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131.
A modified, sensitive, solid-phase assay for platelet-associated IgG is reported. Direct comparisons were made between a 125I monoclonal radioimmunoassay (RIA) and the polyclonal antibody latex particle assay. In 209 simultaneous comparisons with the RIA, the sensitivity of the latex test was 91 percent, specificity was 100 percent, and overall efficiency was 97 percent. Commencing with platelet-rich plasma, the direct latex particle test for platelet-bound IgG requires 45 minutes; 90 minutes are required to crossmatch one patient with 12 donors. The advantages of the latex assay are absence of radioactivity, stability of reagents, economy, speed, specificity, and sensitivity. 相似文献
132.
133.
Uterine carcinoma in mice treated neonatally with tamoxifen 总被引:11,自引:6,他引:5
The induction of preneoplastic and neoplastic lesions by the widely used
antiestrogen Tamoxifen was studied in female mice. Outbred CD-1 mice were
treated with Tamoxifen (1, 2, 5, 10, 25 or 50 microg/pup/day) for the first
5 days after birth. At 14-17 months, reproductive tract tissues were
examined for pathological changes. In the ovary, corpora lutea were lacking
while cysts were quite common in Tamoxifen-exposed mice at all doses;
cystadenomas were seen in two mice. Structural malformations and epithelial
hyperplasia of the oviduct were seen in 100% of the treated mice.
Malformations of the uterus, cervix, and vagina were also seen. Excessive
vaginal keratinization was not a common feature although vaginal adenosis
was observed more often after Tamoxifen treatment than previously reported
after similar treatment with diethylstilbestrol (DES). The most striking
histological features, however, were seen in the uterus. One hundred
percent of the Tamoxifen- treated mice at all doses exhibited uterine
hypoplasia with focal areas of basal cell hyperplasia in the lining
endometrium. Progressive cellular atypias were seen in the lining
endometrium ranging from atypical hyperplasia to uterine adenocarcinoma;
the highest incidence of uterine adenocarcinoma was 7/14 (50%) observed in
the Tamoxifen 10 microg/pup/day dose group. No similar tumors were observed
in corresponding control mice. The induction of atypical uterine
hyperplasia and adenocarcinoma combined with other abnormalities observed
in genital tract structure following neonatal treatment with Tamoxifen
suggests the developing reproductive tract is exquisitely sensitive to
perturbation by compounds with hormonal activity. These studies provide the
basis for future investigation into the mechanisms of Tamoxifen's
carcinogenic effects in experimental animals, and to the risk benefit
analysis for the prophylactic use of Tamoxifen in healthy women who are at
risk of developing breast cancer.
相似文献
134.
135.
136.
Acute appendicitis: sonographic criteria based on 250 cases 总被引:16,自引:1,他引:15
Two hundred and fifty consecutive patients with suspected appendicitis were examined with graded compression sonography. The initial diagnostic criterion for appendicitis was visualization of a noncompressible appendix; this was later modified to include the dimensions of the visualized appendix. The appendix was visualized in 91 of 250 patients (36%). Five adult patients with sonographically visible appendixes that were 6 mm or less in maximal diameter had either benign clinical follow-up (three patients) or a histologically normal appendix removed at surgery (two patients). However, two patients with appendixes measuring 6 mm in diameter and multiple appendicoliths had surgically confirmed acute appendicitis. Of 84 patients with visible appendixes measuring greater than 6 mm in maximal diameter, 78 had surgically confirmed acute appendicitis. In the remaining six, symptoms resolved spontaneously, and no surgery was required. In the absence of compelling clinical findings or an appendicolith, adult patients with maximal appendiceal diameters of 6 mm or less should undergo a period of close observation rather than immediate surgery. A diagnosis of appendicitis can be made in adult patients with persistent right lower quadrant pain and a visualized appendix greater than 6 mm in diameter. 相似文献
137.
Pancreatic pseudocysts drained through a percutaneous transgastric approach: further experience 总被引:3,自引:0,他引:3
Percutaneous transgastric placement of a drainage catheter under ultrasonographic and fluoroscopic guidance was performed in 12 patients with pancreatic pseudocysts. Complete resolution of the pseudocysts was obtained in eight patients, and the result was indeterminate in one patient due to early death from unrelated causes. Surgical intervention followed in two patients, one with a multiloculated pseudocyst that was incompletely drained and another with a pseudocyst that became infected following drainage. In one patient with metastatic tumor to the head of the pancreas the pseudocyst resolved initially, but a pseudocyst later recurred. There were no pancreaticocutaneous fistulas or other major complications. The transgastric route of pseudocyst drainage is safe and effective, and it offers a low risk of recurrence and fistula formation. 相似文献
138.
139.
Gastrohepatic ligament: normal and pathologic CT anatomy 总被引:8,自引:0,他引:8
140.
In vitro radiosensitivity of human leukemia cell lines 总被引:1,自引:0,他引:1
Weichselbaum RR; Greenberger JS; Schmidt A; Karpas A; Moloney WC; Little JB 《Radiology》1981,139(2):485