全文获取类型
收费全文 | 539篇 |
免费 | 82篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 22篇 |
妇产科学 | 3篇 |
基础医学 | 50篇 |
口腔科学 | 4篇 |
临床医学 | 34篇 |
内科学 | 124篇 |
皮肤病学 | 2篇 |
神经病学 | 25篇 |
特种医学 | 17篇 |
外科学 | 64篇 |
综合类 | 101篇 |
预防医学 | 49篇 |
眼科学 | 14篇 |
药学 | 59篇 |
中国医学 | 24篇 |
肿瘤学 | 54篇 |
出版年
2023年 | 4篇 |
2021年 | 17篇 |
2020年 | 26篇 |
2019年 | 27篇 |
2018年 | 18篇 |
2017年 | 22篇 |
2016年 | 21篇 |
2015年 | 28篇 |
2014年 | 21篇 |
2013年 | 29篇 |
2012年 | 21篇 |
2011年 | 30篇 |
2010年 | 30篇 |
2009年 | 22篇 |
2008年 | 12篇 |
2007年 | 25篇 |
2006年 | 12篇 |
2005年 | 19篇 |
2004年 | 33篇 |
2003年 | 55篇 |
2002年 | 44篇 |
2001年 | 52篇 |
2000年 | 25篇 |
1999年 | 13篇 |
1998年 | 11篇 |
1997年 | 14篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 1篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1983年 | 2篇 |
1967年 | 2篇 |
排序方式: 共有648条查询结果,搜索用时 15 毫秒
91.
模拟临床灌洗方法对染尘家兔进行大容量肺灌洗,并观察灌洗前后肺泡液中细胞及生化成分变化,为灌洗术的应用性评价提供科学依据。结果显示:灌洗后染尘动物肺泡液中除总磷脂,二棕榈酰卵磷脂(DPPC)外,细胞总数、蛋白质含量、乳酸脱氢酶(LDH)、碱性磷酸酶(AKP)活性均明显低于同期染尘未灌洗组,差异有显著性,此外还可洗出一定量的SiO2粉尘,首次灌洗较第二次灌洗为多。提示:灌洗对矽肺发生发展有一定延缓作用,早期灌洗效果较好。 相似文献
92.
研究煤矿井下工人实际接尘工龄及脱尘率对评价粉尘危险度,进行尘肺发病预测具有重要意义,笔者采用回顾性队列研究方法,对某煤矿1958~1988年入矿工人实际接尘工龄及脱尘情况进行分析,结果表明:(1)工种对接尘工龄有影响,例如接尘10年时,采煤工累积脱尘概率为32.36%,掘进工为21.94%,辅助工为21.65%,判别非常显著;(2)接尘工龄与工人进行矿年代有关,累积脱尘率达30%时,1958~19 相似文献
93.
94.
Ammonia clearance by peritoneal dialysis and continuous arteriovenous hemodiafiltration 总被引:4,自引:2,他引:2
Kar Yin Wong Sik Nin Wong Shu Yan Lam Sidney Tam Nai Shun Tsoi 《Pediatric nephrology (Berlin, Germany)》1998,12(7):589-591
We report the use of continuous arteriovenous hemodiafiltration (CAVHD) in a neonate with severe hyperammonemia due to a
urea cycle disorder. We compared the ammonia clearance (C
NH3) for peritoneal dialysis (PD) and CAVHD. C
NH3 for CAVHD was 7.45 ml/min per m2 at a dialysate flow of 300 ml/h and was 10.55 ml/min per m2 at a dialysate flow rate of 600 ml/h. The mean PD clearance was 2.15 ml/min per m2. Our data suggest that CAVHD is superior to PD for the removal of plasma ammonia. We conclude that CAVHD should be considered
a reasonable alternative in the treatment of neonatal hyperammonemia in urea cycle disorders when medical treatment fails.
Received September 2, 1997; received in revised form Feburary 26, 1998; accepted March 2, 1998 相似文献
95.
Nai A Pagani A Silvestri L Campostrini N Corbella M Girelli D Traglia M Toniolo D Camaschella C 《Blood》2011,118(16):4459-4462
The iron hormone hepcidin is inhibited by matriptase-2 (MT2), a liver serine protease encoded by the TMPRSS6 gene. Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mothers against decapentaplegic homologs (SMAD) signaling pathway, down-regulates hepcidin, and facilitates iron absorption. TMPRSS6 inactivation causes iron-deficiency anemia refractory to iron administration both in humans and mice. Genome-wide association studies have shown that the SNP rs855791, which causes the MT2 V736A amino acid substitution, is associated with variations of serum iron, transferrin saturation, hemoglobin, and erythrocyte traits. In the present study, we show that, in vitro, MT2 736(A) inhibits hepcidin more efficiently than 736(V). Moreover, in a genotyped population, after exclusion of samples with iron deficiency and inflammation, hepcidin, hepcidin/transferrin saturation, and hepcidin/ferritin ratios were significantly lower and iron parameters were consistently higher in homozygotes 736(A) than in 736(V). Our results indicate that rs855791 is a TMPRSS6 functional variant and strengthen the idea that even a partial inability to modulate hepcidin influences iron parameters and, indirectly, erythropoiesis. 相似文献
96.
97.
Nai‐Lee LUI Julian THUMBOO Kok‐Yong FONG 《International journal of rheumatic diseases》2009,12(4):366-369
Large refractory vasculitic ulcers are not commonly seen in systemic lupus erythematosus (SLE) patients. We report a case of refractory vasculitic ulcers responding to rituximab, a monoclonal antibody directed against CD20 cells leading to prolonged B cell depletion. This treatment was initiated after treatment with high‐dose steroids and other immunosuppressants were ineffective/associated with significant side‐effects. Following treatment with rituximab, there was sustained clinical improvement and subsequent reduction of prednisolone dose. Rituximab was well‐tolerated. Concomitant methotrexate therapy and hyperbaric oxygen therapy (HBOT) may have aided the recovery of the patient’s vasculitic ulcers. This case and anecdotal reports have illustrated the efficacy and safety of rituximab in the treatment of refractory SLE‐related vasculitic ulcers. Further studies to determine the long‐term efficacy and side‐effects would be useful. 相似文献
98.
99.
100.
Kam Lun Hon Nga Hin Pong Shuxin Susan Wang Vivian W. Lee Nai Ming Luk Ting Fan Leung 《Drugs in R&D》2013,13(1):37-42