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排序方式: 共有639条查询结果,搜索用时 46 毫秒
61.
62.
Rauh LK Horinouchi CD Loddi AM Pietrovski EF Neris R Souza-Fonseca-Guimarães F Buchi DF Biavatti MW Otuki MF Cabrini DA 《Journal of ethnopharmacology》2011,138(2):390-397
Ethnopharmacological relevance
Vernonia scorpioides (Asteraceae) is a native Brazilian medicinal plant that is commonly used to treat skin disorders. Considering the traditional use of Vernonia scorpioides and the lack of information about its pharmacological properties, we investigated the topical anti-inflammatory effect of the ethanolic extract of Vernonia scorpioides (EEVS) on acute and chronic cutaneous inflammation models in mouse.Materials and methods
The topical anti-inflammatory effect of EEVS was evaluated against acute models (12-O-tetradecanoylphorbol acetate (TPA)- and arachidonic acid (AA)-induced mouse ear oedema) and chronic models (multiple applications of croton oil).Results
The EEVS caused a dose-related inhibition of oedema in both the TPA- and AA-induced acute models (DI50 = 0.24 and 0.68 mg/ear with an inhibition of 80 ± 5% and 65 ± 5%, respectively, for 1 mg/ear). In addition, the TPA-induced increase in myeloperoxidase activity (MPO) in the ear was reduced (77 ± 8%) by the topical application of EEVS. In the chronic model, the EEVS reduced all parameters evaluated: oedema formation (31 ± 2%), epidermal hyperproliferation (histology) and MPO (25 ± 10%). However, the topical treatment of EEVS had no effect on N-acetyl-β-d-glucosaminidase activity. The EEVS effectively interfered in the ear oedema on the delayed-type hypersensitivity reaction induced by oxazolone. The topical treatment with EEVS performed on both phases or only on the elicitation phase caused the inhibition of the ear oedema-induced by oxazolone in 42.9% and 63.4%, respectively, when compared to control animals (sensitized and challenged).Conclusions
The results suggest that EEVS is effective as a topical anti-inflammatory agent in acute and chronic inflammatory processes and that its action is markedly influenced by the inhibition of neutrophil migration into inflamed tissue as well as by epidermal hyperproliferation. 相似文献63.
Kratzsch J Schubert G Pulzer F Pfaeffle R Koerner A Dietz A Rauh M Kiess W Thiery J 《Clinical biochemistry》2008,41(13):1091-1098
Objectives
The purpose of our study was to establish reference intervals for thyroid function tests in children and adolescents and to identify factors that may influence the limits of these intervals.Methods
TSH, FT3, FT4, T3, T4, t-uptake, TPO-antibody (TPO-Ab) and TG-antibody (TG-Ab) levels were determined in blood of 1004 infants, children and adolescents by the Elecsys system (Roche).Results
A distinct overall age-dependent decrease of analyte levels was found for all parameters investigated. Puberty was accompanied by an increase of TSH, FT3 and T3 levels. Results of T4 and t-uptake were significantly higher in girls compared to boys. The exclusion of children with increased TPO-Ab and TG-Ab had no significant effect on the limits of the reference interval. We found that besides age, BMI-SDS but also white blood cells count and gender played a role in the prediction of analyte variation.Conclusions
Covariates like BMI-SDS and white blood cell count should be taken into consideration when interpreting TSH and thyroid hormone measurements as well whereas gender and TPO-Ab or TG-Ab play a minor role. 相似文献64.
Bani MR Beckmann K Engel J Lux MP Rauh C Eder I Bani A HA Breuel C Bach A Beckmann MW Fasching PA 《Breast (Edinburgh, Scotland)》2008,17(6):640-645
The aim of this survey was to evaluate correlates for the patient's desire for surgical improvement of the cosmetic outcome after the primary operation for breast cancer. A cross-sectional study was carried out in a single follow-up outpatient clinic using a questionnaire. Patients were asked to assess their degree of satisfaction with the cosmetic results of their primary surgery and to state if they would like to undergo a further breast surgery to improve the appearance. Patients’ characteristics were correlated with this desire. After breast-conserving surgery, 21.6% of the patients stated that they desired surgical improvement, in comparison with 29.8% of the patients who underwent mastectomy. In the latter group, the desire for improvement remained constant up to 5 years after the initial operation, whereas it declined in the group of patients after breast-conserving surgery. Furthermore, a younger age and the perception that the appearance negatively influences femininity, partnership or sexual life were associated with a desire for further surgery. Breast reconstruction after mastectomy can be discussed with the patients even after a long follow-up, especially when the appearance seems to influence partnership issues. 相似文献
65.
