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81.
82.
Quality of Diagnosis and Treatment Plans After Using the ‘Diagnostic Guideline for Anxiety and Challenging Behaviours’ in People with Intellectual Disabilities: A Comparative Multiple Case Study Design
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83.
M. M. Wentink E. Prieto A. J. de Kloet T. P. M. Vliet Vlieland J.J.L. Meesters 《Disability and rehabilitation. Assistive technology》2018,13(7):620-625
Introduction: Success of e-health relies on the extent to which the related technology, such as the electronic device, is accepted by its users. However, there has been limited research on the patients’ perspective on use of e-health-related technology in rehabilitation care.Objective: To explore the usage of common electronic devices among rehabilitation patients with access to email and investigate their preferences regarding their usage in rehabilitation.Methods: Adult patients who were admitted for inpatient and/or outpatient rehabilitation and were registered with an email address were invited to complete an electronic questionnaire regarding current and preferred use of information and communication technologies in rehabilitation care.Results: 190 out of 714 invited patients completed the questionnaire, 94 (49%) female, mean age 49?years (SD 16). 149 patients (78%) used one or more devices every day, with the most frequently used devices were: PC/laptop (93%), smartphone (57%) and tablet (47%). Patients mostly preferred to use technology for contact with health professionals (mean 3.15, SD 0.79), followed by access to their personal record (mean 3.09, SD 0.78) and scheduling appointments with health professionals (mean 3.07, SD 0.85).Conclusion: Most patients in rehabilitation used one or more devices almost every day and wish to use these devices in rehabilitation.
- Implications for Rehabilitation
In a sample of 190 patients in rehabilitation with access to email, almost all patients used one or more electronic devices almost every day of the week, with the most frequently used devices were: a PC/laptop, smartphone and tablet.
Most of the patients wish to incorporate electronic devices in their rehabilitation process and prefer to use those devices to have insight in their health record, communication with peers and scheduling appointments with health professionals.
To better assist patients with e-health in rehabilitation care in the future, preferences could be implemented in rehabilitation care by using the most commonly used devices.
84.
M. M. Wentink J. Meesters M. A. M. Berger A. J. de Kloet E. Stevens G. P. H. Band 《Topics in stroke rehabilitation》2013,20(5):359-365
Background Computer-based cognitive rehabilitation is used to improve cognitive functioning after stroke. However, knowledge on adherence rates of stroke patients is limited.Objective To describe stroke patients’ adherence with a brain training program using two frequencies of health professionals’ supervision.Methods This study is part of a randomized controlled trial comparing the effect of the brain training program (600 min playtime with weekly supervision) with a passive intervention in patients with self-perceived cognitive impairments after stroke. Patients randomized to the control condition were offered the brain training after the trial and received supervision twice (vs weekly in intervention group). Adherence was determined using data from the study website. Logistic regression analyses were used to examine the impact of supervision on adherence.Results 53 patients allocated to the intervention group (group S8; 64% male, mean age 59) and 52 patients who were offered the intervention after the trial (group S2; 59% male, mean age 59) started the brain training. The median playtime was 562 min (range 63–1264) in group S8 vs. 193 min (range 27–2162) in group S2 (p < 0.001, Mann Whitney U).Conclusions The overall adherence of stroke patients with a brain training was low and there are some implications that systematic, regular interaction with a supervisor can increase training adherence of stroke patients with a restitution-focused intervention performed at home. 相似文献
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Maaike Schilperoort Rosa van den Berg Laura A. Bosmans Bram W. van Os Martijn E. T. Dollé Noortje A. M. Smits Teun Guichelaar Debbie van Baarle Lotte Koemans Jimmy F. P. Berbée Tom Deboer Johanna H. Meijer Margreet R. de Vries Dianne Vreeken Janine M. van Gils Ko Willems van Dijk Linda W. M. van Kerkhof Esther Lutgens Nienke R. Biermasz Patrick C. N. Rensen Sander Kooijman 《Journal of pineal research》2020,68(1):e12614
Disruption of circadian rhythm by means of shift work has been associated with cardiovascular disease in humans. However, causality and underlying mechanisms have not yet been established. In this study, we exposed hyperlipidemic APOE*3-Leiden.CETP mice to either regular light-dark cycles, weekly 6 hours phase advances or delays, or weekly alternating light-dark cycles (12 hours shifts), as a well-established model for shift work. We found that mice exposed to 15 weeks of alternating light-dark cycles displayed a striking increase in atherosclerosis, with an approximately twofold increase in lesion size and severity, while mice exposed to phase advances and delays showed a milder circadian disruption and no significant effect on atherosclerosis development. We observed a higher lesion macrophage content in mice exposed to alternating light-dark cycles without obvious changes in plasma lipids, suggesting involvement of the immune system. Moreover, while no changes in the number or activation status of circulating monocytes and other immune cells were observed, we identified increased markers for inflammation, oxidative stress, and chemoattraction in the vessel wall. Altogether, this is the first study to show that circadian disruption by shifting light-dark cycles directly aggravates atherosclerosis development. 相似文献
88.
