全文获取类型
收费全文 | 24424篇 |
免费 | 1826篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 205篇 |
儿科学 | 765篇 |
妇产科学 | 637篇 |
基础医学 | 3334篇 |
口腔科学 | 371篇 |
临床医学 | 3145篇 |
内科学 | 4390篇 |
皮肤病学 | 291篇 |
神经病学 | 2509篇 |
特种医学 | 530篇 |
外科学 | 2488篇 |
综合类 | 382篇 |
一般理论 | 82篇 |
预防医学 | 3501篇 |
眼科学 | 246篇 |
药学 | 1449篇 |
中国医学 | 18篇 |
肿瘤学 | 1942篇 |
出版年
2024年 | 43篇 |
2023年 | 310篇 |
2022年 | 478篇 |
2021年 | 982篇 |
2020年 | 619篇 |
2019年 | 933篇 |
2018年 | 940篇 |
2017年 | 711篇 |
2016年 | 763篇 |
2015年 | 787篇 |
2014年 | 1022篇 |
2013年 | 1398篇 |
2012年 | 2135篇 |
2011年 | 2108篇 |
2010年 | 1121篇 |
2009年 | 902篇 |
2008年 | 1563篇 |
2007年 | 1487篇 |
2006年 | 1493篇 |
2005年 | 1344篇 |
2004年 | 1167篇 |
2003年 | 996篇 |
2002年 | 879篇 |
2001年 | 191篇 |
2000年 | 152篇 |
1999年 | 164篇 |
1998年 | 190篇 |
1997年 | 114篇 |
1996年 | 94篇 |
1995年 | 74篇 |
1994年 | 56篇 |
1993年 | 66篇 |
1992年 | 58篇 |
1991年 | 57篇 |
1990年 | 50篇 |
1989年 | 58篇 |
1988年 | 47篇 |
1987年 | 39篇 |
1986年 | 49篇 |
1985年 | 42篇 |
1984年 | 49篇 |
1983年 | 36篇 |
1982年 | 37篇 |
1981年 | 49篇 |
1980年 | 32篇 |
1979年 | 29篇 |
1978年 | 26篇 |
1977年 | 26篇 |
1975年 | 19篇 |
1972年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
31.
Rebecca Knight MD Erick R Ratzer MD FACS Michael E Fenoglio MD FACS John T Moore MD 《Journal of the American College of Surgeons》1997,185(5):481-485
Background:Most abnormal parathyroid glands can be removed through a standard cervical incision; even those in the superior mediastinum. Those located in certain areas of the mediastinum, for example posteriorly or in the aortopulmonic window, historically have required excision through a median sternotomy or thoracotomy. Angioablation is a nonsurgical alternative to management of these lesions.Study Design:We present two case reports of mediastinal parathyroid adenomas that were excised thoracoscopically, and review the literature regarding the management of mediastinal parathyroid adenomas.Results:Both patients who underwent precise localization and thoracoscopic excision of their mediastinal parathyroid adenomas had resolution of their hypercalcemia with minimal associated morbidity and shortened recovery periods.Conclusions:We suggest that thoracoscopic excision of mediastinal parathyroid adenomas is the better means of controlling hypercalcemia secondary to parathyroid adenoma in those patients considered for either median sternotomy, thoracotomy or angiographic ablation where the exact location of the lesion can be established preoperatively. 相似文献
32.
Hepatocyte isolation from pig livers after warm ischaemic injury 总被引:9,自引:0,他引:9
Michael R. Schön Gero Puhl Jörg Gerlach Jorn Frank Peter Neuhaus 《Transplant international》1994,7(S1):159-162
Abstract Hepatocyte cultures have been used extensively for a wide variety of physiological, pharmacological and experimental studies. The warm ischaemic period before isolation is kept to a minimum to achieve a high yield of cells isolated and a good viability for culture. We have recently introduced a new concept of liver resuscitation after warm ischaemia that is based on a 3-h reperfusion period with an improved perfusate and simultaneous dialysis. In this study, we applied the new technique for hepatocyte isolation from livers subjected to 80 min of complete ischaemia at 37 °C. Cell yield was improved by a resuscitating perfusion from 58% to 73% and viability from 39% to 76%. 相似文献
33.
