非增强门静脉磁共振成像技术研究

目的 通过使用不同成像序列及接收线圈,寻找最佳非增强门脉磁共振成像技术。方法 对２０例上腹部受检者行门静脉成像。以轴位为定位像,行冠状位扫描。其中１０例ＧＲＡＳＳ、ＧＲＡＳＳ＋ＥＡＴＳＡＴ、ＳＰＧＲ、ＳＰＧＲ＋ＦＡＴＳＡＴ４种序列扫描;１０例以体线圈、ＧＰＦ线圈及胸腰椎线圈和ＧＲＡＳＳ扫描。所得图像均进行ＭＩＰ重建,并对ＭＩＰ重建图像门静脉显示效果进行对比评价。结果 ＳＰＧＲ,ＧＲＡＳＳ信噪比、对     

2型糖尿病及其血管并发症患者血清ACE活性的变化

This investigation was made with reference to the changes of serum angiotensin converting enzyme (SACE) activity in type 2 diabetes and its vascular complications. SACE activity was studied in 127 type 2 diabetic patients and 90 healthy persons by using a spectrophotometric assay. The results showed SACE activity was obviously higher in diabetic patients (459.51 +/- 175.85 U) than in healthy persons (321.14 +/- 121.27 U); SACE activity was significantly higher in type 2 diabetic patients with diabetic nephropathy (548.27 +/- 166.60 U) than in patients without diabetic nephropathy (383.2 +/- 139.00 U), but there was no difference between patients with microalbuminuria and macroalbuminuria; no statistical difference was detected in SACE activity between diabetic patients with diabetic retinopathy (465.64 +/- 178.93 U) and without retinopathy (449.07 +/- 170.04 U); SACE activity was not associated with the course of diabetes, blood pressure, blood lipid and blood glucose. These data suggest that raised SACE activity might only play a role in the initiation of type 2 diabetes and diabetic nephropathy, but not relate to the progress of diabetic nephropathy, the onset of diabetic retinopathy and hypertension.     

肝素对脂多糖诱导人肾小球系膜细胞增殖及细胞分泌物影响

为了解肝素对脂多糖诱导人肾小球系膜细胞增殖和细胞因子分泌的影响。作者采用四甲基偶氮唑蓝比色分析法及生物活性法,分别测定了人肾小球ＭＣ增殖和细胞因子的分泌情况。结果显示;在正常培养条件下,人肾上球ＭＣ分泌一定理的白细胞介素６（ＩＬ－６０和肿瘤坏死因子α（ＴＮＦ－α）。脂多糖诱导ＭＣ增殖及分泌ＩＬ－６,ＴＮＦ－α。高浓度的肝素（５００Ｕ／ｍｌ）促进ＭＣ增殖及分泌细胞因子,低浓度的肝素（５Ｕ／ｍｌ）抑制     

Urban-rural comparison of HBV and HCV infection prevalence in eastern China

The present study was initiated to make and urban-rural comparison of the prevalence of cases positive to hepatitis B and C virus(HBV and HCV,respectively)infection markers in densely populated eastern half of China.For this purpose.10 survey sites were selected,i.e.,six sites in urban areas(the city group;Beijing,shangahi and four provincial capitals)and four sites in rural areas(the village group;one village each in Jilin and Shandong provinces,and two villages in Shaanxi Province),About 50 adult women per site volunteered to participate,from whom 494 valid bllod samples were collected.Positivities to HBsAg(HBsAg^ ),anti-HBs(anti-HBs^ )and antiHBc(anti-HBc^ )were examined by RIA methods.and that to anti-HCV(anti-HCV^ )by either EIA or RIA.Those positive to any one of the three HBV infection markers were taken as HBV infection-positive(HBV^ ).The prevalence of HBsAg^ ,HBV^ and anti-HBc^ was 8%,70%and 2.7% in the city group,and 8%,65% and 2.0%in the village group,and no significant difference was found between the two groups.The overall prevalence was 8% for HBsAg^ ,68% for HBV^ ,and 2.4% for anti-HVC^ ,The results were discussed in reference to some 20 papers each on HBV^ and anti-HCV^ prevalence in China published since(1991),The reviewing of these papers of anti-HCV was low(well below 5%),and that no substantial difference was found between the rural and urban populations.     

