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排序方式: 共有668条查询结果,搜索用时 250 毫秒
661.
Camous Moslemi Susanne G. Sækmose Rune Larsen Jakob T. Bay Thorsten Brodersen Maria Didriksen Henrik Hjalgrim Karina Banasik Kaspar R. Nielsen Mie T. Bruun Joseph Dowsett Khoa M. Dinh Susan Mikkelsen Christina Mikkelsen Thomas F. Hansen Henrik Ullum Christian Erikstrup Søren Brunak Karen Angeliki Krogfelt Jill R. Storry Sisse R. Ostrowski Martin L. Olsson Ole B. Pedersen 《Transfusion》2023,63(12):2297-2310
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Louise Ørnskov Drechsler Jens Kjærgaard Boldsen Lotte Hindhede Bitten Aagaard Lene Holm Harritshøj Christina Mikkelsen Thorsten Brodersen Nanna Brøns Michael Schwinn Henrik Hjalgrim Klaus Rostgaard Mie Topholm Bruun Sisse Rye Ostrowski Ole Birger Pedersen Susan Mikkelsen Christian Erikstrup 《Transfusion》2023,63(9):1710-1718
Background
The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation-induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin-guided iron supplementation for female first-time donors implemented in four of five administrative regions in Denmark.Study Design and Methods
We included 45,919 female first-time donors in this study. Hb values were determined in donations of included donors during a 2-year follow-up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8 mmol/L ~ 12.5 g/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow-up period.Results
We observed a statistically significant decrease in the risk of female first-time donors experiencing a donation with low Hb after ferritin-guided iron supplementation was introduced: Odds ratio, 0.82; 95% confidence interval (CI), 0.71–0.95. We found a statistically significant increase in the number of donations per donor during the follow-up period after intervention; rate ratio: 1.05, 95% CI: 1.02–1.08.Discussion
Ferritin-guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first-time blood donors. The intervention was additionally associated with an increase in the number of donations per donor. 相似文献664.
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Mona Ameri Chalmer Lisette J. A. Kogelman Ida Callesen Charlotte Grønvold Christensen Tanya Ramdal Techlo Peter L. Møller Olafur B. Davidsson Isa A. Olofsson Michael Schwinn Susan Mikkelsen Khoa Manh Dinh Kaspar Nielsen Mie Topholm Christian Erikstrup Sisse Rye Ostrowski Ole Birger Pedersen DBDS Genomic Consortium Henrik Hjalgrim Karina Banasik Kristoffer S. Burgdorf Mette Nyegaard Jes Olesen Thomas Folkmann Hansen 《European journal of neurology》2023,30(6):1774-1784
Background and purpose
Understanding migraine in a sex-specific manner is crucial for improving clinical care, diagnosis and therapy for both females and males. Here, data on sex differences are provided in the presentation of migraine in a large European-based population cohort, which is representative of the general population.Methods
A population-based study of 62,672 Danish blood donors (both present and previous donors), of whom 12,658 had migraine, was performed. All participants completed a 105-item diagnostic migraine questionnaire sent via an electronic mailing system (e-Boks) between May 2020 and August 2020. The questionnaire allowed for correct diagnosis of migraine according to the International Classification of Headache Disorders, third edition.Results
The migraine questionnaire was in-cohort validated and had a positive predictive value of 97% for any migraine, a specificity of 93% and a sensitivity of 93%. There were 9184 females (mean age 45.1 years) and 3434 males (mean age 48.0 years). The 3-month prevalence of migraine without aura was 11% in females and 3.59% in males. The 3-month prevalence of migraine with aura was 1.72% in females and 1.58% in males. In females, the age-related 3-month prevalence of migraine without aura increased markedly during childbearing age. In males, migraine both with and without aura showed less age variation. Females had a higher frequency of migraine attacks (odds ratio [OR] 1.22) but a lower frequency of non-migraine headaches (OR = 0.35). Females also had a greater intensity of pain, more unilateral and pulsatile pain, and exacerbation by physical activity (OR = 1.40–1.49) as well as more associated symptoms (OR = 1.26–1.98). Females carried 79% of the total migraine disease burden, which was almost exclusively driven by migraine without aura (77%), whilst there was no sex difference in the disease burden of migraine with aura.Conclusion
Females have more severe disease, resulting in a much higher migraine disease burden than indicated by prevalence alone. 相似文献668.
Camous Moslemi Susanne Sækmose Rune Larsen Thorsten Brodersen Maria Didriksen Henrik Hjalgrim Karina Banasik Kaspar R. Nielsen Mie T. Bruun Joseph Dowsett Kathrine A. Kasperen Susan Mikkelsen Thomas F. Hansen Henrik Ullum Christian Erikstrup Martin L. Olsson Sisse R. Ostrowski Ole B. Pedersen 《Transfusion》2023,63(1):47-58