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521.
GIANLUCA RIGATELLI M.D. Ph.D. FABIO DELL'AVVOCATA M.D. PAOLO CARDAIOLI M.D. MASSIMO GIORDAN M.D. HO THUONG DUNG M.D. NGUYEN THUONG NGHIA M.D. Ph.D. RAMESH DAGGUBATI M.D. ARAVINDA NANJIUNDAPPA M.D. 《Journal of interventional cardiology》2012,25(6):628-634
Background: The need for sizing the secundum atrial septal defect (ASD) with the balloon sizing technique is still debated at least in adult patients. We sought to prospectively evaluate the effectiveness of intracardiac echocardiography (ICE)‐aided sizing technique for transcatheter closure of secundum ASD, without using a balloon sizing. Methods: In a prospective 5‐year registry, we enrolled 81 patients (mean age 48 ± 13.7 years, 54 females) who had been referred to three different centers for catheter‐based closure of secundum ASD. Eligible patients underwent ICE study and closure attempt. In a preliminary group of 21 patients, sizing balloon was performed under ICE guidance to assess the value of rim thickness necessary for device anchorage. In the remaining 60 patients, the retrieved value of the rim thickness was measured on ICE and used as key points to measure the defect and select the device. Results: In the preliminary group of patients, the value of thickness at point of initial deflection by the balloon was 1.23 ± 0.1 mm. ASD diameter in the study group was measured at the point of rim with at least 1.2 mm and the mean ASD diameter was 26.2 ± 10.1 mm. Rates of procedural success, predischarge occlusion, and major complications rate were 100%, 93.3%, and 0%, respectively. On mean follow‐up of 5.4 ± 1.8 years, the occlusion rate was 98.7% with no long‐term complications. Conclusions: Our novel ICE‐sizing technique appears to be safe and effective in adult patients, thus eventually minimizing overestimation, costs, and potential complications of balloon sizing. (J Interven Cardiol 2012;25:628–634) 相似文献
522.
特发性单侧透明肺的影像诊断 总被引:2,自引:0,他引:2
目的分析特发性单侧透明肺的影像诊断。方法本组共29例特发性单侧透明肺。29例均拍胸部正侧位片,其中19例行电视透视,14例行胸部CT扫描,2例做支气管造影,1例行体层摄影,1例行肺动脉、主动脉造影。结果29例患肺透亮度增大,其中左全肺23例,左下叶5例,左全肺并右肺中下叶1例。左肺门及肺血管性纹理细小。21例左侧胸廓轻度塌陷,21例纵隔气管左偏,19例电视透视见纵隔摆动,14例CT扫描见左肺动脉细小,其中主干细小9例,左肺下叶动脉细小5例。12例见右下肺动脉干增粗,5例动脉段延长,7例肺动脉段突出,4例心脏增大,19例支气管扩张。结论影像学检查是特发性单侧透明肺的关键确诊手段。 相似文献
523.
次黄嘌呤-内源性单胺氧化酶(MAO)抑制剂样活性的研究 总被引:2,自引:0,他引:2
体外实验证明,嘌呤类化合物对B-型MAO活性有不同程度的抑制作用,其抑制强度为:次黄嘌呤>鸟便嘌呤>腺嘌呤>嘌呤>黄嘌呤>尿酸。老龄小鼠(18月龄)的血、脑及肝组织MAO活性较年青小鼠(1月龄)显著升高,而上述组织中嘌呤类化合物的含量却随年龄增加而降低。老龄小鼠肝线粒体外膜MAO提取物中次黄嘌呤含量明显低于年青小鼠,但两组MAO中腺嘌呤含量却无明显差异。离体温孵实验证明[3H]次黄嘌呤与老龄小鼠脑和肝MAO结合量明显高于年青小鼠。体内结合实验结果亦表明[3H]次黄嘌呤与老龄小鼠肝MAO结合量高于年青小鼠外,并证明[3H]次黄嘌呤的结合部位是在MAO酶蛋白上,而非在辅基上。此外,多次灌服次黄嘌呤200mg/kg可明显抑制老龄小鼠脑MAO-B活性,并使单胺类物质(5-HT、DA)含量明显增加。 相似文献
524.
目的 鲁府禁方内之八白散为我国有名的美容方剂,有着使皮肤白晰的作用。本研究旨在观察方中个别中药水提物之活性,及探讨使用80%乙醇作替代提取媒介之可行性。方法 通过酪氨酸酶活性之抑制测试,并用曲酸作阳性对照,来评价个别中药水提物之有效程度。并将抑制作用明显较高的中药用80%乙醇提取,以和其水提物作一对比。结果 白水蔹提物的抑制作用最高,白芷及白及之水提物也有相当高的抑制效果。但白蔹、白芷及白及之80%乙醇提物抑制酪氨酸酶效果较差,其IC50比水提物之数值大5.9~23.8倍左右。结论 在提取白蔹、白芷及白及作美白用途时,在单纯考虑其提取物生物活性之基础上,水比80%乙醇为更好的提取媒介。 相似文献
525.
LIN Zen-Pin WANG Chung-Yuan JANO Tsong-Rong MA Tso-chiang CHIA Fan LIN Jaung-Geng HSU Jen-Jeng HO Tsung-Jung 《中华医学杂志(英文版)》2006,122(1):1587-1590
Boxing is an official sport at the 2008 Beijing Olympic Games and the fast development of world-class high strength training and sport science has made a significant impact on scientific training. Boxing needs high cardio-respiratory function, speed, muscle strength, and anaerobic and intensive physical demands including weight control covering the grading of athlete's. 相似文献
526.
MYUNG HO JEONG M.D. YOUN KEUN AHN M.D. JEONG GWAN CHO M.D. JONG CHUN PARK M.D. KOOK JOO NA M.D. JUNG CHAEE KANG M.D. 《Journal of interventional cardiology》2000,13(3):191-195
With the introduction of high pressure balloon inflations and antiplatelet therapy, the incidence of stent thrombosis has been markedly reduced, but the incidence of late stent restenosis has not. A new strategy may be local drug delivery, which maintains sustained local concentration and limits systemic complications. To evaluate the efficacy of local nitric oxide (NO) donor delivery on stent thrombosis and complications, local NO donor delivery was performed in stented patients. NO donor (2.0-mg molsidomine) was delivered (1.0 mL/min > 10 min) using the Dispatch Catheter after predilation of target lesions in 13 patients (6 angina, 7 myocardial infarction, age 53.1 ± 11.4 years). After local NO donor delivery, Palmaz-Schutz stents were placed using standard methods. Follow-up coronary angiograms were performed 48 hours and 6 months after stenting. None of the patients had hypotensive effects, ischemic symptoms, or ECG changes during and after local NO donor delivery. APTT and CK values were unchanged at 3 and 24 hours after local NO donor delivery and stenting. Follow-up coronary angiograms at 48 hours and 6 months showed all stents patent with TIMI III flow and without intrastent thrombus. No target lesion revascularization and 100% event-free survival were observed during the 6-month clinical follow-up period. Intracoronary stenting may be performed safely and effectively by local NO donor delivery prior to stent implantation. 相似文献
527.