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131.
132.
M R Nuwer E N Miller B R Visscher E Niedermeyer J W Packwood L G Carlson P Satz W Jankel J C McArthur 《Neurology》1992,42(6):1214-1219
We conducted EEG testing in 200 asymptomatic homosexual men, half of whom were HIV seropositive. We chose to include half of the subjects because they were rated as impaired on a neuropsychological screening test. We used both traditional visual EEG interpretation and quantitative EEG analysis. Abnormal EEGs and borderline degrees of EEG slowing occurred in 32% of these men. These EEG changes were not related to HIV serostatus. EEG changes did correlate with the impaired neuropsychological test performance. Clinicians faced with abnormal EEG results or borderline EEG slowing in an asymptomatic HIV-seropositive patient should not attribute the EEG change to effects of the serostatus itself but should look for other causes. 相似文献
133.
Neuronal Ca2+: getting it up and keeping it up. 总被引:1,自引:0,他引:1
R J Miller 《Trends in neurosciences》1992,15(9):317-319
134.
135.
David H. Miller M.D. Theodore T. Miller M.D. Elizabeth Schultz M.D. Baruch Toledano M.D. 《Emergency radiology》1997,4(3):172-176
We report a case of dislocation of the second through fifth carpometacarpal joints and review the mechanism of injury and radiographic findings in such injuries. 相似文献
136.
Dr. Seema A. Khan MD Nick J. Gonchoroff DrPH Linda E. Miller PhD 《Annals of surgical oncology》1997,4(6):462-469
Background: Many studies have addressed the effect of the timing of surgery for breast cancer relative to menstrual cycle phase, with
conflicting results. Explanations for the possibility that survival could be altered by the appropriate timing of breast cancer
surgery in humans remain speculative.
Methods: We examined the expression of three estrogen related proteins (c-erbB-2, cathepsin D, pS2) in the breast tumors from 69 premenopausal women sampled in different phases of the menstrual cycle.
Data on S-phase fraction and hormone receptor expression were also analyzed. Immunohistochemical assays were used to measure
the proteins of interest. S-phase fraction was determined by flow cytometry. Analyses were performed based on fraction of
cells staining positive for the protein, density of stain, and a histoscore that combined both fraction of positive cells
and density.
Results: We found no differences in c-erbB-2, cathepsin D, hormone receptor, or S-phase levels in tumors sampled in the follicular versus luteal phase, or perimenstrual
versus periovulatory phase. The exception was pS2, which was expressed at greater levels during the luteal than during the
follicular phase of the cycle (p<0.01); but there was no difference in pS2 expression when the patients were classified as
periovulatory versus perimenstrual.
Conclusions: Our findings do not support a variation in c-erbB-2, cathepsin D, S-phase fraction, or receptor expression as an explanation for the differences in breast cancer prognosis
when surgery is timed by menstrual cycle phase. The finding that pS2 (an indicator of hormone sensitivity, and possibly better
prognosis) is expressed at higher levels in tumor samples during the luteal phase suggests that the biologic profile of breast
tumors may vary with the menstrual cycle and that these variations deserve further study. 相似文献
137.
138.
A case of primary testicular carcinoid is presented in which extensive testing for peptide hormones was done. None was found suggesting that such tumors may be nonfunctional. A systematic approach to the evaluation and treatment of testicular carcinoid is presented. 相似文献
139.
140.
Chronic clonazepam administration decreases gamma-aminobutyric acidA receptor function in cultured cortical neurons 总被引:1,自引:0,他引:1
Chronic benzodiazepine administration has been reported to decrease gamma-aminobutyric acidA (GABAA) receptor function in animals and may alter benzodiazepine binding in neuronal cultures. To assess GABAA receptor function in neuronal cultures exposed to chronic clonazepam, we measured muscimol-stimulated chloride uptake in chick cerebral cortical cultures treated acutely and for 2, 4, and 10 days. Acute clonazepam administration (1 microM) led to an increase in GABA-related chloride uptake at lower doses of muscimol. After chronic clonazepam (1 microM), maximal uptake was markedly decreased at day 10, but maximal uptake was unchanged after 2- and 4-day treatments. Benzodiazepine receptor binding was decreased by approximately 60% after 10 days due to a decrease in receptor number. Decreases in chloride uptake were also observed after 10 days of treatment with 0.1 and 10 microM clonazepam. Concomitant treatment with 0.1 microM Ro15-1788 abrogated the effect of 0.1 microM clonazepam on chloride uptake. Chronic clonazepam treatment (1 microM) did not alter total cellular protein, cellular protein synthesis or degradation or percentage of neuronal cells, as determined morphologically and by [3H]ouabain binding. 相似文献