全文获取类型
收费全文 | 6482篇 |
免费 | 340篇 |
国内免费 | 62篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 192篇 |
妇产科学 | 143篇 |
基础医学 | 657篇 |
口腔科学 | 146篇 |
临床医学 | 441篇 |
内科学 | 1696篇 |
皮肤病学 | 126篇 |
神经病学 | 416篇 |
特种医学 | 393篇 |
外科学 | 1148篇 |
综合类 | 19篇 |
预防医学 | 220篇 |
眼科学 | 53篇 |
药学 | 299篇 |
中国医学 | 8篇 |
肿瘤学 | 878篇 |
出版年
2024年 | 6篇 |
2023年 | 89篇 |
2022年 | 109篇 |
2021年 | 253篇 |
2020年 | 156篇 |
2019年 | 224篇 |
2018年 | 278篇 |
2017年 | 171篇 |
2016年 | 198篇 |
2015年 | 202篇 |
2014年 | 310篇 |
2013年 | 359篇 |
2012年 | 506篇 |
2011年 | 523篇 |
2010年 | 286篇 |
2009年 | 251篇 |
2008年 | 404篇 |
2007年 | 387篇 |
2006年 | 347篇 |
2005年 | 405篇 |
2004年 | 340篇 |
2003年 | 310篇 |
2002年 | 264篇 |
2001年 | 40篇 |
2000年 | 34篇 |
1999年 | 44篇 |
1998年 | 64篇 |
1997年 | 46篇 |
1996年 | 38篇 |
1995年 | 32篇 |
1994年 | 28篇 |
1993年 | 23篇 |
1992年 | 12篇 |
1991年 | 10篇 |
1990年 | 17篇 |
1989年 | 13篇 |
1988年 | 16篇 |
1987年 | 8篇 |
1986年 | 18篇 |
1985年 | 10篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 7篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1975年 | 3篇 |
1904年 | 2篇 |
排序方式: 共有6884条查询结果,搜索用时 31 毫秒
991.
Marcin J Woźniak Riccardo Abbasciano Alexandra Monaghan Florence Y Lai Claudio Corazzari Cassandra Tutino Tracy Kumar Penny Whiting Gavin J Murphy 《Transfusion medicine reviews》2021,35(1):7-15
Treatment guidelines recommend the routine use of point-of-care diagnostic tests for coagulopathy in the management of cardiac surgery patients at risk of severe bleeding despite uncertainty as to their diagnostic accuracy. We performed a systematic review and meta-analysis of studies that evaluated the diagnostic accuracy of viscoelastometry, platelet function tests, and modified thromboelastography (TEG) tests, for coagulopathy in cardiac surgery patients. The reference standard included resternotomy for bleeding, transfusion of non-red cell components, or massive transfusion. We searched MEDLINE, EMBASE, CINAHL, and Clinical Trials.gov, from inception to June 2019. Study quality was assessed using QUADAS-2. Bivariate models were used to estimate summary sensitivity and specificity with (95% confidence intervals). All 29 studies (7440 participants) included in the data synthesis evaluated the tests as predictors of bleeding. No study evaluated their role in the management of bleeding. None was at low risk of bias. Four were judged as low concern regarding applicability. Pooled estimates of diagnostic accuracy were; Viscoelastic tests, 12 studies, sensitivity 0.61 (0.44, 0.76), specificity 0.83 (0.70, 0.91) with significant heterogeneity. Platelet function tests, 12 studies, sensitivity 0.63 (0.53, 0.72), specificity 0.75 (0.64, 0.84) with significant heterogeneity. TEG modification tests, 3 studies, sensitivity 0.80 (0.67, 0.89), specificity 0.76 (0.69, 0.82) with no evidence of heterogeneity. Studies reporting the highest values for sensitivity and specificity had important methodological limitations. In conclusion, we did not demonstrate predictive accuracy for commonly used point-of-care devices for coagulopathic bleeding in cardiac surgery. However, the certainty of the evidence was low. 相似文献
992.
