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101.
102.
Maxime Fastrez Jean Vandromme Pascale George Serge Rozenberg Michel Degueldre 《European journal of obstetrics, gynecology, and reproductive biology》2009,147(2):226-229
ObjectivesAdequate staging of advanced cervical cancer is essential in order to optimally treat the patient. FIGO clinical staging, imaging techniques such as CT scan, MRI and PET sometimes underestimate the extension of tumors. The presence of para-aortic lymph node metastases in advanced cervical cancer identifies patients with poor prognosis who need to be treated aggressively. Laparoscopic para-aortic lymph node dissection is now proposed as a diagnostic tool in many guidelines. We evaluated the feasibility and safety of a robot assisted laparoscopic transperitoneal approach to para-aortic lymph node dissection.Study designEight patients with advanced cervical carcinoma who were eligible for primary pelvic radiotherapy combined with concurrent cisplatin chemotherapy or pelvic exenteration underwent a pre-treatment robot assisted transperitoneal laparoscopic para-aortic lymphadenectomy.ResultsWe isolated from 1 to 38 para-aortic nodes per patient and had one para-aortic node positive patient who was treated with extended doses of pelvic radiotherapy. We did not encounter any major complications and post-operative morbidity was low.ConclusionsRobot assisted transperitoneal laparoscopic para-aortic lymphadenectomy is feasible and provides the surgeon with greater precision than classical laparoscopy. Larger prospective multicentric trials are needed to validate the generalised usefulness of this technique. 相似文献
103.
Denis Anson MS OTR Penni Moist OTR Mary Przywara OTR Heather Wells OTR Heather Saylor OTR Hantz Maxime OTR 《Assistive technology : the official journal of RESNA》2013,25(2):146-154
Word prediction is often recommended by therapists as a means to improve typing speed for clients with physical limitations. Although literature suggests that word prediction does have an effect on writing proficiency, increased speed is not one of its benefits when used with a standard keyboard. One reason given for the failure of word prediction to accelerate typing is that the user must look away from any source document to scan the prediction list during typing. Looking away from the source document may slow the typist more than any acceleration offered by word prediction. For input methods that already require the typist to look away from the copy, this effect might be irrelevant. The focus of this research was to determine whether word completion or word prediction programs would increase typing speed when used with an input method (an on-screen keyboard) that also requires looking away from the source document. Ten people, five men and five women, aged 20 to 38 years, participated in this study. The study used a single-subject, successive intervention design to test typing speed and accuracy using an on-screen keyboard with integrated word prediction software. Seven participants had their fastest typing speed with word prediction. Two participants had their fastest typing speed with word completion. Only one participant demonstrated no improvement in speed when using these two programs. Overall, these results show that the use of word prediction and word completion may assist on-screen keyboard users to improve typing speed. 相似文献
104.
105.
Athan Baillet Xavier Romand Arnaud Pflimlin Mickael Dalecky Pascal Claudepierre René-Marc Flipo Adeline Ruyssen-Witrand Philippe Gaudin Laure Gossec Anna Molto Cédric Lukas Sophie Pouplin Martin Soubrier Daniel Wendling Françoise Fayet Christophe Hudry Eric Senbel Marjorie Schwartz Maxime Dougados 《Revue du Rhumatisme》2021,88(2):86-92
106.
F. Germán Rodríguez-González Anieta M. Sieuwerts Marcel Smid Maxime P. Look Marion E. Meijer-van Gelder Vanja de Weerd Stefan Sleijfer John W. M. Martens John A. Foekens 《Breast cancer research and treatment》2011,127(1):43-51
MicroRNAs (miRNAs) are small RNA molecules that modulate gene expression and which have been implicated in cancer. We evaluated
whether five candidate predictive miRNAs, derived from a pilot study in which 249 miRNAs were assayed, were associated with
clinical benefit of tamoxifen therapy in advanced breast cancer. These five miRNAs were measured in an independent series
of 246 estrogen receptor (ER)-positive primary breast tumors of patients who received tamoxifen for advanced disease by quantitative
Real Time PCR. Univariate analysis showed that higher expression levels of hsa-miR-30a-3p, hsa-miR-30c, and hsa-miR-182 were
significantly associated with benefit of tamoxifen treatment and with longer PFS (all P-values <0.01). In multivariate analysis, corrected for the traditional predictive factors, only hsa-miRNA-30c was an independent
predictor (P-value <0.01). Finally, in an attempt to understand the biology connected to this miRNA, Global testing pathway analysis showed
an association of hsa-miRNA-30c expression with HER and RAC1 signaling pathways. We identified hsa-miRNA-30c as an independent
predictor for clinical benefit of tamoxifen therapy in patients with advanced breast cancer. Assessment of tumor levels and
connected pathways could be helpful to improve treatment strategies. 相似文献
107.