Rauh MA Clark L Mutty C Anders M 《American journal of orthopedics (Belle Mead, N.J.)》2008,37(2):104-105
The occasional need to alter or modify plate length during surgery is familiar to most orthopedic surgeons. However, at the modification site, sharp edges may remain. Files or rasps are often used to smooth these edges to prevent local tissue irritation and injury to surgical personnel. To reduce the potential for personal injury during preparation and implantation, while adding convenience and speed to this procedure, we introduce a technique for filing down sharp edges of plates and implants with equipment readily available within most orthopedic operating rooms. 相似文献
66.
67.
Gudziol V Mück-Weymann M Seizinger O Rauh R Siffert W Hummel T 《The Journal of urology》2007,177(1):258-261
PURPOSE: Sildenafil is the first member of a new class of oral drugs effective for erectile dysfunction. However, approximately 20% of patients complain about nasal congestion after sildenafil administration. MATERIALS AND METHODS: Because nasal airflow and olfaction are closely linked, the sense of smell was evaluated in 20 young, healthy volunteers after the administration of 50 and 100 mg sildenafil, and placebo in a double-blinded, crossover study. Olfactory function was evaluated using a standardized and validated test (Sniffin' Sticks). To investigate a possible impact of G-protein beta3 subunit C825T polymorphism on the effect of sildenafil on olfaction the genotype of all subjects was determined. RESULTS: The effect of sildenafil on olfaction was only present at a dose of 100 mg but not at a dose of 50 mg sildenafil. The genotypes TT, CC and TC of the G-protein beta3 C825T polymorphism had no impact on the change in olfactory function. CONCLUSIONS: Higher sildenafil doses may produce decreased olfactory sensitivity. 相似文献
68.
Efferth T Kahl S Paulus K Adams M Rauh R Boechzelt H Hao X Kaina B Bauer R 《Molecular cancer therapeutics》2008,7(1):152-161
The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques. We have isolated the bioactive compounds and elucidated the chemical structures by nuclear magnetic resonance and mass spectrometry. By this strategy, we identified 25-O-acetyl-23,24-dihydro-cucurbitacin F as a cytotoxic constituent of Quisqualis indica. Another promising compound identified by this approach was miltirone from Salvia miltiorrhiza. The IC50 values for miltirone of 60 National Cancer Institute cell lines were associated with the microarray-based expression of 9,706 genes. By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone. 相似文献
69.
Bone mineral density in female high school athletes: interactions of menstrual function and type of mechanical loading 总被引:2,自引:0,他引:2
During adolescence, skeletal integrity of girls is largely dependent on menstrual function and impact exercise, yet currently there is limited research regarding the interaction between menstrual status and type of mechanical loading associated with various high school sports. Our purpose was to examine associations of menstrual status, type of mechanical loading, and bone mineral density (BMD) in female high school athletes participating in high/odd impact or repetitive/non-impact sport. Participants were 161 female high school athletes (15.7+/-1.3 years; 165.3+/-6.9 cm; 59.4+/-8.7 kg) representing high/odd impact (n=93, including soccer, softball, volleyball, tennis, lacrosse, and track sprinters and jumpers), or repetitive/non-impact sports (n=68, including swimmers, cross-country and track distance runners who participated in events>or=800 m). Areal BMD was measured by DXA at the spine (L1-L4), proximal femur, and total body. Menstrual status was determined by self-report. Athletes with primary, secondary or oligomenorrhea were combined into a single group (oligo/amenorrheic) and compared to eumenorrheic athletes. Analysis of covariance (ANCOVA) with Bonferroni post hoc comparisons adjusted for age, BMI, and gynecological age were used to compare BMD of athletes in combined mechanical loading and menstrual status groups. We found significantly greater total hip (p=0.04) and trochanter (p=0.02) BMD (g cm(-2)) among eumenorrheic high/odd impact compared to eumenorrheic repetitive/non-impact athletes, and greater spine (p=0.01) and trochanter (p=0.04) BMD among high/odd impact eumenorrheic athletes compared to repetitive/non-impact oligo/amenorrheic athletes. Chi-squared analysis of BMD Z-scores adjusted for gynecological age showed a significantly greater percentage of repetitive/non-impact athletes (33.9%) compared to high/odd impact athletes (11.8%) with low spine BMD for their age (BMD Z-score相似文献
70.
目的:为了评估在中学生运动员中女运动员三联征(进食障碍、月经失调和低骨量)的患病率。设计:观察性横断面研究。机构:中学。入选者:从南加利福尼亚的6所中学中征募的代表8项运动的女运动员(n=170)。主要观察指标:进食障碍和月经失调通过调查者协助问卷来确定。通过双能量X线吸光法测定髋部、脊椎(L1~L4)和全身的骨矿物密度。结果:在所有运动员中,有8.2%、23.5%和21.8%的运动员分别符合进食障碍、月经失调和低骨量的标准,10名女童(5.9%)符合三联中2个联征的标准,2名女童(1.2%)符合联征中所有3个联征的标准。月经过少和闭经的运动员比月经… 相似文献