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排序方式: 共有704条查询结果,搜索用时 46 毫秒
701.
Akitada Yogo Toshihiko Masui Shigeo Takaishi Kenji Masuo Ru Chen Yosuke Kasai Kazuyuki Nagai Takayuki Anazawa Sadanori Watanabe Satoko Sakamoto Akira Watanabe Ryosaku Inagaki Masahiro M. Nakagawa Seishi Ogawa Hiroshi Seno Shinji Uemoto Etsuro Hatano 《Cancer science》2023,114(4):1324-1336
Bile duct cancer (BDC) frequently invades the nerve fibers, making complete surgical resection difficult. A single tumor mass contains cells of variable malignancy and cell-differentiation states, with cancer stem cells (CSCs) considered responsible for poor clinical outcomes. This study aimed to investigate the contribution of autosynthesized dopamine to CSC-related properties in BDC. Sphere formation assays using 13 commercially available BDC cell lines demonstrated that blocking dopamine receptor D1 (DRD1) signaling promoted CSC-related anchorage-independent growth. Additionally, we newly established four new BDC patient-derived organoids (PDOs) and found that blocking DRD1 increased resistance to chemotherapy and enabled xenotransplantation in vivo. Single-cell analysis revealed that the BDC PDO cells varied in their cell-differentiation states and responses to dopamine signaling. Further, DRD1 inhibition increased WNT7B expression in cells with bile duct-like phenotype, and it induced proliferation of other cell types expressing Wnt receptors and stem cell-like signatures. Reagents that inhibited Wnt function canceled the effect of DRD1 inhibition and reduced cell proliferation in BDC PDOs. In summary, in BDCs, DRD1 is a crucial protein involved in autonomous CSC proliferation through the regulation of endogenous WNT7B. As such, inhibition of the DRD1 feedback signaling may be a potential treatment strategy for BDC. 相似文献
702.
Takashi Yanagihara Masashi Shimohira Masanori Inoue Keita Nakayama Masashi Tamura Seishi Nakatsuka Hideo Hattori Katsura Emoto Keisuke Yokota Katsuhiro Okuda Ryoichi Nakanishi Kaoru Kaseda Chihaya Maeda Keisuke Asakura Akio Hiwatashi 《Radiology Case Reports》2022,17(6):2101
Coil embolization is widely performed for pulmonary arteriovenous malformations (PAVMs). We describe herein 2 cases of hemoptysis during long-term follow-up after coil embolization for PAVMs. For both cases, lobectomy was performed and histopathological examinations revealed chronic inflammation and bronchial epithelium extension into the sac of the PAVM. In addition, we performed a systematic review of previous reports of hemoptysis after embolization for PAVMs. 相似文献
703.
Takahiro Fukushima MD Shotaro Chubachi MD Ho Namkoong MD Takanori Asakura MD Hiromu Tanaka MD Ho Lee MD Shuhei Azekawa MD Yukinori Okada MD Ryuji Koike MD Akinori Kimura MD Seiya Imoto PhD Satoru Miyano PhD Seishi Ogawa MD Takanori Kanai MD Koichi Fukunaga MD The Japan COVID- Task Force 《Diabetes, obesity & metabolism》2023,25(1):144-155
704.
Osamu Yokota Tomoko Miki Hideki Ishizu Takashi Haraguchi Yuki Kishimoto Shintaro Takenoshita Norikazu Hara Akinori Miyashita Takeshi Ikeuchi Seishi Terada Norihito Yamada 《Neuropathology》2023,43(1):51-71
Argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP) and corticobasal degeneration are four-repeat (4R) tauopathies that develop in the presenium or later. Whether these diseases are associated with the occurrence of late-onset psychiatric disorders remains unclear. To facilitate the accumulation of clinicopathological findings regarding this issue, we here present a selected series of 11 cases that clinically developed psychotic disorder (n = 7; age at onset: 41–75 years), depressive disorder (n = 1; 49 years), bipolar disorder (n = 2; 32 and 37 years) and somatoform disorder (n = 1; 88 years), and had at least one pathological hallmark of these tauopathies. The mean age at death was 74.3 years. No case showed dementia, at least in the early stage of the course. Nine cases had AGD. Granular fuzzy astrocytes in the amygdala were noted in all AGD cases and one non-AGD case. Two AGD cases had tufted astrocytes (TAs) in the amygdala but not in the frontal cortex and striatum. Three AGD and two non-AGD cases had TAs in the frontal cortex and/or striatum but not in the amygdala. One AGD case had a small number of astrocytic plaques in the frontal cortex, striatum and globus pallidus. Only one case was diagnosed as atypical PSP according to the NINDS-PSP neuropathological criteria. No case had high-level Alzheimer's disease pathology, Lewy body disease or limbic-predominant age-related TDP-43 encephalopathy. Two cases had mild neuronal loss in the hippocampus and substantia nigra, respectively. Clinicopathological studies focusing especially on early changes of 4R tauopathies, as well as the development of surrogate markers of these diseases, may be necessary for better understanding of the pathogenic backgrounds of late-onset psychiatric disorders. 相似文献