全文获取类型
收费全文 | 11931篇 |
免费 | 585篇 |
国内免费 | 99篇 |
专业分类
耳鼻咽喉 | 66篇 |
儿科学 | 293篇 |
妇产科学 | 160篇 |
基础医学 | 1481篇 |
口腔科学 | 177篇 |
临床医学 | 625篇 |
内科学 | 3166篇 |
皮肤病学 | 462篇 |
神经病学 | 855篇 |
特种医学 | 756篇 |
外科学 | 2324篇 |
综合类 | 53篇 |
一般理论 | 2篇 |
预防医学 | 218篇 |
眼科学 | 173篇 |
药学 | 572篇 |
中国医学 | 22篇 |
肿瘤学 | 1210篇 |
出版年
2023年 | 57篇 |
2022年 | 118篇 |
2021年 | 242篇 |
2020年 | 165篇 |
2019年 | 180篇 |
2018年 | 236篇 |
2017年 | 224篇 |
2016年 | 295篇 |
2015年 | 296篇 |
2014年 | 411篇 |
2013年 | 483篇 |
2012年 | 668篇 |
2011年 | 776篇 |
2010年 | 508篇 |
2009年 | 440篇 |
2008年 | 772篇 |
2007年 | 796篇 |
2006年 | 805篇 |
2005年 | 812篇 |
2004年 | 743篇 |
2003年 | 712篇 |
2002年 | 785篇 |
2001年 | 112篇 |
2000年 | 89篇 |
1999年 | 147篇 |
1998年 | 217篇 |
1997年 | 167篇 |
1996年 | 187篇 |
1995年 | 156篇 |
1994年 | 124篇 |
1993年 | 114篇 |
1992年 | 89篇 |
1991年 | 79篇 |
1990年 | 82篇 |
1989年 | 62篇 |
1988年 | 51篇 |
1987年 | 44篇 |
1986年 | 39篇 |
1985年 | 33篇 |
1984年 | 42篇 |
1983年 | 26篇 |
1982年 | 31篇 |
1981年 | 37篇 |
1980年 | 37篇 |
1979年 | 15篇 |
1978年 | 15篇 |
1977年 | 13篇 |
1976年 | 14篇 |
1973年 | 7篇 |
1971年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
31.
Toshifumi Gabata Osamu Matsui Masumi Kadoya Jun Yoshikawa Kazuhiko Ueda Yasuhiro Kawamori Tsutomu Takashima 《Journal of magnetic resonance imaging : JMRI》1997,7(5):855-857
The purpose of this study was to determine the relationship between segmental hyperintensity of the liver on T1-weighted images and segmental cholestasis in patients with obstructive jaundice. T1-weighted and T2-weighted MR images were obtained of 73 patients with obstructive jaundice caused by various diseases. Fat-suppressed T1-weighted images were also obtained of 10 patients. Eleven patients with segmental intra-hepatic bile duct dilatation (cholestasis) showed segmental hyperintensity on T1-weighted images and/or fat-suppressed T1-weighted images and no signal intensity difference on T2-weighted images. Sixty-two patients with widespread intrahepatic bile duct dilatation showed no intensity difference on T1-weighted and T2-weighted images (P < .01). Segmental hyperintensity on T1-weighted images was correlated with intrahepatic cholestasis. 相似文献
32.
Naoya Emoto Eiji Ohmura Osamu Isozaki Toshio Tsushima Kazuo Shizume Hiroshi Demure 《Clinical endocrinology》1991,34(5):377-382
In order to study the mechanism of GH secretion from somatotroph adenoma cells, we have compared the effect of 12–O-tetradecanoyl phorboi-13-acetate (TPA) with that of growth hormone releasing factor (GRF) on GH secretion from human somatotroph adenoma cells cultured in monolayer. Pituitary adenoma cells were obtained from 13 patients with acromegaly undergoing surgery. On the 7th day of culture, the cells were exposed for 2 h to secretagogues. All 13 adenoma cell cultures (100%) responded to TPA (1·6–16·0 nmol/I) with a two- to six-fold increase in GH release (240·37% Increase of control: mean±SE). The response was detectable within 10 min, and was maximal at 2 h. Phosphollpase C (7·7 mmol/I) also stimulated a two-to ten-fold Increase In GH release in all four adenomas examined (100%). GH release was stimulated by GRF (2·0 nmol/I) in eight out of 12 adenoma cells (67%), but the magnitude of the responses to GRF (60·18% Increase of control: mean ± SE) were much smaller than that of TPA. Five out of 13 adenomas secreted detectable amount of PRL Into the medium and these five adenomas (100%) responded to TPA (16·0 nmol/I) with a two- to six-fold Increase. These observations indicate that the activation of protein kinase C is the consistent stimulator in GH and PRL secretion In human somatotroph adenoma cells. However, It is not determined whether the protein kinase C 相似文献
33.
