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排序方式: 共有135条查询结果,搜索用时 62 毫秒
91.
Takafumi Okura Masanori Jotoku Jun Irita Daijiro Enomoto Tomoaki Nagao Veena Rasika Desilva Shiho Yamane Zuowei Pei Shiho Kojima Yasuyuki Hamano Shinichi Mashiba Mie Kurata Ken-ichi Miyoshi Jitsuo Higaki 《Clinical and experimental nephrology》2010,14(6):584-588
Background
Serum cystatin C is not only a marker of renal function but also acts as an independent risk factor for cardiovascular damage, heart failure, and death. It is known that the initiation and progression of these cardiovascular events contributes to renal dysfunction and chronic inflammation. In this study, we investigated the relationship between cystatin C and proinflammatory cytokines.Methods
Eighty-eight patients with essential hypertension participated in the study, which involved measuring proinflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and C reactive protein (CRP).Results
Positive correlations were detected between cystatin C and estimated glomerular filtration rate (eGFR) (r = ?0.503, p < 0.001), systolic blood pressure (r = ?0.246, p = 0.034), and pulse pressure (r = ?0.295, p = 0.010). In contrast, serum creatinine correlated only with eGFR (r = ?0.755, p < 0.001) and eGFR correlated only with age (r = ?0.339, p = 0.001) and not with the other clinical parameters, whereas cystatin C also correlated with log natural (ln) IL-6 (r = ?0.247, p = 0.033) and ln TNF-α (r = ?0.405, p < 0.001) but not with CRP (r = ?0.188, p = 0.108). In contrast, plasma creatinine and eGFR did not correlate with any of these proinflammatory cytokines. Stepwise regression analysis showed that ln TNF-α, eGFR and pulse pressure were independent determinants of serum cystatin C concentration.Conclusion
This study showed that cystatin C is a marker of inflammation as well as renal function. 相似文献92.
Preethi H. Gunaratne PhD Yinghong Pan PhD Abhi K. Rao PhD Chunru Lin PhD Anadulce Hernandez-Herrera PhD Ke Liang MD Antonina S. Rait PhD Avinashnarayan Venkatanarayan PhD Ashley L. Benham PhD Farwah Rubab BS Sang Soo Kim PhD Kimal Rajapakshe PhD Clara K. Chan PhD Lingegowda S. Mangala PhD Gabriel Lopez-Berestein MD Anil K. Sood MD Amy C. Rowat MD Cristian Coarfa PhD Kathleen F. Pirollo PhD Elsa R. Flores MD Esther H. Chang PhD 《Cancer》2019,125(14):2409-2422
93.
94.
Shroff GR Badve SV Joshi AG Desai DC Abraham P Sirsat RA 《Nephrology (Carlton, Vic.)》2004,9(1):44-46
Acute renal failure has rarely been reported in association with acute hepatitis A infection. The commonest form of renal injury in such patients has been found to be acute tubular necrosis. We report two cases of hepatitis A infection in which acute renal failure occurred very early in the course of the illness and had a clinical presentation and recovery pattern suggestive of acute tubular necrosis. In both patients, the clinical course of renal dysfunction was almost parallel to the course of hepatic dysfunction. Patient 1 needed dialysis, whereas patient 2 did not need dialysis and had a very rapid recovery from renal function in spite of having more severe azotaemia. Patient 2 was administered acetylcysteine in high doses for suspected fulminant hepatic failure. A potential benefit of a high dose of acetylcysteine in recovery of renal function from acute tubular necrosis is postulated. 相似文献
95.
Eddleston M Rajapakshe M Roberts D Reginald K Rezvi Sheriff MH Dissanayake W Buckley N 《Journal of toxicology. Clinical toxicology》2002,40(7):847-854
BACKGROUND: Propanil pesticide poisoning can produce methemoglobinemia, tissue hypoxia, and depression of central nervous system and respiratory system. It has been recorded only rarely worldwide and most current poison texts consider propanil to be of low toxicity. However, propanil self-poisoning is a significant clinical problem in parts of Sri Lanka and an occasional cause of death. AIM OF STUDY: To report the clinical features and management of severe propanil poisoning. PATIENTS AND METHODS: We report a retrospective case series of patients who were treated in the intensive care unit of and/or died in Anuradhapura General Hospital between 1998 and early 2002. RESULTS: Sixteen patients were identified. Common manifestations of toxicity included confusion, reduced conscious level, cyanosis, and respiratory depression. Marked hemolysis was noted in several patients. Nine deaths occurred due to respiratory depression and cardiorespiratory arrest. Management was difficult given the lack of i.v. methylene blue, inability to measure methemoglobin levels, and paucity of intensive care unit beds. CONCLUSIONS: This series indicates that propanil poisoning can be a severe form of self-poisoning, particularly in resource-poor settings. We have now initiated the establishment of a prospective series of propanil poisoned patients to further describe its clinical features, responsiveness to therapy, and case fatality rate. 相似文献
96.
