全文获取类型
收费全文 | 404篇 |
免费 | 31篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 7篇 |
妇产科学 | 3篇 |
基础医学 | 30篇 |
口腔科学 | 4篇 |
临床医学 | 24篇 |
内科学 | 174篇 |
皮肤病学 | 21篇 |
神经病学 | 40篇 |
特种医学 | 26篇 |
外科学 | 41篇 |
综合类 | 5篇 |
预防医学 | 6篇 |
眼科学 | 1篇 |
药学 | 25篇 |
中国医学 | 2篇 |
肿瘤学 | 31篇 |
出版年
2023年 | 9篇 |
2022年 | 18篇 |
2021年 | 27篇 |
2020年 | 24篇 |
2019年 | 15篇 |
2018年 | 13篇 |
2017年 | 19篇 |
2016年 | 12篇 |
2015年 | 17篇 |
2014年 | 24篇 |
2013年 | 17篇 |
2012年 | 26篇 |
2011年 | 20篇 |
2010年 | 9篇 |
2009年 | 6篇 |
2008年 | 21篇 |
2007年 | 26篇 |
2006年 | 23篇 |
2005年 | 12篇 |
2004年 | 8篇 |
2003年 | 14篇 |
2002年 | 15篇 |
2001年 | 8篇 |
2000年 | 6篇 |
1999年 | 5篇 |
1997年 | 9篇 |
1996年 | 2篇 |
1994年 | 4篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 9篇 |
1989年 | 10篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有443条查询结果,搜索用时 31 毫秒
101.
102.
Atsuo Yamada Ryota Niikura Shuntaro Yoshida Yoshihiro Hirata Kazuhiko Koike 《Digestive endoscopy》2015,27(7):721-726
Colonic diverticular bleeding is the most common cause of lower gastrointestinal bleeding. Colonoscopy can be used for both diagnosis and treatment of colonic diverticular bleeding. Identification of the stigmata of recent hemorrhage allows for various endoscopic hemostasis methods. Clipping, endoscopic band ligation, injection therapy, and thermal contact are available methods for endoscopic hemostasis. However, the optimal technique remains to be determined. Herein, we review the techniques and clinical outcomes of endoscopic hemostasis for colonic diverticular bleeding. 相似文献
103.
104.
105.
Shinya Yamamoto Mahoko Ikeda Fumie Fujimoto Koh Okamoto Yoshitaka Wakabayashi Tomoaki Sato Keita Tatsuno Toshikatsu Kaburaki Shuntaro Yoshida Shu Okugawa Kazuhiko Koike Kyoji Moriya 《Journal of infection and chemotherapy》2018,24(2):147-149
Candida lusitaniae is an uncommon cause of candidiasis in humans. Ocular manifestations of C. lusitaniae infection have not been reported. C. lusitaniae is either intrinsically resistant to amphotericin B or can acquire such resistance. We describe a case of bilateral endophthalmitis due to C. lusitaniae bloodstream infection in a liver transplant patient with rectal cancer. The patient suffered fungemia and endophthalmitis and was treated with liposomal amphotericin B. The isolate was identified as C. lusitaniae by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, the system based on biochemical tests, and sequencing of the internal transcribed spacer region. The minimal inhibitory concentrations were 0.06 μg/mL for amphotericin B and 2.0 μg/mL for fluconazole. Repeat blood cultures were negative and the endophthalmitis improved following treatment with liposomal amphotericin B. However, the treatment was changed to fluconazole due to nephrotoxicity. No recurrence occurred after completion of treatment. 相似文献
106.
107.
Kakehashi Hidenao Doi Takahiro Wada Misato Kamata Tooru Shima Noriaki Miyake Akari Nitta Atsushi Asai Ryutaro Fujii Shihoko Matsuta Shuntaro Sasaki Keiko Kamata Hiroe Nishioka Hiroshi Miki Akihiro Hasegawa Hiroshi Katagi Munehiro 《Forensic Toxicology》2022,40(1):75-87
Forensic Toxicology - N-tert-Butoxycarbonylmethamphetamine (BocMA), a masked derivative of methamphetamine (MA), converts into MA under acidic condition and potentially acts as a precursor to MA... 相似文献
108.
Shuntaro Morikawa Nagisa Komatsu Sonoko Sakata Akari Nakamura-Utsunomiya Satoshi Okada Toshihiro Tajima 《Clinical Pediatric Endocrinology》2015,24(3):135-138
Pseudohypoaldosteronism type 1 (PHA1) is a disease characterized by neonatal salt loss
due to aldosterone resistance. Two types of PHA1 are known: an autosomal recessive
systemic form and an autosomal dominant renal form. The cause of the renal form of PHA1 is
heterozygous mutations in NR3C2, which encodes the mineralocorticoid
receptor (MR). We encountered two female Japanese infants with the renal form of PHA1 and
analyzed NR3C2. The two patients had poor weight gain, and one was
developmentally delayed. Genetic analysis identified one novel mutation (c.492_493insTT,
p.Met166LeufsX8) and one previously reported mutation (p.R861X). The two produced a
premature stop codon, resulting in haploinsufficiency of the MR. In conclusion, genetic
analysis of NR3C2 is useful for diagnosis and planning therapeutic
strategies. 相似文献
109.
Miho Kanda Ryosuke Tateishi Haruhiko Yoshida Takahisa Sato Ryota Masuzaki Takamasa Ohki Jun Imamura Tadashi Goto Hideo Yoshida Keisuke Hamamura Shuntaro Obi Fumihiko Kanai Shuichiro Shiina Masao Omata 《Liver international》2008,28(9):1256-1263
Background: Extrahepatic metastasis of hepatocellular carcinoma (HCC) is of growing importance as the survival of patients has been improved owing to advances in treatments to intrahepatic lesions. Methods: To elucidate the incidence and risk factors of extrahepatic metastasis of HCC, we enrolled 1573 (1131 treatment‐naïve and 442 previously treated on referral) patients with HCC without extrahepatic tumour spread treated at the authors' department between 1990 and 2003. Patients received medical treatment including percutaneous ablation and transcatheter arterial chemoembolization, and followed by dynamic computed tomography (CT) or magnetic resonance imaging (MRI) and tumour markers every 3–4 months. Extrahepatic metastasis was diagnosed by plain X‐ray, CT, MRI and scintigraphy. Clinical parameters at the time of treatment to intrahepatic lesions were evaluated as a predictor of subsequent extrahepatic metastasis among the 1131 treatment‐naïve patients by Cox's proportional hazard model. Results: During the average observation period of 3.9 years, extrahepatic metastasis was diagnosed in 123 in the treatment‐naïve and 53 in the patients treated previously. The incidence rate of extrahepatic metastasis, as detected during the lifetime after medical treatment of HCC, was approximately 13% at 5 years. Multivariate analysis with Cox proportional hazard model revealed that positivity for viral markers, lager tumour diameter, multiple tumour nodules, presence of vascular tumour invasion and elevated tumour markers were associated with the development of extrahepatic metastasis. Conclusion: The incidence of extrahepatic metastasis of HCC diagnosed during clinical course was not frequent. Advanced intrahepatic lesions, presence of vascular tumour invasion, elevated tumour markers and presence of viral hepatitis were risk factors for extrahepatic metastasis. 相似文献
110.