Noortje Gerritsma Maartje-Maria van den Berg Ali Khader Majed Hababeh Loai Farajallah Ishtaiwi Abu-Zayed Mohammad Ashraf Ghada Ballout Akihiro Seita 《Lancet》2018
Background
The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides primary health care for Palestinian refugees in the Middle East. Recently, a family health-team approach was implemented to provide patient-centred instead of disease-centred care. Teams comprise at least one doctor, one nurse, and one clerk, and each team is appointed a certain number of families. The aim of this study was to assess the effect of this approach on the quality of infant care in Jordan.Methods
In this cross-sectional study, we compared care in an intervention health centre with care in a control centre. Data on the effectiveness of care of all infants aged 19–23 months were collected through medical record review between April and June, 2014. Effectiveness was assessed comparing immunisation, anaemia, and growth monitoring data. Patient-centeredness was assessed through semi-structured interviews with parents. Written consent was provided by all participants. Ethical approval was obtained from UNRWA's Ethics Office.Findings
The parents of 437 infants were included in the intervention group, and the parents of 552 infants were included in the control group. The odds for attending all growth monitoring visits were higher in the intervention group than in the control group (odds ratio [OR] 2·8, 95% CI 1·90–4·34). The odds for receiving iron to treat anaemia were also higher in the intervention group than in the control group (4·76, 1·28–17·7). We found no difference in anaemia screening rates (0·75, 0·40–1·40), attendance of follow-up visits for anaemia (0.7, 0·29–1·69), or vaccination rates (1·20, 0·68–2·11). Interviews (n=11) revealed waiting times at health centres to be perceived as barriers for parents when seeking care for their infants. Acceptability and continuity of care were not perceived as barriers.Interpretation
Whereas the family health-team approach has the potential to improve infant care in terms of growth monitoring and anaemia treatment, results might be attributable to other causes as data used in this study date back to when the approach had only been implemented for 3 months.Funding
Fondsendesk, VU University Amsterdam, the Netherlands, the Health Department, United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) Headquarters, Amman, Jordan. 相似文献89.
90.
Hoogeveen-Westerveld M Wentink M van den Heuvel D Mozaffari M Ekong R Povey S den Dunnen JT Metcalfe K Vallee S Krueger S Bergoffen J Shashi V Elmslie F Kwiatkowski D Sampson J Vidales C Dzarir J Garcia-Planells J Dies K Maat-Kievit A van den Ouweland A Halley D Nellist M 《Human mutation》2011,32(4):424-435
The effects of missense changes and small in-frame deletions and insertions on protein function are not easy to predict, and the identification of such variants in individuals at risk of a genetic disease can complicate genetic counselling. One option is to perform functional tests to assess whether the variants affect protein function. We have used this strategy to characterize variants identified in the TSC1 and TSC2 genes in individuals with, or suspected of having, Tuberous Sclerosis Complex (TSC). Here we present an overview of our functional studies on 45 TSC1 and 107 TSC2 variants. Using a standardized protocol we classified 16 TSC1 variants and 70 TSC2 variants as pathogenic. In addition we identified eight putative splice site mutations (five TSC1 and three TSC2). The remaining 24 TSC1 and 34 TSC2 variants were classified as probably neutral. 相似文献