This paper examines the consistency of genetic analyses across time, both in the context of replicating results from one data collection point to the next, and from the perspective of modeling longitudinal processes. This summary originates from the examination of findings from nine papers from Genetic Analysis Workshop (GAW) 13 that reported on analyses of longitudinal data of a variety of traits from the Framingham Heart Study. These analyses include both assessments of consistency of aggregate genetic effects, in the form of estimation of heritability and relative risk of disease, as well as localization of quantitative trait loci (QTLs) by genome-wide linkage screens. Consistency varied widely by trait, possibly reflecting differences in measurement error, secular trends, or underlying biological features such as genotype x age interaction. Quantitatively, comparing magnitudes of estimates across age or time, heritability estimates showed greater consistency than LOD scores. However, qualitatively, the same regions of interest were often identified in genome scans from different time points or different ages. Estimates of sibling recurrence risk, on the other hand, showed little consistency. Heritabilities were greater when participants were matched by age than when they were matched by date of examination. Multivariate approaches, either in use of multiple traits or in use of multiple measures of the same trait, appeared to provide stronger genetic signals both for relative risk and for linkage. Finally, modeling of longitudinal processes provided evidence for genotype x age interactions that may partially explain variation in results of genetic analyses across time or age. 相似文献
97.
98.
99.
Jing?Zhang Rohina?Joshi Jixin?Sun Samantha?R.?Rosenthal Miao?Tong Cong?Li Rasika?Rampatige Meghan?Mooney Alan?Lopez Lijing?L.?YanEmail author 《Population health metrics》2016,14(1):31
Background
Currently there are two main sources of mortality data with cause of death assignments in China. Both sources–the Ministry of Health-Vital Registration system and the Chinese Disease Surveillance Point system–present their own challenges. A new approach to cause of death assignment is a smartphone-based shortened version of a verbal autopsy survey. This study evaluates the feasibility and acceptability of this new method conducted by township health care providers (THP) and village doctors (VD) in rural China, where a large proportion of deaths occur in homes and cause of death data are inaccurate or lacking.Methods
The Population Health Metrics Research Consortium mobile phone-based shortened verbal autopsy questionnaire was made available on an Android system-based application, and cause of death was derived using the Tariff method (Tariff 2.0); we called this set of tools “msVA.” msVA was administered to relatives of the deceased by six THPs and six VDs in 24 villages located in six townships of Luquan County, Hebei Province, China. Subsequently, interviews were conducted among 12 interviewers, 12 randomly selected respondents, and five study staff to assess the feasibility and acceptability of using msVA for mortality data collection.Results
Between July 2013 and August 2013, 268 deaths took place in the study villages. Among the 268 deaths, 227 VAs were completed (nine refusals, 31 migrations and one loss of data due to breakdown of the smartphone). The average time for a VA interview was 21.5?±?3.4 min (20.1?±?3.5 min for THP and 23.2?±?4.1 min for VD). Both THPs and VDs could be successful interviewers; the latter needed more training but had more willingness to implement msVA in the future. The interviews revealed that both interviewers and relatives of the deceased found msVA to be feasible, acceptable, and more desirable than traditional methods. The cost of conducting a new VA was $8.87 per death.Conclusions
Conduction of msVA by VDs in their own villages was feasible and acceptable in rural northern China. Broader implementation of msVA across rural China could potentially improve the coverage and quality of cause of death data, allowing for better national health evaluation and program planning.100.
Huang JL Gao PS Mathias RA Yao TC Chen LC Kuo ML Hsu SC Plunkett B Togias A Barnes KC Stellato C Beaty TH Huang SK 《Human molecular genetics》2004,13(21):2691-2697