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61.
Norito Kokubun Nortina Shahrizaila Michiaki Koga Koichi Hirata Nobuhiro Yuki 《Clinical neurophysiology》2013,124(8):1671-1679
ObjectiveThe exclusive association of Campylobacter jejuni infection with the axonal variant of Guillain–Barré syndrome (GBS) is debatable. The current study aims to elucidate the GBS subtypes of patients with an antecedent C. jejuni infection.MethodsNerve conduction study results of 73 patients with GBS were reviewed. Patients were defined as having a recent C. jejuni infection when there was a positive stool culture or serological evidence of C. jejuni in the presence of preceding diarrhea.ResultsA total of 23 patients had evidence of a recent C. jejuni infection. At the early stage, patients were classified as AMAN (n = 9; 39%), AIDP (n = 3; 13%) or equivocal (n = 9) using existing electrophysiological criteria. Prolonged distal latencies and conduction slowing that were seen in 11 patients rapidly normalized within 3 weeks in seven, whereas four had minor abnormalities throughout the course. Subsequently, all patients showed either acute motor axonal neuropathy pattern or reversible conduction failure.ConclusionSerial neurophysiology suggests that C. jejuni infections are exclusive to axonal GBS.SignificanceOur findings suggest that AMAN can demonstrate the full complement of demyelinating features at the early stages of disease. 相似文献
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Miyamoto M Kotani K Okada K Fujii Y Konno K Ishibashi S Taniguchi N 《Acta diabetologica》2012,49(1):63-68
The clinical significance of the diameter of the common carotid artery (CCA) measured ultrasonographically in diabetic practice
has not been sufficiently established. The objective of this study was to investigate the relationship of the ultrasonic CCA
diameter with atherosclerotic measures and diabetic retinopathy as a microvascular complication in patients with type 2 diabetes
mellitus (T2DM). This hospital-based cross-sectional study included 102 patients with T2DM (men: 65%, mean age: 57 years)
who had no apparent carotid arterial stenosis and no history of cardiovascular or severe renal disease. The current smoking
status, body mass index, blood pressure, hemoglobin A1c, serum low-density lipoprotein cholesterol, and ultrasonic measures
of carotid arteries (CCA diameter, intima-media thickness (IMT), plaque score) were measured. The cardio-ankle vascular index
(CAVI) and the presence of diabetic retinopathy were also assessed. The CCA diameter showed a significant positive correlation
with the mean IMT or plaque score. The CAVI had a significant positive correlation with the mean IMT, plaque score, and CCA
diameter, while diabetic retinopathy had a significant positive correlation with the CCA diameter, but not the mean IMT or
plaque score. These results were unaltered after adjusting for multiple confounders. The CCA diameter may serve as a useful
marker for atherosclerosis and diabetic retinopathy, and in particular, may be a marker associated with diabetic retinopathy
more clearly than the carotid IMT and plaque score, in patients with T2DM. 相似文献
66.
Sato A Hiroe M Akiyama D Hikita H Nozato T Hoshi T Kimura T Wang Z Sakai S Imanaka-Yoshida K Yoshida T Aonuma K 《Journal of cardiac failure》2012,18(6):480-486
BackgroundTenascin-C (TN-C), an extracellular matrix glycoprotein, is not normally expressed in the adult heart but transiently reappears under various pathologic conditions to play important roles in tissue remodeling. It is unclear whether serum TN-C levels add prognostic information independent from traditional prognostic markers.Methods and ResultsWe assessed 239 patients with first ST-segment elevation myocardial infarction who underwent successful percutaneous coronary intervention. We measured serum TN-C and plasma B-type natriuretic peptide (BNP) levels on day 5 after admission and compared long-term clinical outcome. During the follow-up period (24.3 ± 13 months), 54 patients experienced primary composite cardiac events (cardiac death or hospitalization for worsening heart failure). Multivariable Cox proportional hazards analysis indicated that serum TN-C (hazard ratio 2.92, 95% confidence interval [CI] 1.55–5.67; P < .001) and plasma BNP levels (hazard ratio 1.84, 95% CI 1.17–2.97; P = .008) were significant independent predictors for cardiac events after adjustment for multiple confounders. The combination of TN-C and BNP resulted in an increase of the c-statistic from 0.821 to 0.877 (P < .001) and an integrated discrimination improvement gain of 14.0% (P < .001).ConclusionsSerum TN-C level on day 5 after admission is potentially useful for early risk stratification after AMI beyond established prognostic markers. 相似文献
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Chikashi Shibata Masayuki Kakyo Makoto Kinouchi Naoki Tanaka Koh Miura Takeshi Naitoh Hitoshi Ogawa Fuyuhiko Motoi Shinichi Egawa Tatsuya Ueno Hiroo Naito Michiaki Unno 《Surgery today》2013,43(11):1281-1285
Introduction
The glucagon provocative test is useful for the diagnosis of gastrinoma. The aim of this study was to determine the criteria for the glucagon provocative test.Methods
This study reviewed 8 patients that underwent the glucagon provocative test preoperatively and in whom the diagnosis was confirmed as gastrinoma histologically. The glucagon provocative test was performed by administering glucagon (20 μg/kg) intravenously, followed by 20 μg/kg h for the next 30 min, and plasma gastrin levels were measured 3 and 1 min before and 3, 5, 7, 10, 15, 20, and 30 min after the administration of glucagon. This study evaluated the peak value of plasma gastrin and the time required to reach the peak.Results
Two of the 8 patients had multiple endocrine neoplasm type 1. The basal plasma gastrin levels ranged from 524 to 10,300 pg/ml. The time required to reach the peak was 3–10 min for all patients. The increase in the peak from the basal value was 235–8,920 pg/ml, and the percentage of increase was 38–337 %.Conclusions
These results suggest that a diagnosis of gastrinoma should thus be made when plasma gastrin levels peak within 10 min after glucagon administration, with an increase of greater than 200 pg/ml and greater than 35 % of the basal value. 相似文献69.
Morikawa Takanori Ishida Masaharu Takadate Tatsuyuki Hata Tatsuo Iseki Masahiro Kawaguchi Kei Ohtsuka Hideo Mizuma Masamichi Hayashi Hiroki Nakagawa Kei Motoi Fuyuhiko Kamei Takashi Naitoh Takeshi Unno Michiaki 《Surgery today》2020,50(2):153-162
Surgery Today - We introduced a superior approach and a unique technique to retract the stomach, called the “stomach roll-up technique”, to standardize laparoscopic distal... 相似文献
70.
Yuan Ji Daniel J Schaid Zeruesenay Desta Michiaki Kubo Anthony J Batzler Karen Snyder Taisei Mushiroda Naoyuki Kamatani Evan Ogburn Daniel Hall-Flavin David Flockhart Yusuke Nakamura David A Mrazek Richard M Weinshilboum 《British journal of clinical pharmacology》2014,78(2):373-383