全文获取类型
收费全文 | 3777篇 |
免费 | 208篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 84篇 |
妇产科学 | 37篇 |
基础医学 | 574篇 |
口腔科学 | 61篇 |
临床医学 | 254篇 |
内科学 | 1019篇 |
皮肤病学 | 43篇 |
神经病学 | 254篇 |
特种医学 | 125篇 |
外科学 | 743篇 |
综合类 | 8篇 |
预防医学 | 85篇 |
眼科学 | 34篇 |
药学 | 196篇 |
中国医学 | 2篇 |
肿瘤学 | 440篇 |
出版年
2023年 | 21篇 |
2022年 | 35篇 |
2021年 | 68篇 |
2020年 | 37篇 |
2019年 | 55篇 |
2018年 | 72篇 |
2017年 | 60篇 |
2016年 | 89篇 |
2015年 | 78篇 |
2014年 | 108篇 |
2013年 | 170篇 |
2012年 | 222篇 |
2011年 | 243篇 |
2010年 | 136篇 |
2009年 | 108篇 |
2008年 | 215篇 |
2007年 | 217篇 |
2006年 | 248篇 |
2005年 | 237篇 |
2004年 | 238篇 |
2003年 | 204篇 |
2002年 | 215篇 |
2001年 | 83篇 |
2000年 | 88篇 |
1999年 | 72篇 |
1998年 | 78篇 |
1997年 | 65篇 |
1996年 | 39篇 |
1995年 | 41篇 |
1994年 | 34篇 |
1993年 | 39篇 |
1992年 | 37篇 |
1991年 | 41篇 |
1990年 | 36篇 |
1989年 | 40篇 |
1988年 | 29篇 |
1987年 | 27篇 |
1986年 | 30篇 |
1985年 | 19篇 |
1984年 | 18篇 |
1983年 | 17篇 |
1982年 | 10篇 |
1981年 | 10篇 |
1979年 | 10篇 |
1978年 | 7篇 |
1977年 | 9篇 |
1975年 | 9篇 |
1974年 | 8篇 |
1971年 | 7篇 |
1968年 | 5篇 |
排序方式: 共有4018条查询结果,搜索用时 15 毫秒
101.
Eiji Masuda Sunao Kawano Kouichi Nagano Shingo Tsuji Yoshitaka Ishigami Nobuhiko Hayashi Masahiko Tsujii Yoshiaki Sasayama Tomoki Michida Hideyuki Fusamoto et al. 《Journal of gastroenterology》1991,26(Z3):81-82
The effects of ethanol on gastric vasculature in isolated vascularly perfused rabbit stomach was investigated. The isolated
stomach was perfused with Krebs-Henseleit solution containing 3% dextran bubbled with 95% O2 and 5% CO2 at a rate of 12 ml/min. After mixture and perfusion of 10 mM to 400 mM of ethanol, perfusion pressure and endothelin-1 concentration
in effluent from gastric vasculature were measured. Perfusion pressure and endothelin-1 concentration in effluent increased
in a dose-dependent manner with increasing ethanol concentrations. In conclusion, the data suggest that ethanol may stimulate
the release of endothelin from gastric vasculature and may cause gastric ischemia due to vasoconstriction resulting in acute
gastric mucosal injury. 相似文献
102.
Yohei Kawaguchi Masayuki Nakao Kenshiro Omura Naoya Iwamoto Hiroki Ozawa Yasuto Kondo Junji Ichinose Yosuke Matsuura Sakae Okumura Mingyon Mun 《Journal of thoracic disease》2020,12(12):7218
BackgroundIt is critical to have an accurate measurement of solid tumor size in order to predict the invasiveness of small lung adenocarcinomas. Some lesions cannot be measured accurately via High-resolution computed tomography (HRCT) due to their irregular shape and unclear borders. For this reason, we evaluated the relative efficacy of three-dimensional (3D) CT for predicting invasive adenocarcinoma.MethodsWe evaluated 195 patients with clinical stage IA adenocarcinomas, including 109 with lesions documented as invasive that were surgically resected at our institute during 2017. All lesions were categorized as either (I) lesions that were difficult to evaluate (i.e., hazy lesions; HL) or (II) more typical lesions (TL). The relationships between solid tumor size as determined by HRCT, solid tumor volume as determined by 3D CT and pathologic diagnosis were evaluated.ResultsFifty-seven patients (29%) were diagnosed with HL. We set the cut-off value for the solid volume at 225 mm3 as predictive for invasive adenocarcinoma. When evaluating all 195 patients as a group, the accuracy, sensitivity, and specificity based on the solid tumor volume were similar to those based on the solid tumor size. When we limit our analysis to the HL group, the specificity based on solid tumor volume (65.5%) was higher than that based on solid tumor size (44.8%) with a difference that approached statistical significance (P=0.070).Conclusions3D CT was equivalent to HRCT for predicting invasive adenocarcinoma and may be particularly useful for diagnosing lesions that are difficult to evaluate on HRCT. 相似文献
103.
