OBJECTIVES: To assess the effect of pain-free treadmill training on red blood cell deformability and walking distance in patients with claudication. DESIGN: Randomized-controlled trial of exercise training. SETTING: Patients were recruited from the primary care, vascular outpatient clinic. PATIENTS: A total of 60 patients with peripheral arterial occlusive disease (stage II according to Leriche-Fontaine) were randomized into the treadmill program or a control group. Fifty-five patients completed the study (27 in the exercising group and 28 in the control group). INTERVENTIONS: Patients in the exercising group were walking on the treadmill 3 times a week for 3 months. Each session consisted of 1 hour repetitive walking [performed to 85% of the pain-free walking time (PFWT)] was supervised by a qualified physiotherapist. MAIN OUTCOME MEASUREMENTS: Changes in erythrocyte deformability and treadmill walking performance (PFWT, maximal walking time) were assessed in both groups before the study and after 3 months. RESULTS: After 3 months of treadmill training, red blood cell deformability in the exercising group significantly increased (P<0.01). No significant changes were seen in the erythrocyte deformability in the control group. PFWT was prolonged by 102% from 191+/-34 to 386+/-60 seconds (P<0.01), and maximal walking time increased by 49% from 438+/-62 to 656+/-79 seconds (P<0.01) in the exercising group, whereas these changes were insignificant in the control group. CONCLUSIONS: A significant improvement of walking ability over 3 months of pain-free treadmill training is associated with a significant increase in red cell deformability in patients with claudication. 相似文献
Background: This study evaluated the ability of dexmedetomidine to provide analgesia and sedation for outpatient colonoscopy, examining outcomes including cardiorespiratory variables, side effects, and discharge readiness.
Methods: Sixty-four patients were randomly assigned to one of three treatment regimens. In group D, patients received 1 [mu]g/kg dexmedetomidine over 15 min followed by an infusion of 0.2 [mu]g [middle dot] kg-1 [middle dot] h-1. Group P received meperidine (1 mg/kg) with midazolam (0.05 mg/kg), and group F received fentanyl (0.1-0.2 mg intravenous) on demand. The assessment included measurements of heart rate, blood pressure, oxygen saturation, respiratory rate, quality of sedation/analgesia, and an evaluation of the recovery time.
Results: The study was terminated before the planned 90 patients had been recruited because of adverse events in group D. In all groups, negligible hemoglobin oxygen saturation and respiratory rate variations were observed. In group D, there was a significantly larger decrease in heart rate (to approximately 40 beats/min in 2 of 19 cases) and blood pressure (to less than 50% of the initial value in 4 of 19 patients). Supplemental fentanyl was required in 47% of patients receiving dexmedetomidine to achieve a satisfactory level of analgesia (vs. 42.8% of patients in group P and 79.2% of patients in group F). Vertigo (5 patients), nausea/vomiting (5 patients), and ventricular bigeminy (1 patient) were observed only in group D. Time to home readiness was longest in group D (85 +/- 74, 39 +/- 21, and 32 +/- 13 min in groups D, P and F, respectively; P = 0.007). 相似文献
It is well known that physicians' night-call duty may cause impaired performance and adverse effects on subjective health,
but there is limited knowledge about effects on sleep duration and recovery time. In recent years occupational stress and
impaired well-being among anaesthesiologists have been frequently reported for in the scientific literature. Given their main
focus on handling patients with life-threatening conditions, when on call, one might expect sleep and recovery to be negatively
affected by work, especially in this specialist group. The aim of the present study was to examine whether a 16-hour night-call
schedule allowed for sufficient recovery in anaesthesiologists compared with other physician specialists handling less life-threatening
conditions, when on call. 相似文献
Past studies of associations between measures of the built environment, particularly street connectivity, and active transportation
(AT) or leisure walking/bicycling have largely failed to account for spatial autocorrelation of connectivity variables and
have seldom examined both the propensity for AT and its duration in a coherent fashion. Such efforts could improve our understanding
of the spatial and behavioral aspects of AT. We analyzed spatially identified data from Los Angeles and San Diego Counties
collected as part of the 2001 California Health Interview Survey. 相似文献
To test the effects of the use of a collapsible, portable chair (chair B), as opposed to a ‘standard’ chair (chair A), on
the outcome of the timed “Up and Go” (TUG) test. 相似文献
Exercise has been recommended for improving global-well being in adults with fibromyalgia. However, no meta-analysis has determined
the effects of exercise on global well-being using a single instrument and when analyzed separately according to intention-to-treat
and per-protocol analyses. The purpose of this study was to fill that gap. 相似文献
Due to marginalization, trafficking violence, conflicts with the police and organic and social psychological problems associated
with the drug, crack is one of the most devastating drugs currently in use. However, there is evidence that some users manage
to stay alive and active while using crack cocaine for many years, despite the numerous adversities and risks involved with
this behavior. In this context, the aim of the present study was to identify the strategies and tactics developed by crack
users to deal with the risks associated with the culture of use by examining the survival strategies employed by long-term
users. 相似文献
Malaria, caused by the parasite Plasmodium falciparum, is a significant source of morbidity and mortality in southern Zambia. In the Mapanza Chiefdom, where transmission is seasonal,
Anopheles arabiensis is the dominant malaria vector. The ability to predict larval habitats can help focus control measures. 相似文献