全文获取类型
收费全文 | 3770篇 |
免费 | 279篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 145篇 |
妇产科学 | 105篇 |
基础医学 | 431篇 |
口腔科学 | 98篇 |
临床医学 | 372篇 |
内科学 | 902篇 |
皮肤病学 | 99篇 |
神经病学 | 204篇 |
特种医学 | 199篇 |
外科学 | 434篇 |
综合类 | 153篇 |
一般理论 | 5篇 |
预防医学 | 239篇 |
眼科学 | 81篇 |
药学 | 314篇 |
1篇 | |
中国医学 | 14篇 |
肿瘤学 | 249篇 |
出版年
2023年 | 31篇 |
2022年 | 74篇 |
2021年 | 164篇 |
2020年 | 88篇 |
2019年 | 139篇 |
2018年 | 186篇 |
2017年 | 91篇 |
2016年 | 115篇 |
2015年 | 109篇 |
2014年 | 156篇 |
2013年 | 219篇 |
2012年 | 282篇 |
2011年 | 218篇 |
2010年 | 161篇 |
2009年 | 144篇 |
2008年 | 182篇 |
2007年 | 205篇 |
2006年 | 214篇 |
2005年 | 156篇 |
2004年 | 143篇 |
2003年 | 118篇 |
2002年 | 89篇 |
2001年 | 41篇 |
2000年 | 38篇 |
1999年 | 32篇 |
1998年 | 44篇 |
1997年 | 65篇 |
1996年 | 57篇 |
1995年 | 37篇 |
1994年 | 41篇 |
1993年 | 44篇 |
1992年 | 38篇 |
1991年 | 23篇 |
1990年 | 28篇 |
1989年 | 21篇 |
1988年 | 30篇 |
1987年 | 22篇 |
1986年 | 21篇 |
1985年 | 23篇 |
1984年 | 15篇 |
1983年 | 18篇 |
1982年 | 18篇 |
1981年 | 24篇 |
1980年 | 15篇 |
1979年 | 11篇 |
1978年 | 8篇 |
1977年 | 8篇 |
1976年 | 18篇 |
1975年 | 9篇 |
1973年 | 9篇 |
排序方式: 共有4066条查询结果,搜索用时 15 毫秒
11.
De Leo V; Morgante G; Lanzetta D; D'Antona D; Bertieri RS 《Human reproduction (Oxford, England)》1997,12(2):357-360
We report the results of administration of danazol after suspension of
gonadotrophin-releasing hormone analogue (GnRHa) therapy for uterine
myomas. A total of 21 women with uterine myomas was treated with 100 mg
danazol for 6 months after GnRHa therapy. Uterine volume and endocrine
status were monitored monthly by ultrasound and assay of plasma
gonadotrophins, oestradiol and progesterone. The results show a rebound of
uterine volume about 30% less than in controls at the end of danazol
therapy. Menstrual cyclicity returned after 65 +/- 3 days in 16 subjects
and five patients remained amenorrhoeic. Hormone assays confirmed renewed
ovarian function in the women whose menstrual periods returned. Bone
mineral content was substantially reduced during GnRHa treatment but
improved significantly during danazol therapy even in the women who
remained amenorrhoeic. These results show the utility of danazol in
prolonging the therapeutic effects of GnRHa. The mechanism by which danazol
inhibits rebound of uterine volume may be due to its antiprogesterone
effects on uterine myomas.
相似文献
12.
R C Young C P Downes D S Eggleston M Jones C H Macphee K K Rana J G Ward 《Journal of medicinal chemistry》1990,33(2):641-646
A new and convenient method for the preparation of the four stereoisomers of dihexadecanoyl phosphatidylinositol has been developed. An enantiomeric pair of acid-labile, pentaprotected myo-inositol building blocks was synthesized in high yield and coupled with chiral phenyl dihexadecanoylglyceryl phosphates to give the fully protected phosphatidylinositols. These were subsequently deprotected by hydrogenolysis and self-hydrolysis in aqueous ethanol to give the desired pure products. Comparison of these compounds as potential substrates for a partially purified phosphatidylinositol 4-kinase (EC 2.7.1.67) derived from human erythrocyte membranes revealed that the chirality of the inositol ring is crucial for efficient phosphorylation, whereas the chirality of the glycerol moiety is relatively unimportant. Moreover, the similarity in phosphorylation rates of the naturally occurring mammalian phospholipid, I, and its synthetic stereochemical counterpart, compound 10a, suggests that the enzyme is relatively tolerant to changes in fatty acid composition. 相似文献
13.
