全文获取类型
收费全文 | 12685篇 |
免费 | 936篇 |
国内免费 | 68篇 |
专业分类
耳鼻咽喉 | 287篇 |
儿科学 | 246篇 |
妇产科学 | 212篇 |
基础医学 | 1918篇 |
口腔科学 | 292篇 |
临床医学 | 1208篇 |
内科学 | 2738篇 |
皮肤病学 | 310篇 |
神经病学 | 1212篇 |
特种医学 | 813篇 |
外国民族医学 | 3篇 |
外科学 | 1715篇 |
综合类 | 141篇 |
一般理论 | 4篇 |
预防医学 | 810篇 |
眼科学 | 94篇 |
药学 | 884篇 |
中国医学 | 11篇 |
肿瘤学 | 791篇 |
出版年
2023年 | 46篇 |
2022年 | 102篇 |
2021年 | 247篇 |
2020年 | 127篇 |
2019年 | 204篇 |
2018年 | 250篇 |
2017年 | 206篇 |
2016年 | 280篇 |
2015年 | 365篇 |
2014年 | 406篇 |
2013年 | 529篇 |
2012年 | 865篇 |
2011年 | 909篇 |
2010年 | 497篇 |
2009年 | 478篇 |
2008年 | 838篇 |
2007年 | 883篇 |
2006年 | 800篇 |
2005年 | 826篇 |
2004年 | 795篇 |
2003年 | 773篇 |
2002年 | 687篇 |
2001年 | 160篇 |
2000年 | 129篇 |
1999年 | 168篇 |
1998年 | 160篇 |
1997年 | 171篇 |
1996年 | 125篇 |
1995年 | 116篇 |
1994年 | 102篇 |
1993年 | 102篇 |
1992年 | 81篇 |
1991年 | 78篇 |
1990年 | 65篇 |
1989年 | 84篇 |
1988年 | 54篇 |
1987年 | 62篇 |
1986年 | 66篇 |
1985年 | 53篇 |
1984年 | 67篇 |
1983年 | 59篇 |
1982年 | 74篇 |
1981年 | 56篇 |
1980年 | 59篇 |
1979年 | 46篇 |
1978年 | 35篇 |
1977年 | 35篇 |
1975年 | 40篇 |
1974年 | 34篇 |
1972年 | 30篇 |
排序方式: 共有10000条查询结果,搜索用时 515 毫秒
991.
Sheaff R Rogers A Pickard S Marshall M Campbell S Sibbald B Halliwell S Roland M 《Sociology of health & illness》2003,25(5):408-428
In many countries governments are recruiting the medical profession into a more active, transparent regulation of clinical practice. Consequently the medical profession adapts the ways it regulates itself and its relationship to health system managers changes. This paper uses empirical research in English Primary Care Groups (PCGs) and Primary Care Trusts (PCTs) to assess the value of Courpasson's concept of soft bureaucracy as a conceptualisation of these changes. Clinical governance in PCGs and PCTs displays important parallels with governance in soft bureaucracies, but the concept of soft bureaucracy requires modification to make it more applicable to general practice. In English primary care, governance over rank-and-file doctors is exercised by local professional leaders rather than general managers, harnessing their colleagues' perception of threats to professional autonomy and self-regulation rather than fears of competition as the means of 'soft coercion'. 相似文献
992.
Roland N Dickerson Angelina C Tidwell Rex O Brown 《Nutrition in clinical practice》2003,18(5):402-405
Numerous complications can arise when administering medications to patients receiving continuous enteral feeding. We report a case of a patient who could not be fed by mouth and was receiving continuous jejunal enteral feeding who had an adverse event associated with inappropriate administration of a medication via his jejunostomy tube. He had taken an extended-release niacin product before hospitalization for type IIb hyperlipidemia. The patient was inappropriately given a single dose of 750 mg of niacin as the short-acting tablets that were crushed and administered via the jejunostomy tube. He experienced severe cutaneous flushing, a feeling of warmth, itching, nausea, and emesis. He was noted to have "prickly heat" to the forehead, according to the nursing notes. A discussion of problems and guidelines for medication administration in adult patients receiving continuous tube feeding is provided. 相似文献
993.
994.
Vissers K Adriaensen H De Coster R De Deyne C Meert TF 《Anesthesia and analgesia》2003,97(2):520-5, table of contents
Application of four loose ligatures to the sciatic nerve of a rat (chronic constriction injury [CCI]) induces clear hypersensitivity to non-noxious stimulation and chemical irritants. However, in this study, an injection of formalin in the hind paw of a rat with CCI-induced mononeuropathy resulted in an ipsilateral decreased flinching and licking or biting behavior in both phases of the formalin testing. The effect was independent of the formalin concentration used. This altered behavior was accompanied with smaller plasma levels of adrenocorticotrope hormone and corticosterone compared with sham and non-operated animals. Formalin injection in the contralateral nonligated hind paw of CCI rats also reduced the licking or biting behavior as compared with sham-operated and non-operated control animals only in the second phase of the formalin test. Thus, CCI reduces the pain reactivity and hypothalamic-pituitary-adrenal-axis activation to ipsilateral and contralateral formalin injection. Further research should investigate whether the decreased pain reactivity by CCI is situated at the peripheral, spinal, or supraspinal level or is result of changes in the stress reactivity and coping strategies. IMPLICATIONS: We evaluated the changes in the behavioral reactions and the hormonal effects of a noxious chemical stimulus, i.e., formalin injection in animals with previously induced chronic constriction injury to the sciatic nerve. The effect in animals injected at the ipsilateral and contralateral site, sham-operated and controls, were compared. 相似文献
995.
