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Cathrine Jonsson Marco Pagani Martin Ingvar Lennart Thurfjell Shahrohk Kimiaei Hans Jacobsson Stig A. Larsson 《European journal of nuclear medicine and molecular imaging》1998,25(2):157-165
Single-photon emission tomography (SPET), using technetium-99m hexamethylpropylene amine oxime, and positron emission tomography
(PET), using oxygen-15 butanol were compared in six healthy male volunteers with regard to the mapping of resting state regional
cerebral blood flow (rCBF). A computerized brain atlas was utilized for 3D regional analyses and comparison of 64 selected
and normalized volumes of interest (VOIs). The normalized mean rCBF values in SPET, as compared to PET, were higher in most
of the Brodmann areas in the frontal and parietal lobes (4.8% and 8.7% respectively). The average differences were small in
the temporal (2.3%) and occipital (1.1%) lobes. PET values were clearly higher in small VOIs like the thalamus (12.3%), hippocampus
(12.3%) and basal ganglia (9.9%). A resolution phantom study showed that the in-plane SPET/PET system resolution was 11.0/7.5 mm.
In conclusion, SPET and PET data demonstrated a fairly good agreement despite the superior spatial resolution of PET. The
differences between SPET and PET rCBF are mainly due to physiological and physical factors, the data processing, normalization
and co-registration methods. In order to further improve mapping of rCBF with SPET it is imperative not only to improve the
spatial resolution but also to apply accurate correction techniques for scatter, attenuation and non-linear extraction.
Received 3 August and in revised form 1 October 1997 相似文献