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排序方式: 共有1231条查询结果,搜索用时 15 毫秒
91.
Aslan G Irer B Tuna B Yorukoglu K Saatcioglu F Celebi I 《Pathology, research and practice》2006,202(2):93-98
This study aimed to analyze NKX3.1 expression in tissue samples of benign prostate hyperplasia (BPH) and in three different prostate cancer categories. The correlation of NKX3.1 expression with clinical and pathologic features of patients having undergone radical prostatectomy also was investigated. NKX3.1 expression was determined in tissue samples obtained from four different histopathological categories: (1) from patients treated with transurethral prostatectomy for BPH (n = 26), (2) localized prostate cancer patients subjected to radical prostatectomy (n = 38), (3) biopsy samples from prostate cancer patients who were metastatic at the initial admission (n = 10), and (4) tissue samples of prostate cancer patients administered antiandrogens, but who had undergone transurethral prostatectomy for infravesical obstruction (n = 11). Standard immunohistochemical staining was performed using an antiserum raised against recombinant human NKX3.1. Staining was seen in all categories of prostatic tissues. Immunohistochemistry staining scores were lower in prostate cancer patients. The staining scores were significantly higher in patients with BPH compared to metastatic or localized prostate cancer patients. Staining scores of patients with BPH and of those under antiandrogen therapy were similar. No significant correlation was found between NKX3.1 expression and tumor volume, Gleason sum scores, the presence of extraprostatic extension, tumor stage, or serum PSA. NKX3.1 expression is significantly decreased in prostate cancer patients when compared to BPH. However, the decline of NKX3.1 expression was not correlated with prostate cancer progression and was not associated with advanced stage. Thus, NKX3.1 expression is not a clinically valuable prognostic factor. 相似文献
92.
Savas Yakan Safak Oztürk Mustafa Harman Oktay Tekesin Ahmet Coker 《Central European Journal of Medicine》2010,5(1):136-139
Gossypiboma (retained surgical sponge) is a pseudotumor within the body that is composed of non-absorbable surgical material
with a cotton matrix. Because the symptoms of gossypiboma usually are nonspecific and may appear years after surgery, the
diagnosis of gossypiboma may be difficult because the condition may mimic a benign or malignant soft-tissue tumour in the
abdomen and pelvis. A 61-year-old woman with a one-year history of left upper-quadrant pain and weight loss was referred to
our center. She had undergone peptic ulcer perforation 23 year ago. Physical examination revealed dullness and palpable mass
in the left upper abdomen. On examination by computed tomography (CT), a hypodense mass of 12 cm in diameter between the greater
curvature of the stomach, pancreas, and splenic hilus was detected. Upon exploration, a mass lesion of 10 cm in diameter was
detected between the greater curvature of the stomach and splenic hilus, which caused dense adhesions not in communication
with the pancreas. It was excised and a splenectomy was performed. After a macroscopic examination, the mass lesion was diagnosed
as gossypiboma. Although ultrasonography (US), CT, angiography, and magnetic resonance imaging (MRI) may be used to diagnose
gossypiboma, definitive diagnosis is possibile only upon surgery or histopathological examination. As a result, when an abdominal
mass is observed, surgeons should carefully investigate the patient’s past surgical history while taking the possibility of
gossypiboma into consideration. 相似文献
93.
Ugur Haklar Tolga Tuzuner Ilyas Uygur Baris Kocaoglu Osman Guven 《Knee surgery, sports traumatology, arthroscopy》2008,16(7):651-654
Our goal was to determine the primary stability of overlapping osteochondral grafts used in mosaicplasty by studying the effect of overlapping in an ex vivo model. Osteochondral grafts, 10 mm in diameter, were transplanted from the trochlea of cow femurs to the weight-bearing area of the lateral femoral condyle with 0, 15, or 30% overlap. The grafts were pushed in with a probe at a rate of 2 mm/min, and load (N)-displacement (mm) curves were recorded. In Group I (control, 0% overlap), insertion 1 and 2 mm below the cartilage level could be reached at 572.3 +/- 273.6 and 999.3 +/- 427.6 N, respectively. In Group II (15% overlap), insertion 1 and 2 mm below the cartilage level could be reached at 263.6 +/- 91.7 and 746.6 +/- 88.0 N, respectively. In Group III (30% overlap), insertion 1 and 2 mm below the cartilage level could be reached at 179.4 +/- 31.2 and 657.0 +/- 106.5 N, respectively. The loads that were necessary to produce a 1-mm dent in the grafts were significantly different between Groups I and II and Groups I and III (p < 0.05). These results suggest that stability may be reduced by graft overlapping in mosaicplasty surgery. The results of this ex vivo animal study contribute to a more complete understanding of the primary stability of osteochondral grafts in an overlapping position as well as postoperative protocols. 相似文献
94.
