首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1385篇
  免费   121篇
  国内免费   9篇
耳鼻咽喉   21篇
儿科学   75篇
妇产科学   12篇
基础医学   132篇
口腔科学   36篇
临床医学   134篇
内科学   328篇
皮肤病学   22篇
神经病学   35篇
特种医学   260篇
外科学   125篇
综合类   60篇
预防医学   90篇
眼科学   24篇
药学   53篇
中国医学   9篇
肿瘤学   99篇
  2021年   14篇
  2020年   14篇
  2019年   14篇
  2018年   20篇
  2017年   17篇
  2016年   14篇
  2015年   26篇
  2014年   49篇
  2013年   67篇
  2012年   51篇
  2011年   49篇
  2010年   51篇
  2009年   66篇
  2008年   45篇
  2007年   66篇
  2006年   44篇
  2005年   39篇
  2004年   29篇
  2003年   26篇
  2002年   27篇
  2001年   23篇
  2000年   22篇
  1999年   19篇
  1998年   87篇
  1997年   58篇
  1996年   66篇
  1995年   51篇
  1994年   56篇
  1993年   48篇
  1992年   14篇
  1991年   11篇
  1990年   17篇
  1989年   43篇
  1988年   31篇
  1987年   32篇
  1986年   26篇
  1985年   15篇
  1984年   22篇
  1983年   17篇
  1982年   15篇
  1981年   22篇
  1980年   15篇
  1979年   9篇
  1978年   9篇
  1977年   16篇
  1976年   9篇
  1975年   11篇
  1973年   4篇
  1971年   6篇
  1966年   4篇
排序方式: 共有1515条查询结果,搜索用时 0 毫秒
41.
Foon  KA; Nakano  GM; Koller  CA; Longo  DL; Steis  RG 《Blood》1986,68(1):297-300
Two patients with hairy cell leukemia with massive splenomegaly and severe pancytopenia were treated with recombinant alpha-A interferon (IFN-alpha-2a). There was no significant response to a trial of IFN- alpha-2a (11 and 20 weeks) with respect to blood counts or spleen size. Subsequent treatment with 2'-deoxycoformycin (dCF) for 8 consecutive weeks (4 mg/m2/wk) resulted in normalization of spleen size and a normalization of peripheral blood counts and bone marrow in one patient. The second patient demonstrated a reduction in spleen size and improved blood counts following 9 weeks of dCF therapy but eventually became refractory. This demonstrates that dCF is non-cross-resistant with interferon and confirms the efficacy of dCF in nonsplenectomized patients.  相似文献   
42.
牙列缺损的计算机三维建模   总被引:4,自引:5,他引:4  
目的 建立牙列缺损的计算机三维模型。方法 采用表面绘制法,依据CT扫描头颅骨标本获得的二维断层图像数据在3D Studio Max中沿牙体长轴放样、微调并赋以材质,得到牙列缺损的计算机三维模型。结果 能在计算机中方便快速地模拟任意类型的牙列缺损,并可全方位地旋转、放大和缩小。结论 提供了一种牙列缺损三维建模的新方法,有利于三维义齿专家系统的开发和计算机辅助教学。  相似文献   
43.
44.
“I have noticed in operations of this kind, which I have seen performed by others upon the living, and in a number of excisions, which I have myself performed on the dead body, that most of the difficulty in the separation of the tumor has occurred in the region of these ligaments…. This difficulty, I believe, to be a very frequent source of that accident, which so commonly occurs in removal of goiter, I mean division of the recurrent laryngeal nerve.” Sir James Berry (1887)  相似文献   
45.
目的探讨经关节入路微创钢板固定(MIPPO)技术治疗股骨远端C型骨折的临床疗效。方法2002年4月~2005年2月,应用MIPPO技术治疗股骨远端C型骨折14例,按AO/ASIF分类:C1型3例,C2型6例,C3型5例。先行关节内骨折切开复位、松质骨螺钉固定,再行髁上部分骨折间接复位、经关节内切口插入髁支撑钢板或LISS钢板桥接固定骨折。结果12例患者获得10~32个月(平均18.4个月)随访,骨折均获愈合,愈合时间10周~12个月,平均4.6个月。按Kolmert和Wulff的评价标准:优4例,良5例,可2例,差1例,优良率为75%。结论应用MIPPO技术治疗股骨远端C型骨折实现了微创操作,具有创伤小、软组织干扰少、骨折愈合快等优点,疗效满意。  相似文献   
46.
