern resumed the normal pattern of postprandial surge in the CBF after successful coronary intervention. CONCLUSIONS: Results of our study suggest that "steal phenomenon" may play a role in the mechanism of postprandial angina. 相似文献
103.
Mucinous Cystadenoma: Pitfalls of Differential Diagnosis 总被引:1,自引:0,他引:1
Jonathan R. Sachs M.D. Julius J. Deren M.D. Min Sohn M.D. Moreye Nusbaum M.D. 《The American journal of gastroenterology》1989,84(7):811-816
Cystic neoplasms of the pancreas often are difficult to differentiate from pseudocysts. It has been proposed that a history of clinical pancreatitis, elevated serum pancreatic enzymes, elevated cyst fluid amylase, and a communication with the pancreatic duct suggest the diagnosis of a pseudocyst. We report the case of a young woman who presented with a cystic mass in the pancreas and was thought to have a pseudocyst because of the above; at surgery, a mucinous cystadenoma was documented. The pitfalls of differentiating neoplastic cysts of the pancreas from pseudocysts are discussed. 相似文献
104.
Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men 总被引:14,自引:0,他引:14
Park SH Kim BI Yun JW Kim JW Park DI Cho YK Sung IK Park CY Sohn CI Jeon WK Kim H Rhee EJ Lee WY Kim SW 《Journal of gastroenterology and hepatology》2004,19(6):694-698
BACKGROUND AND AIM: Although insulin resistance is often considered the link between obesity and non-alcoholic fatty liver disease (NAFLD), the role of insulin resistance, independent of obesity, as a NAFLD risk factor in non-obese men has been less well established. Systemic inflammation may be accompanied by insulin resistance in healthy subjects. The goal of the present study was to examine if insulin resistance and systemic inflammatory markers are independent predictors of NAFLD in non-obese men. METHODS: The authors conducted a cross-sectional survey of 120 patients with NAFLD and 240 controls matched by age and body mass index. Controls had no evidence of alcohol abuse, hepatitis B or C, obesity, or previous history of diabetes, fasting hyperglycemia or hypertension. Diagnosis of NAFLD was based on an elevated alanine aminotransferase level and sonographic evidence of a fatty liver. Insulin resistance was determined using a homeostasis model assessment (HOMA-IR). RESULTS: The age-adjusted risk of developing NAFLD was strongly associated with the elevated levels in measurements of uric acid, fasting blood sugar, triglycerides, apolipoprotein B, C-reactive protein (CRP) and HOMA-IR, and decreased levels of high density lipoprotein cholesterol and apolipoprotein A-I. Multivariate analysis based on univariate analysis indicated that an increase in CRP (odds ratio [OR] = 1.37; 95% confidence interval [CI]: 1.06-1.77) per 1 SD (1.48 mg/L) and HOMA-IR (OR = 2.28; 95% CI: 1.67-3.11) per 1 SD (0.63) were independent risk factors for NAFLD. CONCLUSION: Insulin resistance and systemic inflammatory response are of key importance for inducing NAFLD, particularly in apparently healthy non-obese men. 相似文献
105.
Hang Lak Lee Joo Hyun Sohn Jin Bae Kim Dong Soo Han Yong Chul Jeon Joon Soo Hahm Dong Hoo Lee Chun Suk Kee Yong Wook Park 《Taehan Sohwagi Hakhoe chi》2005,46(3):233-236
Leiomyosarcoma is an uncommon tumor which arises from various sites including uterus, stomach, retroperitoneum, superficial soft tissues, bladder, kidney, and lung. Primary hepatic leiomyosarcoma is a very rare tumor and fewer than 70 cases of primary hepatic leiomyosarcoma have been reported since the first publication in Japan. And there was only one case report of cutaneous metastasis from hepatic leiomyosarcoma. We recently experienced a case of primary hepatic leiomyosarcoma presenting as subcutaneous palpable mass. Herein we report this case with a review of literatures. 相似文献
106.
Kim Myeong Gyu Lee Na Eun Sohn Hyun Soon 《International journal of clinical pharmacy》2020,42(2):677-684
International Journal of Clinical Pharmacy - Background Assessing and satisfying patient expectation are essential in successful patient-centered communication. Recognizing the gap between patient... 相似文献
107.
108.
Jeonghyun Kang Hyunki Kim Hyuk Hur Byung Soh Min Seung Hyuk Baik Kang Young Lee Seung Kook Sohn Nam Kyu Kim 《Yonsei medical journal》2013,54(1):131-138
Purpose
Circumferential resection margin (CRM) involvement is a well-known predictor for poor prognosis in rectal cancer. However, the significance is controversial in some studies. Accordingly, this study attempted to examine the prognostic impact of CRM involvement in stage III rectal cancer.Materials and Methods
Between January 1990 and December 2007, a total of 449 patients who underwent curative resection followed by complete adjuvant chemoradiotherapy for stage III rectal cancer located within 12 cm from the anal verge were selected. Patients were divided into a CRM-positive group (n=79, 17.6%) and a CRM-negative group (n=370, 82.4%).Results
With a median follow-up of 56.6 months, recurrent disease was seen in 53.2 and 43.5% of the CRM-positive and CRM-negative group, respectively. CRM involvement was an independent prognostic factor for 5-year systemic recurrence-free survival (HR: 1.5, CI: 1.0-2.2, p=0.017). However, no significant difference was observed for local recurrence rate between the two groups (13.0 and 13.5%, respectively, p=0.677).Conclusion
In this study, local recurrence rate did not differ according to CRM involvement status in stage III rectal cancer patients, although CRM involvement was shown to be an independent poor prognostic factor. Accordingly, validation of the results of this study by further large prospective randomized trials is warranted. 相似文献109.
110.