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91.
92.
SV Suryanarayana Deo Bidhu K Mohanti Nootan K Shukla Sheema Chawla Vinod Raina Pramod K Julka Gouya K Rath 《Journal of Medical Imaging and Radiation Oncology》2001,45(1):35-38
Breast conservation therapy for early breast cancer is an established but grossly under‐utilized treatment option in India for various reasons. Breast conservation therapy was offered to 200 suitable breast cancer patients between June 1993 and June 1998. Fifty‐one patients (25%) opted for breast conservation and the remaining preferred mastectomy. In patients agreeing to conservation therapy, surgery was performed first along with peroperative implantation of iridium‐192 to deliver a boost. Whole breast irradiation of 45 Gy was delivered 3–4 weeks after the boost. Cosmesis was assessed at the end of 6 months from completion of therapy. The main reason for refusal of breast conservation therapy was fear of recurrence in the remaining breast (60%). There were no locoregional failures in our study at a median follow up of 42 months; one patient experienced a systemic relapse. Cosmesis was good to excellent in 80% of patients. Breast conservation therapy using peroperative iridium‐192 implant provides excellent locoregional disease control and cosmesis. The results of our study indicate that patient preference for mastectomy is an important reason for the under‐utilization of breast conservation therapy in India. 相似文献
93.
T Sagvolden T DasBanerjee Y Zhang-James FA Middleton SV Faraone 《Behavioral and brain functions : BBF》2008,4(1):56
Background
According to DSM-IV there are three subtypes of Attention-Deficit/Hyperactivity Disorder, namely: ADHD predominantly inattentive type (ADHD-PI), ADHD predominantly Hyperactive-Impulsive Type (ADHD-HI), and ADHD combined type (ADHD-C). These subtypes may represent distinct neurobehavioral disorders of childhood onset with separate etiologies. The diagnosis of ADHD is behaviorally based; therefore, investigations into its possible etiologies should be based in behavior. Animal models of ADHD demonstrate construct validity when they accurately reproduce elements of the etiology, biochemistry, symptoms, and treatment of the disorder. Spontaneously hypertensive rats (SHR) fulfill many of the validation criteria and compare well with clinical cases of ADHD-C. The present study describes a novel rat model of the predominantly inattentive subtype (ADHD-PI). 相似文献94.
95.
Anoop Jain Justin Rodgers Zhihui Li Rockli Kim SV Subramanian 《Maternal & child nutrition》2021,17(3)
Prior research has identified a number of risk factors ranging from inadequate household sanitation to maternal characteristics as important determinants of child malnutrition and health in India. What is less known is the extent to which these individual‐level risk factors are geographically distributed. Assessing the geographic distribution, especially at multiple levels, matters as it can inform where, and at what level, interventions should be targeted. The three levels of significance in the Indian context are villages, districts, and states. Thus, the purpose of this paper was to (a) examine what proportion of the variation in 21 risk factors is attributable to villages, districts, and states in India and (b) elucidate the specific states where these risk factors are clustered within India. Using the fourth National Family Health Survey dataset, from 2015 to 2016, we found that the proportion of variation attributable to villages ranged from 14% to 63%, 10% to 29% for districts and 17% to 62% for states. Furthermore, we found that Bihar, Jharkhand, Madhya Pradesh, and Uttar Pradesh were in the highest risk quintile for more than 10 of the risk factors included in our study. This is an indication of geographic clustering of risk factors. The risk factors that are clustered in states such as Bihar, Jharkhand, Madhya Pradesh and Uttar Pradesh underscore the need for policies and interventions that address a broader set of child malnutrition determinants beyond those that are nutrition specific. 相似文献
96.
R Harnagle Col Health & Senior Advisor Brig R Bhalwar SV Bhaskar 《Medical Journal Armed Forces India》2010
Background: Older people including ex-servicemen (ESM) in India are left to fend for themselves due to nuclear family system. Most children are not staying with them due to reasons such as acquiring of education or employment at distant places. These factors, coupled with deteriorating health with advancing age, change in value system and attitude amongst children who give more importance to materialism, it was felt necessary to find modalities to empower and strengthen ESM by available methods of including progressive weight training, yoga and meditation. 相似文献
97.