Ken Kodama Osamu Doi Masahiko Higashiyama Hideoki Yokouchi Keiko Kuriyama 《Surgery today》1997,27(12):1123-1130
Between 1969 and 1995, 180 patients underwent complete resection of lung metastases during initial thoracotomy at our institute,
involving the resection of 917 pulmonary nodules at 202 thoracotomy procedures. The overall postmetastasectomy 5- and 10-year
survival rates were 46% and 30%, respectively. Of 111 patients who underwent segmentectomy and/or local excision, 57 had multiple
metastases, 39 of whom were treated by Nd:YAG laser after 1986, and 18 by conventional procedures before 1985. The average
number of tumors resected per patient treated with the Nd:YAG laser was significantly greater than that of those treated with
conventional procedures. However, the survival curve of the laser-treated group was better than that of the laser-nontreated
group. Moreover, slightly better survival was achieved in patients operated on after 1992 compared with those operated on
before 1991. We conclude that the laser technique may be warranted to afford complete resection of metastases and adequate
pulmonary reservation in combination with a selected approach for thoracotomy under the exact detection of tumor localization
using the most recent high-quality computed tomography (CT) scan. Furthermore, a one-stage operation to control synchronous
intra- and extrapulmonary malignamcies may become a possible option in combination with selective adjunctive therapy. 相似文献
34.
Takao Hashimoto Osamu Sasaki Kunihiro Yoshida Yo-ichi Takei Shu-ichi Ikeda 《Movement disorders》2003,18(10):1201-1204
We report on a family with ataxia type 6 (SCA6) showing peculiar oculomotor symptoms. The proband presented with periodic alternating nystagmus (PAN), and her 2 brothers had rebound nystagmus and gaze-evoked nystagmus. They carried the identical mutation (the number of expanded CAG repeat, 24) in the CACNA1A gene. The intrafamilial variability of oculomotor symptoms may be ascribed to factors other than CAG repeat expansion size in SCA6. 相似文献
35.
Akihiro Hosaka M.D. Tetsuro Miyata M.D. Hiroshi Shigematsu M.D. Jun-o Deguchi M.D. Hideo Kimura M.D. Hirokazu Nagawa M.D. Osamu Sato M.D. Takehiko Sakimoto M.D. Tomoyuki Mochizuki M.D. 《Journal of gastrointestinal surgery》2006,10(4):583-585
The vascular type of Ehlers-Danlos syndrome is a genetic disorder of connective tissue and is frequently associated with catastrophic
arterial complications. Its surgical treatment is extremely difficult because of the fragility of vessels. This article describes
three patients with vascular type of Ehlers-Danlos syndrome who developed mesenteric hemorrhage due to spontaneous arterial
rupture. The clinical and molecular characteristics of the disease are briefly reviewed. 相似文献
36.
Hironari Takaishi Osamu Nemoto Masanobu Shiota Toshiyuki Kikuchi Harumoto Yamada Masaaki Yamagishi Yutaka Yabe 《Journal of orthopaedic research》1997,15(4):528-538
To clarify phenotypic alterations of intervertebral disc cells during the repair process, we cloned partial type-II collagen cDNA from rabbits and analyzed the level of expression of type-II collagen mRNA in disc degeneration. An animal model was created by surgical denucleation of rabbit intervertebral discs through, an extraperitoneal approach. Eight animals each from an experimental and a control group were killed at 2, 4, 8, or 16 weeks postoperatively, and the disc samples were used for this study. Round chondrorcyte-like cells that filled the herniated space showed intense signal of type-II collagen mRNA and significant pericellular immunostaining of type-II collagen but no clear staining of type-I collagen. Northern. blot analysis revealed that the expression of type-II collagen mRNA of the repair disc cells was transiently increased at 4 weeks postoperatively. The cells were able to change their morphology in response to mechanical stimulation by surgical denucleation and to induce a significant increase in the gene expression of type-II collagen at an early phase of disc degeneration. The present results indicate the transient enhancement of repair activity in the degenerative process of injured fibrocartilage. 相似文献
37.
