黄甘草皂甙的结构

本文报道自黄甘草(Glycyrrhiza eurycarpa P.C.Li)根茎中获得两个皂甙化合物K-3和K-4。根据理化性质和光谱数据鉴定K-4为3-β-羟基-11-氧化-齐墩果-12-烯-30-羧酸-3-O-β-D-吡喃葡萄糖醛酸基(1→4)-β-D-吡喃葡萄糖醛酸甙,为一新的天然产物,命名为黄甘草皂甙(glyeurysaponin)。K-3为已知皂甙乌拉尔甘草皂甙乙(uralsaponin B)。二者均为首次从该种植物中获得。本文报道化合物K-4的结构鉴定。     

A case of macroprolactinoma and elevated insulin-like growth factor-I in a young boy

We report a case of a 10-y-old boy who presented with persistent headache and was found to have a giant prolactinoma. Laboratory evaluation revealed markedly elevated prolactin (PRL) level, thyroid-stimulating hormone (TSH) deficiency, and elevated insulin-like growth factor-I (IGF-I). He had normal random growth hormone (GH) but non-suppressible GH during oral glucose tolerance test (OGTT). Cabergoline treatment was initiated and was well tolerated. Therapy successfully reduced PRL levels, normalized IGF-I levels, and reduced tumor size. CONCLUSION: Our patient presented with a GH-PRL-secreting tumor. Dopamine agonists are recommended as the treatment of choice for prolactinomas. However, there should be careful attention to GH status when treating GH-PRL-secreting tumor with dopamine agonists alone. IGF-I levels should be followed in all patients with prolactinoma, even in those with normal basal GH concentrations, because of the possibility of GH co-secretion.     

乙酰丹酚酸 A──一种新型血栓素合成酶抑制剂

乙酰丹酚酸Ａ一种新型血栓素合成酶抑制剂吁文贵徐理纳（中国医学科学院、中国协和医科大学药物研究所，北京１０００５０）乙酰丹酚酸Ａ（ａｃｅｔｙｌｓａｌｖｉａｎｏｌｉｃａｃｉｄＡ，ＡＳＡＡ）有抗血小板功能作用［１］，且能明显抑制花生四烯酸（ＡＡ）代谢产物血...     

噻芬太尼的主要药效和致依赖性潜力的实验研究

本文研究噻芬太尼的镇痛药效和制动作用,评价其致身体依赖性潜力。小鼠热板法测得噻芬太尼的镇痛作用强度分别为吗啡、芬太尼和埃托啡的3260,22和1.5倍。以瘫痪作为制动指标测得噻芬太尼对大鼠、家兔、狗和猴制动作用强度为埃托啡的2～3倍。小鼠跳跃实验和大鼠饮药液自然戒断实验表明该药具有一定致身体依赖性潜力。大鼠ⅳ快速成瘾实验及长达20周的猴身体依赖性实验则未出现依赖性戒断症状。     

Transcatheter embolization in the management of pulmonary hemorrhage

A group of 306 patients with acute pulmonary hemorrhage were evaluated by means of bronchial arteriography and treated with transcatheter embolization. Specific causes for bleeding included lung abscess, chronic pneumonia, tuberculosis, lung cancer, and bronchiectasis. In 120 patients the hemoptysis was massive, with volumes exceeding 500 ml/day. The majority (n = 225) were treated during peak hemorrhage. Embolization was performed with one of three methods: particulate embolization with polyurethane or velour, obturation with the angiographic catheter combined with peripheral embolization by means of infused albumin macroaggregates, and regional infusion of sclerosing agents. Effective hemostasis was obtained initially in 278 patients (90.8%), including 87.5% of those treated during peak hemorrhage. In 26 of 28 cases without initial response, the pulmonary artery was the source of bleeding. Recurrent bleeding, within 1-4 days, requiring surgery was observed in 39 patients with initially successful hemostasis. Of 158 patients who were treated without surgery, subsequent episodes of hemoptysis occurred in 36. Combined methods of embolization may improve the efficacy of treatment of operable and inoperable patients with lung disease complicated by hemorrhage.     

Molecular properties prediction, synthesis, and diuretic activity of phenoxy acetic acid bearing pyrazolines

A new series of phenoxyacetic acid bearing pyrazoline derivatives 7a–k were synthesized and characterized by IR, ¹H-NMR, and mass spectral data. The investigated compounds were screened for their diuretic activity by standard Lipschitz method. Furthermore, the series under investigation were assessed for their drug-likeness by suitable software programs. These compounds were found to have promising results against a given set of diuretic parameters, i.e., cumulative urine output, diuretic activity, diuretic action, and Lipchitz values. Nevertheless, compounds 7d, 7h, 7i, and 7k bearing electron withdrawing group (Cl^?) showed pronounced diuretic propensity than the standard furosemide.     

CT findings of omental torsion and infarction: case report and review of the literature

A 37-year-old woman presented with progressive diffuse abdominal pain. Computed tomography (CT) showed diffuse streaking of the greater omentum with a mass of fat density located anteriorly just below the umbilicus, showing a whirling pattern of concentric streaks. Surgery and pathology revealed torsion and infarction of the greater omentum. Because of its rarity and nonspecific clinical features, the diagnosis is seldom made preoperatively. We describe a patient with characteristic CT findings of omental torsion. Preoperative diagnosis is important since conservative management has been suggested.