Association of an extracellular matrix gene cluster with breast cancer prognosis and endocrine therapy response 总被引:1,自引:0,他引:1
Jozien Helleman Maurice P H M Jansen Kirsten Ruigrok-Ritstier Iris L van Staveren Maxime P Look Marion E Meijer-van Gelder Anieta M Sieuwerts Jan G M Klijn Stefan Sleijfer John A Foekens Els M J J Berns 《Clinical cancer research》2008,14(17):5555-5564
PURPOSE: We previously discovered an extracellular matrix (ECM) gene cluster associated with resistance to first-line tamoxifen therapy of patients with metastatic breast cancer. In this study, we determined whether the six individual ECM genes [collagen 1A1 (COL1A1), fibronectin 1 (FN1), lysyl oxidase (LOX), secreted protein acidic cysteine-rich (SPARC), tissue inhibitor of metalloproteinase 3 (TIMP3), and tenascin C (TNC)] were associated with treatment response, prognosis, or both. EXPERIMENTAL DESIGN: In 1,286 primary breast tumors, mRNA expression (quantitative real-time PCR) was related to clinicopathologic factors and disease outcome in univariate and multivariate analysis including traditional factors. RESULTS: TIMP3, FN1, LOX, and SPARC expression levels (continuous variables) were significantly associated with distant metastasis-free survival (MFS) in 680 lymph node-negative untreated patients (P<0.03). Using a calculated linear prognostic score, these patients were evenly divided into five prognostic groups with a significant difference in 10-year MFS of approximately 40% between the two extreme prognostic groups. Furthermore, high TNC expression as continuous variable was associated with (a) shorter MFS in 139 estrogen receptor-positive and lymph node-positive patients who received adjuvant tamoxifen therapy (hazard ratio, 1.53; P=0.001), and (b) no clinical benefit (odds ratio, 0.81; P=0.035) and shorter progression-free survival (hazard ratio, 1.19; P=0.002) in 240 patients in whom recurrence was treated with tamoxifen as first-line monotherapy. These results were also significant in multivariate analyses. CONCLUSION: FN1, LOX, SPARC, and TIMP3 expression levels are associated with the prognosis of patients with breast cancers, whereas TNC is associated with resistance to tamoxifen therapy. Further validation and functional studies are necessary to determine the use of these ECM genes in decisions regarding treatment and whether they can serve as targets for therapy. 相似文献
108.
Of 18 children with monoclonal immunoglobulins in their sera, 13 had a primary or secondary immunodeficiency. The monoclonal immunoglobulin belonged to each of the three main Ig classes, and in 3 children multiple monoclonal components were detected. The level of the monoclonal component exceeded 0·5 g/100 ml in 7 cases. The monoclonal immunoglobulin disappeared spontaneously in 9 children. The significance of this homogeneous component and the importance of the underlying immunodeficiency are outlined. 相似文献
109.
An-Sofie Schoonjans Shauni De Keersmaecker Maxime Van Bouwel Berten Ceulemans 《European journal of paediatric neurology》2019,23(1):61-69
Aim
Sleep problems are often reported in patients with a Dravet Syndrome (DS). In this study we explored the sleep behavior in DS and compared the prevalence of sleep problems with other epilepsy patients.Methods
An online questionnaire based on the ‘Sleep Behavior Questionnaire by Simonds & Parraga (SQ-SP)’ was distributed amongst DS parents and a control group (parents from children with epilepsy). Completed questionnaires were evaluated by factor scores and Composite Sleep Index (CSI).Results
Fifty-six responses were recorded in the DS group (42 were ≤18 year). Caregivers reported an overall frequency of sleep problems in 42.3% (22/52). Severe sleep problems, measured by CSI, were found in 28.3% (13/46) mainly related to night waking or daytime sleepiness. In the control group (n = 66, 62 were ≤18 year), sleep problems were reported by 21.2% (14/52) of the parents. Comparison analysis between pediatric DS and epilepsy patients revealed no significant differences between the prevalence of different types of sleep disorders, except for daytime sleepiness (p = 0.042). However, the parent (or caregiver)-reported quality of sleep was significantly lower in the DS group (p = 0.011).Interpretation
Sleep problems are frequent in DS patients and are mainly related to daytime sleepiness and night waking. Compared with other epilepsy patients, severe sleep problems are not more common in patients with a DS. However DS patients tend to have more mild night waking problems, which may explain the worse parental-reported sleep quality in DS patients. 相似文献110.