全文获取类型
收费全文 | 235412篇 |
免费 | 14888篇 |
国内免费 | 990篇 |
专业分类
耳鼻咽喉 | 2524篇 |
儿科学 | 5990篇 |
妇产科学 | 4417篇 |
基础医学 | 29319篇 |
口腔科学 | 4320篇 |
临床医学 | 24088篇 |
内科学 | 49631篇 |
皮肤病学 | 3221篇 |
神经病学 | 23682篇 |
特种医学 | 10131篇 |
外国民族医学 | 13篇 |
外科学 | 37085篇 |
综合类 | 2540篇 |
现状与发展 | 1篇 |
一般理论 | 177篇 |
预防医学 | 16559篇 |
眼科学 | 5529篇 |
药学 | 15485篇 |
1篇 | |
中国医学 | 319篇 |
肿瘤学 | 16258篇 |
出版年
2023年 | 1335篇 |
2022年 | 2194篇 |
2021年 | 5344篇 |
2020年 | 3050篇 |
2019年 | 5060篇 |
2018年 | 6056篇 |
2017年 | 4452篇 |
2016年 | 4854篇 |
2015年 | 5738篇 |
2014年 | 8363篇 |
2013年 | 11262篇 |
2012年 | 17310篇 |
2011年 | 18041篇 |
2010年 | 10077篇 |
2009年 | 9317篇 |
2008年 | 15871篇 |
2007年 | 16676篇 |
2006年 | 16203篇 |
2005年 | 16066篇 |
2004年 | 15110篇 |
2003年 | 13791篇 |
2002年 | 13194篇 |
2001年 | 1931篇 |
2000年 | 1435篇 |
1999年 | 2003篇 |
1998年 | 2785篇 |
1997年 | 2212篇 |
1996年 | 1922篇 |
1995年 | 1762篇 |
1994年 | 1527篇 |
1993年 | 1492篇 |
1992年 | 981篇 |
1991年 | 930篇 |
1990年 | 789篇 |
1989年 | 745篇 |
1988年 | 680篇 |
1987年 | 615篇 |
1986年 | 637篇 |
1985年 | 679篇 |
1984年 | 911篇 |
1983年 | 786篇 |
1982年 | 1035篇 |
1981年 | 964篇 |
1980年 | 837篇 |
1979年 | 464篇 |
1978年 | 514篇 |
1977年 | 448篇 |
1976年 | 421篇 |
1975年 | 314篇 |
1974年 | 311篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
62.
Quantitative autoradiographic analysis was used to identify regions in the brain of the male primate where androgen binding sites may be involved in the actions of testosterone. Three days after castration, adult male rhesus monkeys received a subcutaneous injection of either dihydrotestosterone propionate (DHTP, 20 mg, n = 6), testosterone propionate (TP, 100 mg, n = 2), or oil vehicle (control males, n = 4). Three hours later, 5 mCi [3H]testosterone was administered as an i.v. bolus. At 60 min, brains were rapidly removed and the left halves were used for autoradiography. In control males, highest percentages of labeled neurons (20-84% using a rigorous Poisson criterion) were observed in the ventromedial, arcuate and premammillary nuclei (n.) of the hypothalamus, medial preoptic n., bed n. of stria terminalis, intercalated mammillary n., lateral septal n. and the medial, cortical and accessory basal n. of the amygdala. Pretreatment with DHTP eliminated labeling in androgen target tissues of the genital tract, and reduced the percentages of labeled neurons to 4-22% of control values in the arcuate, lateral septal, premammillary and intercalated mammillary n., indicating that in these regions testosterone acted predominantly at androgen binding sites. However, in the medial preoptic n., the ventromedial hypothalamic n. and the accessory basal amygdaloid n., DHTP pretreatment resulted in much less blocking which, together with other data, suggested that in these sites, testosterone's actions involved aromatization and interaction with estrogen-binding sites. 相似文献
63.
64.
65.
Molecular determinants of cetuximab efficacy. 总被引:17,自引:0,他引:17
Daniel Vallb?hmer Wu Zhang Michael Gordon Dong Yun Yang Jim Yun Oliver A Press Katrin E Rhodes Andy E Sherrod Syma Iqbal Kathleen D Danenberg Susan Groshen Heinz-Josef Lenz 《Journal of clinical oncology》2005,23(15):3536-3544
PURPOSE: To investigate whether mRNA expression levels of cyclin D1 (CCND1), cyclooxygenase 2 (Cox-2), epidermal growth factor receptor (EGFR), interleukin 8 (IL-8), and vascular endothelial growth factor (VEGF), all members of the EGFR signaling pathway, are associated with clinical outcome in patients with EGFR-expressing metastatic colorectal cancer (CRC) treated with cetuximab. PATIENTS AND METHODS: Thirty-nine patients with metastatic CRC, refractory to both irinotecan and oxaliplatin, were enrolled on IMCL-0144 and treated with single-agent cetuximab. The intratumoral mRNA levels of CCND1, Cox-2, EGFR, IL-8, and VEGF were assessed from paraffin-embedded tissue samples using laser-capture microdissection and quantitative real-time polymerase chain reaction. RESULTS: There were 21 women and 18 men with a median age of 64 years (range, 35 to 83 years). Higher gene expression levels of VEGF were associated with resistance to cetuximab (P = .038; Kruskal-Wallis test). The combination of low gene expression levels of Cox-2, EGFR, and IL-8 was significantly associated with overall survival (13.5 v 2.3 months; P = .028; log-rank test). Both findings were independent of skin toxicity that was itself significantly correlated to survival. Patients with a lower mRNA amount of EGFR had a longer overall survival compared with patients that had a higher mRNA amount (7.3 v 2.2 months; P = .09; log-rank test). Patients with lower expression of Cox-2 had a significantly higher rate of grade 2 to 3 skin reactions under cetuximab treatment. CONCLUSION: This pilot study suggests that gene expression levels of Cox-2, EGFR, IL-8, and VEGF in patients with metastatic CRC may be useful markers of clinical outcome in single-agent cetuximab treatment. 相似文献
66.
67.
68.
Angelo Lipira David Limbrick Bruce Haughey Phillip Custer Michael R. Chicoine 《Skull base》2009,19(4):303-309
69.
70.
Heidi Ulrich Michael Landthaler Thomas Vogt 《Journal der Deutschen Dermatologischen Gesellschaft》2007,5(6):493-495
The induction of a granulomatous inflammation by jellyfish toxins is rare. More typically, acute toxic and urticarial reactions are seen. An 11-year-old boy developed a striated urticarial erythema on the left cheek after contact with a gelatinous mass while swimming in the sea in Croatia. After initial erosion, a striated induration developed in the area of contact. Histological examination revealed a granulomatous inflammation with some eosinophils. While topical steroid-based antiinflammatory and antibacterial therapy over several weeks was not effective, topical therapy with tacrolimus 0.1% for two two-week treatment periods led to healing of the skin changes with a slight scar. There was no clinical recurrence after 5 month of follow-up. 相似文献