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Prajna Pramod Nayak Sushma S. Nayak Deepicca Sathiyabalan NK Aditya Priyanjana Das 《Journal of cancer education》2018,33(6):1250-1254
Although current oral health care initiatives have proved to be quite successful, a great number of individuals are unaware of how their choice of daily activities compromises their oral health. That is why newer technologies like WhatsApp can definitely serve as a platform to communicate dental advice, thereby strengthening the bridge between health and technology. The objective of the study was to assess the effectiveness of WhatsApp as a tool for providing health education on tobacco and oral cancer as compared to the conventional health education via PowerPoint. The study was a cluster randomized controlled trial, single-center study. The students of 18–24 years of age with WhatsApp application active in their mobile phones were included. Four classes with 182 students were randomly divided into intervention and control groups. Control group received health education on oral cancer using a PowerPoint presentation weekly, for a total of 4 weeks. Intervention group received health education through WhatsApp messaging thrice a week for 4 weeks. Pre- and post-health education knowledge scores were assessed using a questionnaire and compared using unpaired and paired two-sample t tests. Statistically significant increase in knowledge scores was seen in both groups, with highly significant improvement in the intervention group (p value = 0.00). Intergroup comparison showed no significant difference in knowledge scores at baseline, but a significant difference in post intervention knowledge scores (t = -15.05 p<0.001) WhatsApp can be a more effective tool for providing dental education on tobacco and oral cancer as compared to conventional audio-visual aids. 相似文献
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To monitor the activity of the humoral component in graft dysfunction following renal transplantation using live related donors, flowcytometric cross-match procedure was adopted. Antidonor antibodies were detected in the sera of both pre- and post-transplant patients using conventional serological cytotoxicity cross-match and flowcytometric cross-match assays. In the 52 pretransplant samples no significant differences were observed in flowcytometric and cytotoxicity tests except in 2 secondary transplant cases which were negative by cytotoxicity test. However, in post-transplant samples, floweytometry was found to be a more objective and useful test than cytotoxicity testing in distinguishing 6 out of 7 mild acute-graft-rejection episodes. Both tests were found to be negative in alt 5 cases of cyclosporin-A nephrotoxicity, 7 cases of acute tubular necrosis and 10 out of 11 cases of chronic rejection.KEY WORDS: Flowcytometry, Cross-match, Graft dysfunction, Kidney transplantation 相似文献
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Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups 总被引:12,自引:1,他引:12
Marron MP; Raffel LJ; Garchon HJ; Jacob CO; Serrano-Rios M; Martinez Larrad MT; Teng WP; Park Y; Zhang ZX; Goldstein DR; Tao YW; Beaurain G; Bach JF; Huang HS; Luo DF; Zeidler A; Rotter JI; Yang MC; Modilevsky T; Maclaren NK; She JX 《Human molecular genetics》1997,6(8):1275-1282
Linkage disequilibrium (association) analysis was used to evaluate a
candidate region near the CTLA4/CD28 genes using a multi-ethnic collection
of families with one or more children affected by IDDM. In the data set
unique to this study (Spanish, French, Mexican-American, Chinese and
Korean), the transmission/disequilibrium test (TDT) revealed a highly
significant deviation for transmission of alleles at the (AT)n
microsatellite marker in the 3' untranslated region (P = 0.002) and the A/G
polymorphism in the first exon (P = 0.00002) of the CTLA4 gene. The overall
evidence for transmission deviation of the CTLA4 A/G alleles is also highly
significant (P = 0.00005) in the combined data set (669 multiplex and 357
simplex families) from this study and a previous report on families from
USA, Italy, UK, Spain and Sardinia. Significant heterogeneity was observed
in these data sets. The British, Sardinian and Chinese data sets did not
show any deviation for the A/G polymorphism, while the Caucasian-American
data set showed a weak transmission deviation. Strong deviation for
transmission was seen in the three Mediterranean-European populations
(Italian, Spanish and French) (P = 10(-5)), the Mexican-American population
(P = 0.002) and the Korean population (P = 0.03). These results suggest
that a true IDDM susceptibility locus (designated IDDM12) is located near
CTLA4.
相似文献
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Namrata Rastogi Shivali Duggal Shailendra Kumar Singh Konica Porwal Vikas Kumar Srivastava Rakesh Maurya Madan L.B. Bhatt Durga Prasad Mishra 《Oncotarget》2015,6(41):43310-43325
Human papilloma virus (HPV) expressing E6 and E7 oncoproteins, is known to inactivate the tumor suppressor p53 through proteasomal degradation in cervical cancers. Therefore, use of small molecules for inhibition of proteasome function and induction of p53 reactivation is a promising strategy for induction of apoptosis in cervical cancer cells. The polyphenolic alkanone, 6-Gingerol (6G), present in the pungent extracts of ginger (Zingiber officinale Roscoe) has shown potent anti-tumorigenic and pro-apoptotic activities against a variety of cancers. In this study we explored the molecular mechanism of action of 6G in human cervical cancer cells in vitro and in vivo. 6G potently inhibited proliferation of the HPV positive cervical cancer cells. 6G was found to: (i) inhibit the chymotrypsin activity of proteasomes, (ii) induce reactivation of p53, (iii) increase levels of p21, (iv) induce DNA damage and G2/M cell cycle arrest, (v) alter expression levels of p53-associated apoptotic markers like, cleaved caspase-3 and PARP, and (vi) potentiate the cytotoxicity of cisplatin. 6G treatment induced significant reduction of tumor volume, tumor weight, proteasome inhibition and p53 accumulation in HeLa xenograft tumor cells in vivo. The 6G treatment was devoid of toxic effects as it did not affect body weights, hematological and osteogenic parameters. Taken together, our data underscores the therapeutic and chemosensitizing effects of 6G in the management and treatment of cervical cancer. 相似文献
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