EBP can be used by radiologists to assess imaging modalities using the recognized “Ask, Search, Appraise, Apply, and Evaluate” steps. The technology assessment framework is also a useful tool to stratify an imaging modality according to its technical and diagnostic performance. It can also be used to assess its therapeutic and diagnostic impact as part of the “Evaluate” step of EBP. We have described how these two processes can be combined and used in a synergistic way. While its format may appear unorthodox compared to conventional research methodology (i.e., aims, methods, results, and conclusion), it is a practical and readily interpreted way of bridging the gap between EBP and primary research. An example of its application entitled “Combining ‘Evidence-Based Practice’ and ‘Technology Assessment’ Methods to Develop Departmental Imaging Protocols: Should FDG PET Be Routinely Used in the Preoperative Assessment of Patients With Colorectal Liver Metastases?” is published in this issue. Further details of this process and its potential impact on technology assessment, education, ethics, and radiology literature has been considered in a recent Radiology special series (11).  相似文献   
47.
High-dose intravenous gammaglobulin (polyvalent immunoglobulin G) has been shown to be of benefit in some patients with immune thrombocytopenic purpura (ITP), possibly by producing reticuloendothelial system blockade. We studied this approach in patients refractory to random donor platelet transfusion using an IV IgG preparation manufactured by the Swiss Red Cross. Eleven adult patients with acute leukemia received either 0.4 g IgG/kg/d intravenously X five days (four patients) or 0.6 g/kg/d X five days (seven patients). All patients had high levels of lymphocytotoxic antibody and poor responses to random donor platelets. Except for mild headaches in two patients, there were no side effects related to the IgG infusions. All patients had significant elevations of serum IgG on the day after completion of treatment. Either random donor or partially HLA-matched platelet transfusions were administered the day after and, in some cases, during the IgG therapy. No patient had an improvement in one hour posttransfusion platelet count increments. Two additional patients received pooled platelet concentrates incubated for 30 minutes at 37 degrees C with IgG at a final concentration of 3 g% prior to transfusions. These results indicate that high-dose IgG, an extremely expensive treatment, cannot be recommended for alloimmunized adults with leukemia.  相似文献   
48.
49.
Primary Autosomal Recessive Microcephaly (MCPH) is characterized by congenital microcephaly usually without additional clinical findings. The most common gene implicated in MCPH is ASPM and a large percentage of mutations described have been homozygous and in consanguineous families primarily of East Asian and Middle Eastern origin. ASPM sequencing was performed on 400 patients between the years 2009 and 2012. Seventy of the patient samples were also analyzed for copy number changes in the ASPM gene. Forty protein truncating mutations, including 29 novel mutations, were identified in 39 patients with MCPH. Approximately one third of patients were compound heterozygotes, indicative of non‐consanguinity in these patients. In addition, 46 non‐synonymous variants were identified and interpreted as variants of uncertain significance. No deletion/duplication in ASPM was identified in the patients analyzed. A wide ethnic distribution was observed, including the first reported patients with ASPM‐related MCPH of Hispanic descent. Clinical information was collected for 26 of the ASPM‐positive patients and 41 of the ASPM‐negative patients. As more individuals are identified with MCPH, we anticipate that we will continue to identify ASPM mutation‐positive patients from all ethnic origins supporting the occurrence of this genetic condition beyond that of consanguineous families of certain ethnic populations.  相似文献   
50.
目的 白细胞介素 1 3(IL 1 3)是新近发现的一种抗炎性细胞因子 ,其在肾小球肾炎中的作用尚不清楚 ,该研究探讨脂多糖 (LPS)对体外培养的人肾小球系膜细胞 (HMC)表达IL 1 3作用以及IL 1 3对HMC促炎性细胞因子、趋化因子和促纤维化因子基因表达的影响。方法 体外培养HMC ,加入不同浓度的LPS和 (或 )IL 1 3后 ,用逆转录 -聚合酶链反应和ELISA检测HMCIL 1 3mRNA表达和细胞培养上清液中IL 1 3蛋白含量 ;应用核酸酶保护法检测HMC肿瘤坏死因子 α(TNF α)、白介素 - 1α(IL 1α)、白介素 - 1 β(IL 1 β)、单核细胞趋化蛋白 1(MCP 1 )、白介素 8(IL 8)、转化生长因子 - β1 (TGF β1 )mRNA的表达。 结果 未予LPS刺激的HMC不表达IL 1 3mRNA和蛋白 ;LPS呈剂量依赖性和时间依赖性诱导HMC表达IL 1 3mRNA和分泌IL 1 3蛋白。HMC受LPS刺激后 1 2h即可表达IL 1 3mRNA ,4 8h达高峰 ,72h仍维持在较高的水平。HMC受LPS刺激后 2 4h ,其培养上清液中检测到IL 1 3蛋白 ,4 8h和 72h进一步增加。外源性IL 1 3呈剂量依赖性地抑制LPS诱导的系膜细胞TNF α ,IL 1α ,IL 1 β ,MCP 1 ,IL 8,TGF β1mRNA的表达。应用抗IL 1 3抗体中和内源性IL 1 3后 ,上述炎症因子表达增强。结论 IL 1 3是HMC自分泌因子。IL 1 3可抑制LPS诱导  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号