P_(16)蛋白在卵巢上皮性肿瘤的表达及临床意义

目的 :探讨P16蛋白在卵巢上皮性肿瘤中的表达及临床意义。方法 :采用SP免疫组化法检测P16蛋白在 82例卵巢上皮性肿瘤组织 (良性 2 0例 ,恶性癌 6 2例 )及 1 5例正常卵巢组织常规石蜡标本的表达。结果 :P16蛋白在卵巢上皮性癌中检出率为 5 3 2 % ,低于良性卵巢瘤 90 0 %及正常组织 93 3% (P <0 0 1 )。不同分化程度卵巢癌之间P16蛋白的阳性率无显著差别 (P >0 0 5 ) ,P16蛋白表达与临床分期及预后有关 (P <0 0 5 ,P <0 0 1 )。结论 :P16蛋白在卵巢上皮性恶性肿瘤的发生、发展中起作用 ,P16的缺失表达与卵巢癌的进展和预后不良有关。     

小学生学习困难综合干预前瞻性研究

目的 验证综合干预治疗小学生学习困难（ＬＤ）的效果。方法 ８４例ＬＤ学生分成干预组（４３例）和不干预组（４１例）作对照,用教育、家庭、学校干预和心理治疗及药物治疗进行综合干预。结果 二年后,干预组有效率（７６．７４％）、学习成绩及智商明显高于不干预组,ＬＤ和行为问题发生率明显低于后者（Ｐ〈０．０５～０．０１）。结论 综合干预是通过增强学生学习自信心,减少或消除心理行为问题,提高智力水平等综合发挥效     

支气管肺炎患儿血清IL-6水平变化及临床意义

采用放免法检测了42例支气管肺炎和25例对照组小儿血清白细胞介素-6(IL-6)水平,结果显示肺炎患儿血清IL-6水平较对照组显著升高(P<0.01);重症肺炎与轻症肺炎患儿血清IL-6水平相比较有显著差异(P<0.001),病情越重,其水平也越高;IL-6水平与末梢血白细胞总数升高程度有一定相关,呈正比例关系。提示IL-6是反映肺炎感染严重程度的良好指标。     

新型国产人工颈椎间盘置换对山羊邻近节段影响的实验研究

目的 比较新型国产人工颈椎间盘置换与颈椎前路减压植骨融合内固定术对山羊施术节段邻近颈椎间盘退变的影响。方法 12只实验山羊随机分为3组,每组4只：间盘组（CDR组）行C_3/4间盘摘除、新型国产人工颈椎间盘植入术;融合组（ACDF组）行C_3/4间盘摘除、植骨融合内固定术;对照组不进行手术。分别于术后1、3个月行颈椎正侧位X线检查,根据改良Kellgren评分法及椎间盘相对高度测量（RDH）法进行评价。结果 动物实验中所有山羊均成活,无切口感染及肢体瘫痪。间盘组与对照组在术后1个月与3个月Kellgren评分比较,差异无统计学意义（P＞0.05）;术后1个月与术后3个月融合组Kellgren评分高于间盘组,且差异有统计学意义（P＜0.05）。三组术前的RDH比较差异无统计学意义,术后1个月及3个月融合组的RDH均低于间盘组、对照组,且与两组比较差异均有统计学意义（P＜0.05）,间盘组与对照组术后RDH比较差异无统计学意义（P＞0.05）。结论 新型国产人工颈椎间盘置换可以有效防止山羊颈椎手术邻近节段的退变。     

Effects of intraperitoneal Ringer's lactate instillation and infusion on postsurgical adhesion formation

We compared the effects of continuous Ringer's lactate infusion and Ringer's lactate instillation on postsurgical adhesion formation in the rat model. The results show that intraperitoneal Ringer's lactate instillation reduces postsurgical adhesions. However, its efficacy is not improved by additional infusion of Ringer's lactate.     

心脏瓣膜替换术体外循环搏动性血流灌注临床应用研究

本文报道心脏瓣膜病二尖瓣替换或二尖瓣加主动脉瓣双瓣膜替换术６５例,用双盲法选择病例,其中体外循环搏动性血流灌注３３例,平流灌注３２例,两组比较：搏动组心脏自动复跳率明显提高,术中尿量明显增加,术后用呼吸机时间明显缩短,差异有极显著性（Ｐ＜００１）,肢体末梢皮肤温度恢复时间提前,应用心肌正性肌力药例数,时间明显减少,两组差异明显（Ｐ＜００５）,血红蛋白尿例数有所增高,血小板计数（ＰＣ）及术后引流量差异无显著性（Ｐ＞００５）,随搏动时间的延长,血浆游离血红蛋白呈进行性增高,平均每３０ｍｉｎ增高６ｍｇ,差异有非常显著性（Ｐ＜００１）。研究证明搏动性血流灌注明显优于平流灌注。