Tomokazu Kawaoka Shoichi Takahashi Yumiko Tatsukawa Akira Hiramatsu Nobuhiko Hiraga Daiki Miki Masataka Tsuge Michio Imamura Yoshiiku Kawakami Hiroshi Aikata Hidenori Ochi Kouhei Ishiyama Kentaro Ide Hirotaka Tashiro Hideki Ohdan Kazuaki Chayama 《Hepatology research》2014,44(12):1259-1264
It is difficult to use protease inhibitors in patients with recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) due to interaction with immunosuppressive drugs. We report our experience with two patients treated with telaprevir (TVR) combined with pegylated interferon/ribavirin (PEG IFN/RBV) for recurrent HCV genotype 1 infection after LT. The first was a 63‐year‐old man with HCV‐related liver cirrhosis, who failed to respond to IFN‐β plus RBV after LT. Treatment was switched to PEG IFN‐α‐2b plus RBV and TVR was started. The donor had TT genotype of interleukin (IL)‐28 single nucleotide polymorphisms (SNP) (rs8099917). The recipient had TT genotype of IL‐28 SNP (rs8099917). Completion of 12‐week triple therapy was followed by PEG IFN‐α‐2b plus RBV for 36 weeks. Finally, he had sustained viral response. The second was a 70‐year‐old woman with HCV‐related liver cirrhosis and hepatocellular carcinoma. She failed to respond to PEG IFN‐α‐2b plus RBV after LT, and was subsequently switched to PEG IFN‐α‐2b/RBV/TVR. Genotype analysis showed TG genotype of IL‐28 SNP for the donor, and TT genotype of IL‐28 SNP for the recipient. Serum HCV RNA titer decreased below the detection limit at 5 weeks. However, triple therapy was withdrawn at 11 weeks due to general fatigue, which resulted in HCV RNA rebound 4 weeks later. Both patients were treated with cyclosporin, starting with a small dose to avoid interactions with TVR. TVR is a potentially suitable agent for LT recipients who do not respond to PEG IFN‐α‐2b plus RBV after LT. 相似文献
104.
105.
Akazawa S Tojikubo M Nakano Y Nakamura S Kawasaki T Koga N 《Diabetes research and clinical practice》2012,96(2):111-118
106.
Ichinose K Origuchi T Kawashiri SY Iwamoto N Fujikawa K Aramaki T Kamachi M Arima K Tamai M Nakamura H Ida H Kawakami A Eguchi K 《Rheumatology international》2012,32(2):483-487
We present six cases of patients with Japanese rheumatoid arthritis (RA) treated with a tumor necrosis factor (TNF)-alpha blocking agent, adalimumab as monotherapy for 220?weeks. All six patients were women, and the median age was 54.0?±?7.07?years old. The median duration of the disease was 7.43?±?11.1?years, and the median disease activity score (DAS28-CRP) was 5.35?±?0.69. Three of six patients were able to continue to receive this treatment for 220?weeks successfully, and the DAS28-CRP decreased to 1.89?±?0.75. Two patients withdrew because of lack of efficacy, and one patient withdrew because of adverse events (non-Hodgkin lymphoma). Adalimumab resulted in a sustained clinical response in RA patients during 220-week follow-up. 相似文献
107.