Junya Katoh Shunya Shindo Satsuki Kina Seiichiro Katahira Hiroshi Osawa Masahiro Kobayashi Osamu Suzuki Kihachiro Kamiya Yusuke Tada 《Surgery today》1995,25(6):554-556
Aneurysmal rupture into the intestinal tract is a rare but disastrous complication of an internal iliac artery aneurysm. We report herein the successful surgical repair of a fistula between a huge aneurysm of the right internal iliac artery and the rectum in an 81-year-old man. After a femoro-femoral cross-over bypass had been performed, the aneurysm was opened and its patent arterial branches were ligated with sutures. The fistula was then intra-aneurysmally sutured and covered with an omental flap. The diagnostic and therapeutic approaches to this severe complication are discussed with a review of the literature following the presentation of this case. 相似文献
38.
Ryoji Kajiwara Takahiro Matsuno Osamu Ishida Toru Sunagawa Osami Suzuki Mitsuo Ochi 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2004,38(6):373-375
We report a case of an anterior interosseous nerve palsy after closed reduction and percutaneous pinning of open fractures of the radius and ulna in an adult. Operative findings showed that the anterior interosseous nerve was trapped between the distal and proximal part of the fractured radius. Treatment by neurorrhaphy gave a satisfactory result. 相似文献
39.
Mitsuhiro Morita Harumoto Yamada Osamu Hemmi Kyosuke Fujikawa 《Journal of orthopaedic science》2004,9(1):99-102
In acetabular dysplasia of the hip joint accompanied by a giant acetabular bone cyst, rotational acetabular osteotomy may cause serious complications, such as bone necrosis after surgery or fracture of the fragile acetabulum during the operation. In a patient with this condition, we performed a two-stage operation: first, autogenous bone grafting supplemented with hydroxyapatite filling, then rotational acetabular osteotomy (after new bone formation had been assured). Radiographs and CT scans showed favorable fusion of the grafted bone. Some 18 months after the second operation, arthrograms showed no inflow of contrast medium from the articular cavity into the bone cyst region, although this had been observed before treatment. Thus, an effective remodeling of bony congruency was indicated in the mobile acetabulum 5 years after the second operation. This two-stage operation appears to be useful for correcting acetabular dysplasia accompanied by a giant bone cyst and to carry a reduced risk of serious complications, such as deterioration of the articular surface of the acetabulum or necrosis of the translocated acetabulum. 相似文献
40.
Einosuke Mizuta Toshihiro Hamada Shin-ichi Taniguchi Masaki Shimoyama Takahiro Nawada Junichiro Miake Yasuhiro Kaetsu Li Peili Kiyosuke Ishiguro Shingo Ishiguro Osamu Igawa Chiaki Shigemasa Ichiro Hisatome 《Hypertension research》2006,29(8):635-638
We report the case of a 67-year-old woman with severe hypertension caused by an extra-adrenal pheochromocytoma. The tumor was detected by 131I metaiodobenzylguanidine scintigraphy and it was found to be small (2 cm ?) by enhanced CT. After the extirpation of the tumor, the blood pressure of the patient immediately normalized. It should be taken into account that a small extra-adrenal pheochromocytoma can be one of the causes of secondary hypertension in elderly patients. Since small extra-adrenal pheochromocytomas are difficult to detect, it is also important to perform suitable examinations to establish the diagnosis. Furthermore, we emphasize the importance of an accurate diagnosis in elderly patients with pheochromocytoma, for they often have less symptomatology and more severe cardiovascular complications due to refractory hypertension than younger patients. 相似文献