Protein S is a cofactor for activated protein C neutralization of an inhibitor of plasminogen activation released from platelets 总被引:2,自引:0,他引:2
Platelets stimulated with thrombin release an inhibitor of plasminogen activator (PAI), which has been shown previously to be neutralized by activated protein C (APC). The requirements for optimal neutralization of PAI activity were investigated. The releasate of gel-filtered human platelets stimulated with thrombin served as a source of PAI. When 6 X 10(8) platelets/mL were incubated with thrombin (1 IU/mL), the releasate contained 18 to 26 ng/mL PAI as determined by incubation of the releasate with urokinase and measurement of residual urokinase activity on plasminogen (S2251). Preincubation of PAI with up to 4 micrograms/mL APC for two hours yielded less than 20% neutralization of PAI activity. In the presence of protein S, phospholipid, and Ca2+, neutralization of PAI activity was time-dependent with 50% neutralization occurring in two hours with 1 microgram/mL APC. The cofactor effects of protein S and phospholipid were concentration- dependent with half-maximal acceleration at approximately 3 micrograms/mL protein S and 10 micrograms/mL phospholipid when the experiments were performed at 1 microgram/mL APC. Diisopropylfluorophosphate-inactivated APC, gla-domainless APC, and thrombin-cleaved protein S had no effect on PAI activity, indicating requirement for preservation of the APC active site and of the Ca2+ binding ability of both APC and protein S. These results suggest coordinate binding of APC and protein S onto phospholipid membrane as a prerequisite for optimal expression of PAI neutralized by APC. 相似文献
98.
Liu Y; Egyhazi S; Hansson J; Bhide SV; Kulkarni PS; Grafstrom RC 《Carcinogenesis》1997,18(10):1889-1895
Extracts prepared from tissue specimens of normal, non-tumourous human
buccal mucosa, and cultured buccal epithelial cells and fibroblasts,
exhibited O6-methylguanine-DNA methyltransferase (MGMT) activity by
catalysing the repair of the premutagenic O6-methylguanine lesion in
isolated DNA with rates of 0.2 to 0.3 pmol/mg protein. An SV40 T
antigen-immortalized buccal epithelial cell line termed SVpgC2a and a
buccal squamous carcinoma line termed SqCC/Y1, both of which lack normal
tumour suppressor gene p53 function, exhibited about 50 and 10% of the MGMT
activity of normal cells, respectively. The normal, experimentally
transformed and tumourous buccal cell types showed MGMT mRNA levels which
correlated with their respective levels of MGMT activity. Exposure of
buccal cell cultures to various organic or water- based extracts of
products related to the use of tobacco and betel quid, decreased both cell
survival (measured by reduction of tetrazolium dye) and MGMT activity
(measured subsequently to the exposures in cellular extracts). Organic
extracts of bidi smoke condensate and betel leaf showed higher potency than
those of tobacco and snuff. An aqueous snuff extract also decreased both
parameters, whereas an aqueous areca nut extract was without effect. The
well- established sulph-hydryl-reactive agent Hg2+, a corrosion product of
dental amalgam, served as a positive control and decreased MGMT activity
following treatment of cells within a range of 1-10 microM. Taken together,
significant MGMT activities were demonstrated in buccal tissue specimens
and in the major buccal mucosal cell types in vitro. Lower than normal MGMT
activity in two transformed buccal epithelial cell lines correlated with
decreased MGMT mRNA and lack of functional p53. Finally, in vitro
experiments suggested the potential inhibition of buccal mucosal MGMT
activity by complex mixtures present in the saliva of tobacco and betel nut
chewers.
相似文献
99.
100.
SV VATVE 《Medical Journal Armed Forces India》1997,53(4):301-302
Medical branches at formation headquarter and certain hospitals have taken into use Personal Computers (PCs) for data entry. Military Hospital Secunderabad has been progressing Project DHANWANTARI which is an on line medical information system. The type of network is host based to be developed into a Local Area Network (LAN). This article deals with concept of area networks and future scenario pertaining to computerisation of Armed Forces Medical Services (AFMS) hospitals.KEY WORDS: Armed Forces Medical Services, Local area network, Training 相似文献