Narendra Nathoo Sameer S Nadvi Duncan Royston Mahesh Rana Premjith Gathiram Pratistadevi K Ramdial James R van Dellen 《Journal of clinical neuroscience》2004,11(1):61-65
Patients with acute brain pathology requiring ferromagnetic bio-medical implants for on-going invasive monitoring are largely excluded from the benefits of MRI scanning. We evaluated the behaviour of a thermal diffusion cortical blood flow (TD-CBF) sensor both in vitro (phantom gelatin model) and in vivo environments in a high field strength MRI system.Two baboons underwent cranial subdural implantation of 2 TD-CBF sensors/hemisphere and a single left parietal sensor was implanted subcortically to determine any deleterious effects. Using standard MRI sequences, artefact size, thermal effects, current generation, movement and reliability of recordings were assessed during scanning.The deflection forces were negligible, no observable thermal effects were demonstrated, while wide fluctuations in cerebral blood flow recordings were recorded. Mean image artefact size for implanted sensors was 6 times larger than in vitro. Patients with an implanted TD-CBF sensor may be safely imaged provided the device is disconnected. The MRI images obtained are of an acceptable quality. 相似文献
14.
15.
16.
17.
18.
Prior studies have shown that pneumothorax is one of the more difficult entities to diagnose with digitized radiography. This study was designed to test whether increasing resolution from 1.25 to 2.5 line pairs per millimeter (lp/mm) and image processing (edge enhancement from unsharp masking) would increase accuracy and confidence in the diagnosis of pneumothorax, as well as normal cases and other forms of lung disease. Conventional radiographs were digitized with use of a laser reader and then reformatted as film hard copy. Eleven observers read 35 cases reformatted in three different ways (1.25 lp/mm, 2.5 lp/mm, 1.25 lp/mm unsharp mask). The images with finer resolution (2.5 lp/mm) and unsharp mask images were superior to those with coarser resolution (1.25 lp/mm) for the diagnosis of pneumothorax. There was no difference in diagnostic accuracy for normal patients. For abnormalities other than pneumothorax, the unsharp mask images were significantly worse. Confidence in the diagnosis of pneumothorax and other abnormalities was highest with the finest resolution (2.5 lp/mm). 相似文献
19.
The authors report the clinical and laboratory findings of a patient who had severe immune hemolytic anemia due to hydrochlorothiazide (HCTZ). In this case, the HCTZ antibody reacted not only with other thiazide and thiazide-like drugs, but also with a chemically unrelated diuretic, ethacrynic acid. These results indicate that HCTZ antibody activity is not restricted solely to the thiazides and imply that therapy with any of the reactive drugs would be contraindicated for this patient. The serologic screening for drug reactivity may be useful for selecting alternative therapy for patients with drug-induced immune hemolytic anemia. 相似文献
20.
Relationship of knee joint proprioception to pain and disability in individuals with knee osteoarthritis. 总被引:7,自引:0,他引:7
Kim L Bennell Rana S Hinman Ben R Metcalf Kay M Crossley Rachelle Buchbinder Michael Smith Geoffrey McColl 《Journal of orthopaedic research》2003,21(5):792-797
Proprioception plays an integral role in neuromotor control of the knee joint and deficits in knee joint proprioception are well documented in individuals with knee osteoarthritis (OA). However, the functional relevance of these deficits is not clear. This cross-sectional study evaluated the relationship between knee joint proprioception and pain and disability in a large cohort of individuals with knee OA. Two hundred and twenty participants (145 F, 75 M) with symptomatic knee OA were recruited from the community. Five non-weight bearing active tests with ipsilateral limb matching responses were performed at 20 degrees and 40 degrees flexion to measure knee joint position sense. Pain and disability were assessed by self-reported questionnaires and objective measures of balance and gait. Results showed little association between knee joint position sense variables and measures of pain and disability (r values <0.24, most p>0.05). When comparing participants with the worst and best joint position sense, no significant differences in pain and disability could be found (p>0.05). While our study design does not allow causality to be established, these results suggest that deficits in joint position sense may be due to factors other than pain and that deficits are not large enough to impact upon disability. 相似文献