34.
Rebecca Setliff Janet E Porter Michael Malison Steve Frederick Thomas R Balderson 《JPHMP》2003,9(2):91-102
To address the need for management development in public health, the Centers for Disease Control and Prevention (CDC) established three independent workforce development initiatives aimed primarily at strengthening management and leadership capacity: the Sustainable Management Development Program, the Management Academy for Public Health, and the CDC Leadership and Management Institute. Though independently designed and implemented, the programs share similar guiding principles in their approach to management development: interactive (adult) learning, management tools that reinforce evidence-based decision making, individual feedback, continuous improvement of the learning process, posttraining support for networking and life-long learning, and teamwork. This article will discuss important lessons learned regarding best practices in management and leadership development. 相似文献
35.
Oluseun A Sowemimo Steven M Yood John Courtney Jessie Moore Miriam Huang Rebecca Ross Ursula McMillian Peter Ojo Randolph B Reinhold 《Surgery for obesity and related diseases》2007,3(1):73-7; discussion 77
BACKGROUND: To study the mortality among morbidly obese patients qualifying for bariatric surgery. Mortality from bariatric surgery for morbid obesity has been widely reported; however, little is known about the mortality in morbidly obese patients who defer surgery. METHODS: Consecutive patients evaluated for bariatric surgery with an initial encounter between 1997 and 2004 were identified. The Social Security Death Index and office records were used to identify mortality through 2006. We conducted telephone interviews to determine whether the 305 patients who did not undergo bariatric surgery at our institution had undergone the surgery elsewhere. Using Cox proportional hazards models, we compared the mortality in patients undergoing surgery with that of those who did not. To evaluate bias resulting from missing data, we conducted analyses assuming that all patients with missing data had (1) undergone surgery and (2) not undergone surgery. RESULTS: A total of 908 patients underwent bariatric surgery (880 patients at our institution and 28 patients elsewhere). A total of 112 patients did not undergo surgery. Data regarding surgery on 165 patients could not be obtained. The mortality in those patients who did not undergo surgery was 14.3% compared with 2.9% for those who did undergo surgery. Adjusting for age, gender, and body mass index, patients who had undergone surgery had an 82% reduction in mortality (hazard ratio 0.18, 95% confidence interval 0.09-0.35, P <.0001). Sensitivity analysis, assuming that all patients with missing data received surgery resulted in an 85% mortality reduction (P <.001) and assuming that patients did not receive surgery resulted in a 50% mortality reduction (P = .04). CONCLUSIONS: Mortality among morbidly obese patients without surgery was 14.3% during the study period. Surgical intervention offered a 50%-85% mortality reduction benefit. 相似文献
36.
Rebecca Lester 《Medical history》2006,50(4):559-560
37.
W Heidemann J H Fischer J Koebke C Bussmann K L Gerlach 《Mund-, Kiefer- und Gesichtschirurgie》2003,7(5):283-288
AIMS. Comparison of the degradation of poly(D,L)lactide (Resorb X) or poly(lactide-co-glycolide) (LactoSorb) in vivo. MATERIAL AND METHODS. LactoSorb and Resorb X osteosynthesis plates were fixed at the lateral aspect of the femora of 26 Chinchilla rabbits using the respective osteosynthesis screws. After intraperitoneal injection of fluorochromes the screw plate bone blocks were resected after 1, 6, 12, 14, 16, 21, 26 months and radiologic, histologic as well as fluorescence microscopic examinations were carried out. RESULTS. Newly formed bone was detectable above and beneath the polymers 1 month after the implantation. The implants were totally covered by newly formed bone after 6 months. While the LactoSorb screws were found to be as birefringent as after 1 month, in the Resorb X screws a continuous resorption by phagocytizing marrow cells starting from the periphery was detectable. Resorb X was totally resorbed in histologic slides 12 months after implantation, while total resorption of LactoSorb lasted 14 months; both polymers were replaced by marrow cells. Bone remodeling was not finished 26 months after implantation in both polymers. CONCLUSION. Resorption of Resorb X was finished earlier than the resorption of LactoSorb. Both materials were found by fluorescence microscope to be completely resorbed after 12 or 14 months, but bone remodeling of the screw holes was not yet finished 26 months after implantation. 相似文献
38.