Alessandro Zanforlin Andrea Smargiassi Riccardo Inchingolo Salvatore Valente Emilio Ramazzina 《Journal of Ultrasound》2015,18(4):379-384
The ultrasound study of the chest is showing a continuous development. This technique could be helpful in managing several chest diseases, but it is limited to the acoustic windows provided by intercostal spaces and by the inability to study healthy lung parenchyma and all intra-parenchymal diseases such as chronic obstructive lung disease (COPD), because the interaction between ventilated lung and ultrasound generates only artifacts. Currently, there are few applications of ultrasound that are useful in COPD, with recent studies providing some innovation potentially useful in clinical practice. The similarity of the trend between the time/volume curve of spirometry and the M-mode representation of diaphragm during forced breath allowed to identify the M-mode Index of Obstruction (MIO), an index obtained from the ratio between forced diaphragmatic excursion in the first second (FEDE1, cm) and the maximal expiratory diaphragmatic excursion (EDEMax, cm). MIO has shown a linear correlation with the ratio between forced expiratory volume in the first second (FEV1) and vital capacity (VC), used in spirometry to identify airways obstruction. The value of MIO seems to be lower in patients affected by airways obstruction as showed by a recent study. The technique is easy to learn and fast to perform and the analysis could be provided with any ultrasound machine equipped with M-mode. In conclusion, these findings, if confirmed by other studies, could suggest a new add-on screening tool for obstructive lung diseases, in particular COPD, that could be performed during a routine abdominal ultrasound exam. 相似文献
993.
994.
995.
996.
997.
Giammaria Fiorentini Donatella Sarti Camillo Aliberti Riccardo Carandina Luca Mulazzani Alessandro Felicioli Stefano Guadagni 《Journal of vascular and interventional radiology : JVIR》2018,29(9):1236-1239
Transarterial chemoembolization is an effective, minimally invasive therapy that is widely used for treatment of unresectable colorectal cancer liver metastases (CRC-LM). However, chemoembolization induces a hypoxic microenvironment, which increases neoangiogenesis and may promote early progression. For this reason, transarterial chemoembolization efficacy may be improved by combining it with an angiogenesis inhibitor, such as bevacizumab. This report shows that transarterial chemoembolization with irinotecan-loaded polyethylene glycol embolics and bevacizumab therapy was effective and well tolerated by 6 patients with CRC-LM, resulting in a disease control rate of 83% and an overall improvement in quality of life. 相似文献
998.
Brian M Alexander Paul D Brown Manmeet S Ahluwalia Hidefumi Aoyama Brigitta G Baumert Susan M Chang Laurie E Gaspar Steven N Kalkanis David R Macdonald Minesh P Mehta Riccardo Soffietti John H Suh Martin J van den Bent Michael A Vogelbaum Jeffrey S Wefel Eudocia Q Lee Patrick Y Wen 《The lancet oncology》2018,19(1):e33-e42
999.
Roberto Castelli Riccardo Schiavon Valentina Rossi Giorgio Lambertenghi Deliliers 《Medical oncology (Northwood, London, England)》2018,35(5):76
The myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders. The International Prognostic Score System (IPSS) groups MDS in lower-risk (IPSS low and intermediate-1) and higher-risk disease (IPSS intermediate-2 and high). AML transformation is the main concern in higher-risk MDS, while anemia and transfusion dependency represent the major issues for low-risk MDS patients. Improving erythropoiesis, and eliminating fatigue and symptoms, is the main therapeutic goal for low-risk MDS patients. Around 50% of MDS patients present with anemia with an Hb level <?100 g/L. Severe anemia increases the negative effects of comorbidities, such as heart and lung failure. Erythropoiesis-stimulating agents (ESAs), with or without granulocyte colony-stimulating factor, induce erythroid response rates in 40–50% of lower-risk anemic MDS patients. The median response duration of 24 months. Apoptosis of erythroid cells is inhibited by ESAs leading to erythrocyte production. Our paper considers the state of the art of treatment of anemia in low-risk MDS patients and the treatment options in MDS resistant or refractory to ESAs. 相似文献
1000.
Riccardo Schiavina Lorenzo Bianchi Federico Mineo Bianchi Marco Borghesi Cristian Vincenzo Pultrone Hussam Dababneh Paolo Castellucci Francesco Ceci Cristina Nanni Caterina Gaudiano Michelangelo Fiorentino Angelo Porreca Francesco Chessa Andrea Minervini Stefano Fanti Eugenio Brunocilla 《Clinical genitourinary cancer》2018,16(4):305-312.e1