Potapov EV Weng Y Hausmann H Kopitz M Pasic M Hetzer R 《The Annals of thoracic surgery》2003,76(6):2112-2114
In 12 patients with acute cardiogenic shock who required mechanical circulatory support a short-term Abiomed BVS 5000 extracorporeal assist device was implanted using the inflow and outflow cannulas of the BerlinHeart extracorporeal assist device. In 7 patients suitable for long-term support the Abiomed pumps were later exchanged for BerlinHeart pumps. This approach avoids the risks associated with repeat sternotomy and use of cardiopulmonary bypass and decreases the total costs of patient care. 相似文献
996.
Karssemeijer N Otten JD Verbeek AL Groenewoud JH de Koning HJ Hendriks JH Holland R 《Radiology》2003,227(1):192-200
PURPOSE: To evaluate the use of a computer-aided detection (CAD) system (designed for mammographic mass detection) to help improve mass interpretation and to compare CAD results with independent double-reading results. MATERIALS AND METHODS: Screening mammograms from 500 cases were collected; 125 of these cases were screening-detected cancers, and 125 were interval cancers. Previously obtained screening mammograms (ie, prior mammograms) were available in all cases. All mammograms were analyzed by a CAD system, which detected mass regions and assigned a level of (cancer) suspicion to each mass. Ten experienced screening radiologists read the prior mammograms. For independent interpretation with CAD, the suspicion rating assigned to each finding by the radiologist was weighted with the CAD output at the area of the finding. CAD markers on areas that were not reported by the radiologist were not used. Independent double reading was implemented by using a rule to combine the levels of suspicion assigned to findings by two radiologists. Results were evaluated by using localized-response receiver operating characteristic analysis. RESULTS: In a total of 141 cases, there was a visible abnormality at the location of the cancer on the prior mammogram, and 115 of these were classified as mass cases. For prior mammograms that depicted masses, the mean sensitivity of the radiologists, as averaged among the false-positive rates lower than 10%, was 39.4%; this increased by 7.0% with CAD and by 10.5% with double reading. Differences among single, double, and CAD readings were statistically significant (P <.001). CONCLUSION: Although independent double reading yields the best detection performance, the presence and probability of CAD mass markers can improve mammogram interpretation. 相似文献
997.
Crisafulli A Scott AC Wensel R Davos CH Francis DP Pagliaro P Coats AJ Concu A Piepoli MF 《Medicine and science in sports and exercise》2003,35(2):221-8; discussion 229
PURPOSE: Accumulation of by-products of metabolism within skeletal muscle may stimulate sensory nerves, thus evoking a pressor response named muscle metaboreflex. The aim of this study was to evaluate changes in central hemodynamics occurring during the metaboreflex activation. METHODS: In seven healthy subjects, the metaboreflex was studied by postexercise regional circulatory occlusion at the start of the recovery from a mild rhythmic forearm exercise. Central hemodynamics was evaluated by means of impedance cardiography. RESULTS: The main findings of this study were that, with respect to rest, the metaboreflex: 1) raised mean blood pressure (+13%; P < 0.01); 2) enhanced myocardial contractility (-12% in preejection period/left ventricular ejection time ratio; P < 0.01); 3) prolonged diastolic time (+11%; P < 0.01); 4) increased stroke volume (+ 10%; P < 0.05); and 5) increased cardiac output (+6%; P < 0.05). These responses were present neither during recovery without circulatory occlusion nor during circulatory occlusion without prior exercise. Moreover, the metaboreflex did not affect systemic vascular resistance and induced bradycardia with respect to recovery without circulatory occlusion. CONCLUSION: These results suggest that the blood pressure response during metaboreflex activation after mild rhythmic exercise is strongly dependent on the capacity to increase cardiac output rather than due to increased vascular resistance. 相似文献
998.