Millicent Ford Rauch Sara Royce Hynes James Bertram y Redmond Rebecca Robinson Cicely Williams Hao Xu Joseph A. Madri Erin B. Lavik 《The European journal of neuroscience》2009,29(1):132-145
Angiogenesis precedes recovery following spinal cord injury and its extent correlates with neural regeneration, suggesting that angiogenesis may play a role in repair. An important precondition for studying the role of angiogenesis is the ability to induce it in a controlled manner. Previously, we showed that a coculture of endothelial cells (ECs) and neural progenitor cells (NPCs) promoted the formation of stable tubes in vitro and stable, functional vascular networks in vivo in a subcutaneous model. We sought to test whether a similar coculture would lead to the formation of stable functional vessels in the spinal cord following injury. We created microvascular networks in a biodegradable two-component implant system and tested the ability of the coculture or controls (lesion control, implant alone, implant + ECs or implant + NPCs) to promote angiogenesis in a rat hemisection model of spinal cord injury. The coculture implant led to a fourfold increase in functional vessels compared with the lesion control, implant alone or implant + NPCs groups and a twofold increase in functional vessels over the implant + ECs group. Furthermore, half of the vessels in the coculture implant exhibited positive staining for the endothelial barrier antigen, a marker for the formation of the blood–spinal cord barrier. No other groups have shown positive staining for the blood–spinal cord barrier in the injury epicenter. This work provides a novel method to induce angiogenesis following spinal cord injury and a foundation for studying its role in repair. 相似文献
39.
40.
Rebecca S. Howell-Jones MSc ; Patricia E. Price PhD ; Anthony J. Howard MBBS MSc FRCPath ; David W. Thomas FDRCS MScD PhD 《Wound repair and regeneration》2006,14(4):387-393
The aim of this study was to describe and quantify systemic antibiotic prescribing for patients with chronic skin wounds presenting at the primary care, nonspecialist setting. Data for 1 year were extracted from a general practice morbidity database comprising approximately 185,000 patients attending family medical practitioners in Wales. Patients with chronic wounds (PCW) were identified using Read Codes and compared with nonwound patients who were randomly selected after matching for age-band, sex, and general practice. PCW received a significantly greater number of antibiotic courses than nonwound patients (p<0.001). This increased level of prescribing was evident for flucloxacillin, co-amoxiclav, cefaclor, cefalexin, erythromycin, trimethoprim, metronidazole, and ciprofloxacin (p<0.01 for all). While PCW also had a significantly higher prevalence of diabetes (16.5% compared with 6.6%, p<0.001), and attended at general practice significantly more frequently than nonwound patients (median (interquartile range) of 25 (17-40) visits per year compared with 12 (4-20), p<0.001), importantly, exclusion of diabetic patients and analysis of the proportion of visits on which patients received antibiotics did not affect the significance of the difference in antibiotic consumption. These data show a strong association between occurrence of chronic wounds and prescribing of antibiotics in primary health care, and wide variation in the type and duration of antibiotic therapy for chronic wounds. Further work is now indicated to rationalize this prescribing and determine the role that this exposure to antibiotics plays in the prevalence of antibiotic resistance in this at-risk elderly population. 相似文献