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排序方式: 共有223条查询结果,搜索用时 31 毫秒
81.
金艾康合并化学药物治疗肿瘤临床疗效观察 总被引:4,自引:2,他引:2
目的:探讨金艾康(汉防己甲素片)合用化学药物治疗肿瘤的临床增效作用。方法:通过比较治疗组与对照组(金艾康合并化学药物者为治疗组,单用化学药物者为对照组,每组各为30例)的总缓解率与毒副反应来评价金艾康对化疗药物的增效作用。结果:治疗组与对照组的总缓解率分别为80%与66.7%,其中部分毒副反应如消化道反应与肢端订木症状等治疗组明显低于对照组。结论:金艾康具有对化学药物治疗肿瘤增效作用,其作用机理可 相似文献
82.
Seventeen cases of an aberrant sheet of tissue in the amniotic cavity are described to expand and clarify previous observations of this entity. The sheet of tissue demonstrates a thickened base and a free edge that undulates. The fetus moves freely about the sheet of tissue. There are no associated fetal deformities, and infants have no manifestations of the amniotic-band syndrome. Evidence suggests that these sheets may originate from "wrapping" of the amniochorionic membrane over a uterine synechia. These benign sheets of tissue should not be confused with the amniotic-band syndrome. 相似文献
83.
Cystic retroperitoneal lymphangioma in infants and children 总被引:2,自引:0,他引:2
84.
Obstetrical magnetic resonance imaging: maternal anatomy 总被引:4,自引:1,他引:3
Eleven patients whose pregnancies were at 34-36 weeks of gestational development underwent magnetic resonance (MR) imaging. Images of the maternal pelvis were assessed for anatomical changes of pregnancy in comparison with MR images of five non-pregnant volunteers. The relationship of the fetal presenting part to the internal os of the cervix was seen in all patients. Effacement of the cervix was identified when present. The maternal spine demonstrated disk abnormalities in nine patients. Changes in venous flow patterns were readily identified in all patients. The inferior vena cava was flattened or obliterated, a high signal was present in the iliac vessels (TE 56), and large collateral vessels were present. 相似文献
85.
86.
Initiation of growth of baboon primordial follicles in vitro 总被引:5,自引:2,他引:5
Wandji SA; Srsen V; Nathanielsz PW; Eppig JJ; Fortune JE 《Human reproduction (Oxford, England)》1997,12(9):1993-2001
Factors that cause some primordial follicles to enter the growth phase
while the others remain quiescent are unknown. The hypothesis was tested
that primate primordial follicles can survive and initiate growth in vitro
in serum-free medium. Superficial pieces of ovarian cortex, containing
mostly primordial follicles, were obtained from baboon fetuses during late
gestation and cultured for 0, 2, 4, 7, 10 or 20 days in Waymouth MB 752/1
medium supplemented with insulin, transferrin, selenium, linoleic acid, and
bovine serum albumin (ITS +). Histological examination of cortical pieces
revealed that after 2 and 4 days in culture, the total number of primordial
follicles had decreased by 55 and 76% (P < 0.01) respectively, relative
to day 0 of culture. This was associated with a sustained, 5- to 8-fold
increase in total primary follicles (P < 0.01) beginning on day 2 of
culture. There was also a gradual increase in the total number of early
secondary and secondary follicles. The average diameter of follicles and
oocytes increased gradually throughout culture for all follicular
categories (P < 0.01), except secondary follicles and oocytes.
Immunohistochemical localization of proliferating cell nuclear antigen
(PCNA), a marker for cell proliferation and growth, showed that PCNA was
generally absent in primordial follicles on day 0, but was observed after 2
or 4 days in culture in both granulosa cells and oocytes of most growing
follicles. Comparison of cortical pieces cultured for 10 or 20 days with
ITS + versus 10% fetal bovine serum (FBS) showed a more pronounced decrease
in the numbers of primordial follicles and more primary, early secondary
and secondary follicles in ITS + compared to FBS-treated cortical pieces (P
< 0.01 at 20 days). These results show that primordial follicles from
non-human primates can survive and develop to the secondary stage in vitro
in serum-free conditions.
相似文献
87.
88.
Daniel S Martin Maryam Khosravi Mike PW Grocott Michael G Mythen 《Critical care (London, England)》2010,14(4):315
The human fetus develops in a profoundly hypoxic environment. Thus, the foundations of our physiology are built in the most
hypoxic conditions that we are ever likely to experience: the womb. This magnitude of exposure to hypoxia in utero is rarely experienced in adult life, with few exceptions, including severe pathophysiology in critical illness and environmental
hypobaric hypoxia at high altitude. Indeed, the lowest recorded levels of arterial oxygen in adult humans are similar to those
of a fetus and were recorded just below the highest attainable elevation on the Earth's surface: the summit of Mount Everest.
We propose that the hypoxic intrauterine environment exerts a profound effect on human tolerance to hypoxia. Cellular mechanisms
that facilitate fetal well-being may be amenable to manipulation in adults to promote survival advantage in severe hypoxemic
stress. Many of these mechanisms act to modify the process of oxygen consumption rather than oxygen delivery in order to maintain
adequate tissue oxygenation. The successful activation of such processes may provide a new chapter in the clinical management
of hypoxemia. Thus, strategies employed to endure the relative hypoxia in utero may provide insights for the management of severe hypoxemia in adult life and ventures to high altitude may yield clues to
the means by which to investigate those strategies. 相似文献
89.
90.
Ahilanandan Dushianthan Rebecca Cusack Victoria Goss Anthony D Postle Mike PW Grocott 《Critical care (London, England)》2012,16(6):1-11
Acute lung injury and acute respiratory distress syndrome (ARDS) are characterised by severe hypoxemic respiratory failure and poor lung compliance. Despite advances in clinical management, morbidity and mortality remains high. Supportive measures including protective lung ventilation confer a survival advantage in patients with ARDS, but management is otherwise limited by the lack of effective pharmacological therapies. Surfactant dysfunction with quantitative and qualitative abnormalities of both phospholipids and proteins are characteristic of patients with ARDS. Exogenous surfactant replacement in animal models of ARDS and neonatal respiratory distress syndrome shows consistent improvements in gas exchange and survival. However, whilst some adult studies have shown improved oxygenation, no survival benefit has been demonstrated to date. This lack of clinical efficacy may be related to disease heterogeneity (where treatment responders may be obscured by nonresponders), limited understanding of surfactant biology in patients or an absence of therapeutic effect in this population. Crucially, the mechanism of lung injury in neonates is different from that in ARDS: surfactant inhibition by plasma constituents is a typical feature of ARDS, whereas the primary pathology in neonates is the deficiency of surfactant material due to reduced synthesis. Absence of phenotypic characterisation of patients, the lack of an ideal natural surfactant material with adequate surfactant proteins, coupled with uncertainty about optimal timing, dosing and delivery method are some of the limitations of published surfactant replacement clinical trials. Recent advances in stable isotope labelling of surfactant phospholipids coupled with analytical methods using electrospray ionisation mass spectrometry enable highly specific molecular assessment of phospholipid subclasses and synthetic rates that can be utilised for phenotypic characterisation and individualisation of exogenous surfactant replacement therapy. Exploring the clinical benefit of such an approach should be a priority for future ARDS research. 相似文献