Nobuhiko Haga Masaya Kubota Zenzo Miwa 《American journal of medical genetics. Part A》2013,161(4):871-874
Hereditary sensory and autonomic neuropathy (HASN) refers to a group of rare congenital disorders characterized by loss of pain sensation and other sensory or autonomic abnormalities. Among them, a relatively large proportion of patients with HSAN type IV, which is accompanied by anhidrosis and intellectual disability, are reported from Israel and Japan. HSAN type V, with normal sweating and mental development, is rarely reported in Japan. In 2009, we founded a research group for congenital insensitivity to pain and performed the first epidemiological survey of HSAN types IV and V in Japan. Questionnaires were sent to a total of 3,488 certified training institutions of five nationwide medical societies comprising pediatricians, neurologists, orthopedic surgeons, and dentists. Answers were obtained from 1,610 institutions, and 192 HSAN patients (152 with type IV and 28 with type V) were reported from 105 institutions. After excluding duplicated patients, we identified a total of 62 current, 36 past, and five deceased patients for HSAN‐IV, and a total of 14 current, 13 past, and 0 deceased patients for HSAN‐V. Using these figures, we estimated that the number of Japanese patients with HSAN types IV and V as 130–210 and 30–60 patients, respectively. We identified no gender differences, and patients with a family history of the disorder were limited to affected siblings in both conditions. Most patients with HSAN‐IV were 5–40 years of age, whereas half of the patients with HSAN‐V were 40 years or older. © 2013 Wiley Periodicals, Inc. 相似文献
108.
Coagulation factor XIII/13 (FXIII/13) stabilizes fibrin molecules by creating crosslinks with other fibrin molecules as well
as with α2-plasmin inhibitor (α2-PI). “Hemorrhagic acquired FXIII/13 deficiency” was formerly considered rare, but has been increasing recently in Japan.
During the 10 months of our nationwide campaign, we diagnosed five new patients with “acquired hemorrhaphilia due to anti-FXIII/13
autoantibodies,” after examining 20 newly suspected cases of “hemorrhagic acquired FXIII/13 deficiency.” When FXIII/13 activity
was reduced to less than 50% of normal, it was proportional to the difference in α2-PI levels between plasma and serum (plasma–serum α2-PI), likely due to its cross-linking to fibrin by activated FXIII/13. Accordingly, decreased amounts of the plasma–serum
α2-PI ex vivo may reflect reduced FXIII/13 activity in vivo. The plasma–serum α2-PI may thus also be a useful diagnostic marker for severe FXIII/13 deficiency. 相似文献
109.
Senji Kasahara Hisashi Tsurumi Yuhei Shibata Takuro Matsumoto Nobuhiko Nakamura Hiroshi Nakamura Nobuhiro Kanemura Naoe Goto Takeshi Hara Hisataka Moriwaki 《International journal of hematology》2012,96(5):674-678
We describe two patients with T cell prolymphocytic leukemia (T-PLL) who exhibited the same complex karyotype, including an additional segment at 1p36.1. One presented with secondary progression following an initial stable clinical course, and the other with typically progressive disease. Features of the cerebriform variant were identified in the peripheral blood of both patients. Aggressive symptoms, such as lymphocytosis, lymphadenopathy, pleural effusion, cutaneous involvement and hepatosplenomegaly, developed during the progressive phases. Levels of serum soluble interleukin 2 receptor increased when symptoms worsened. These patients did not have the karyotypic 14q11 abnormality and trisomy 8q that are features of non-Japanese patients. The prognoses of these patients were poor; one survived for 2 months and the other survived for 10 months after progression. A chromosomal abnormality may occur in other types of aggressive T-PLL, particularly when extramedullary infiltration is a feature. 相似文献
110.
Murakami H Gando S Hayakawa M Sawamura A Sugano M Kubota N Uegaki S Jesmin S 《Clinical and applied thrombosis/hemostasis》2012,18(4):364-369
The data from 254 patients with severe trauma were retrospectively analyzed. The patients were subdivided into disseminated intravascular coagulation (DIC) and non-DIC. There was a difference in the incidence of the continuous progression from the early to late phase of DIC between the patients with and without DIC on day 0. While 2 of 9 patients who newly developed late-phase DIC were complicated with sepsis, none of the 32 patients who showed a continuous progression of DIC from the early to late phase of trauma developed sepsis. The DIC and Sequential Organ Failure Assessment scores on day 0 were independent factors that predicted the continuous progression of the DIC from the early to late phase of trauma. Trauma itself, but not sepsis, contributes to the continuous progression of DIC from the early to late phase of trauma. The severity of DIC and organ dysfunction are involved in the pathogenesis of this continuous progression. 相似文献