95.
96.
Twenty-two new 2,6,6-trimethyl-3-acetyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline+ ++ derivatives (compounds 1-22) have been prepared. The structures of the compounds were characterised by IR, 1H-NMR, mass spectroscopy and elemental analyses. The calcium antagonistic activities of the compounds were determined by the tests performed on isolated rabbit ileum and lamb carotid artery. According to the isolated rabbit ileum activity tests the most active compounds are 10 and 12 and according to the lamb carotid activity tests the most active compounds are 6 and 10. 相似文献
97.
Ring avulsion injury presents a spectrum of injury and the treatment varies accordingly from simple suture to amputation. In the current patient, we present a case that has a ring avulsion injury with intact bones, pulleys, flexor tendons, and one digital artery. The problems were venous insufficiency on nearly total avulsed skin and mallet type deformity due to extensor tendon laceration. The avulsed finger skin was sutured in place with interrupted skin sutures and leeches were applied to relieve venous congestion. The result was satisfactory. 相似文献
98.
99.
This study was conducted to evaluate the demographic, causative, and biologic characteristics of patients with organophosphate
(OP) poisoning who were admitted to tertiary teaching and research hospitals at 2 different universities. All patients admitted
to the emergency departments of Cukurova University Hospital in Adana, Turkey, between 2001 and 2003 and the Hospital of Mustafa
Kemal University in Hatay, Turkey, between 2004 and 2006 were included. The study group consisted of subjects with a mean
age of 28.5±14.1 y (range, 14–80 y), and the maximum number of cases in the second decade of life; the female-to-male ratio
was 2.2:1. In all, 27 of 43 females and 16 of 20 males were married. Most subjects (n=55) had graduated from primary school;
3 were illiterate and 5 were highly educated. A total of 36 (57.1%) subjects belonged to lower socioeconomic groups. Fifty-three
patients intended to commit suicide, and 10 cases were accidental. Mean arrival time of subjects to the hospital after poisoning
was 9.9±16.1 h (range, 1–96 h); mean Glasgow Coma Scale score was 10.2±2.9 (range, 3–15). A total of 19 subjects were intubated,
and 4 died. A total of 59 patients recovered completely. The mortality rate (6.3%) depended on various factors such as OP
compound consumed, amount ingested, time interval before hospitalization, and patients’ general health. Chances for recovery
were greater when the patient was hospitalized at the earliest indication. In conclusion, OPs especially affected young single
females, and most cases were due to attempted suicide. Because OP poisoning is an important cause of morbidity and mortality,
therapy should be started immediately to avoid undesirable consequences. 相似文献
100.
Buyukbese MA Koksal N Guven A Cetinkaya A 《The Tohoku journal of experimental medicine》2004,204(3):173-178
In Turkey, "Maras Powder," which is a kind of powder yielded from the shields of tobacco, is widely used as smokeless tobacco through buccal mucosa or together with cigarette. Maras powder, composed of ash and a plant named Nicotiana Rustica Linn, is sometimes used to give up smoking. The present study was aimed to investigate the effects of Maras powder use on respiratory functions of healthy subjects who do not have any chronic disease. We found statistically significant differences in percentage of forced expiratory volume in the first second (FEV(1)%) (p = 0.001), the ratio of FEV(1) to forced vital capacity (FEV(1)/FVC) (p = 0.024), percent of maximum expiratory flow rate (FEF(25-75)%) (p = 0.002) and percent of peak expiratory flow (PEF%) (p = 0.037) between cigarette smokers with Maras powder use (n = 23) and control subjects (n = 24). Likewise, when cigarette smokers (n = 24) and control subjects were compared, the differences for all these parameters were significant (p = 0.022, p = 0.048, p = 0.011 and p = 0.047, respectively). Only FEV(1)% and FEF(25-75)% were significantly lower in cigarette smokers with Maras powder use than in Maras powder users (n = 28) (p = 0.011 and p = 0.022, respectively). There was a negative correlation between forced vital capacity and Maras powder use (r = -0.315, p = 0.03). The present study suggests that Maras powder does not cause serious bronchial obstruction. This may be due to usage of the smokeless tobacco through buccal mucosa but not through inhalation as in case of cigarette smoking. 相似文献