Line scan diffusion imaging of the spine 总被引:6,自引:0,他引:6
Bammer R Herneth AM Maier SE Butts K Prokesch RW Do HM Atlas SW Moseley ME 《AJNR. American journal of neuroradiology》2003,24(1):5-12
BACKGROUND AND PURPOSE: Recent findings suggest that diffusion-weighted imaging might be an important adjunct to the diagnostic workup of disease processes in the spine, but physiological motion and the challenging magnetic environment make it difficult to perform reliable quantitative diffusion measurements. Multi-section line scan diffusion imaging of the spine was implemented and evaluated to provide quantitative diffusion measurements of vertebral bodies and intervertebral disks. METHODS: Line scan diffusion imaging of 12 healthy study participants and three patients with benign vertebral compression fractures was performed to assess the potential of line scan diffusion imaging of the spinal column. In a subgroup of six participants, multiple b-value (5-3005 s/mm(2)) images were obtained to test for multi-exponential signal decay. RESULTS: All images were diagnostic and of high quality. Mean diffusion values were (230 +/- 83) x 10(-6) mm(2)/s in the vertebral bodies, (1645 +/- 213) x 10(-6) mm(2)/s in the nuclei pulposi, (837 +/- 318) x 10(-6) mm(2)/s in the annuli fibrosi and ranged from 1019 x 10(-6) mm(2)/s to 1972 x 10(-6) mm(2)/s in benign compression fractures. The mean relative intra-participant variation of mean diffusivity among different vertebral segments (T10-L5) was 2.97%, whereas the relative difference in mean diffusivity among participants was 7.41% (P <.0001). The estimated measurement precision was <2%. A bi-exponential diffusion attenuation was found only in vertebral bodies. CONCLUSION: Line scan diffusion imaging is a robust and reliable method for imaging the spinal column. It does not suffer as strongly from susceptibility artifacts as does echo-planar imaging and is less susceptible to patient motion than are other multi-shot techniques. The different contributions from the water and fat fractions need to be considered in diffusion-weighted imaging of the vertebral bodies. 相似文献
999.
Puls R Stroszczynski C Gaffke G Hosten N Felix R Speck U 《Journal of magnetic resonance imaging : JMRI》2003,17(6):663-670
PURPOSE: To evaluate the efficacy and safety of a new MRI-compatible irrigated laser microcatheter system for thermal ablation of liver metastases. MATERIAL AND METHODS: The new microcatheter system consists of a titanium needle with a diameter of 1.5 mm and a surrounding Teflon catheter with an outer diameter of 1.8 mm (5.5 F). In vitro laser-induced coagulation of bovine liver tissue was performed to determine the optimal perfusion rate of cooling saline flow, maximum laser energy, and ablation time. Laser-induced thermotherapy using the new microcatheter system, an Nd:YAG laser (Dornier), and a flexible laser light guide (Somatex GmbH, Berlin, Germany) was performed in 28 patients with liver metastases. Percutaneous insertion and positioning of multiple microcatheters in the lesion and monitoring of therapy was performed with a closed high-field MRI scanner using T1-weighted gradient-echo sequences during breath-hold. RESULTS: A perfusion rate of 0.75 mL/minute, a laser energy of 15 W, and an ablation time of 20 minutes were found suitable to achieve safe and sufficient ablation of metastatic tissue. The mean volume of induced coagulation in vitro was 23.9 mL. Ablation of liver metastases in patients was technically and clinically successful. CONCLUSION: The new microcatheter system allows for both catheter placement and monitoring of therapy using a single imaging modality. This shortens the procedure and enables more precise puncture and therapy of liver metastases. Due to the miniaturized design of the catheter and the real-time monitoring, the procedure is minimally invasive and very well tolerated by patients. This new technique seems to be a safe and feasible alternative in treating liver metastases. 相似文献
1000.
Prospective evaluation of contrast-enhanced MRI in the depiction of peritoneal spread in primary or recurrent ovarian cancer 总被引:4,自引:2,他引:2
The purpose of this study was to assess the accuracy of MRI in the staging of intra-abdominal tumor seeding of ovarian carcinoma.
Fifty-seven patients with suspected primary or recurrent ovarian carcinoma were included in this study. All patients received
laparotomy within 8 weeks after MRI. The MRI protocol included fat-saturated T1-weighted spin-echo (SE) sequences pre- and
post i.v. application of gadopentetate dimeglumine. The criteria for tumor manifestation was contrast enhancement of intra-abdominal
soft tissue lesions or peritoneum. The image review was performed by a blinded radiologist, a specialist in gynecological
and abdominal MR imaging. Results were compared with findings during laparotomy. Sensitivity, specificity, positive and negative
predictive values, and corresponding 95% confidence intervals were calculated for single intra-abdominal locations and for
groups of locations defined according to surgical strategies for intra-abdominal cytoreduction. Laparotomy and histopathology
confirmed 251 abdominal tumor locations. Sensitivity was high in lower pelvis locations (73–83%) except for ureter or bladder
infiltration (40%). Bowel or mesentery locations displayed sensitivity values from 73 to 77%. Sensitivity was very low for
pelvic lymph nodes (28%), greater omentum (38%), and lesser sac (43%). Magnetic resonance imaging based on contrast-enhanced
fat-saturated T1 SE sequences improves planning of cytoreduction preceding chemotherapy in advanced primary or relapsed ovarian
carcinoma.
Electronic Publication 相似文献