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21.
Leila Laatikainen Jouko Mattila 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1996,234(1):67-68
Background: We wanted to evaluate whether intracameral injection of tissue plasminogen activator (tPA) is useful in managing traumatic hyphaema. Methods: Two eyes with total hyphaema after a severe penetrating injury were treated with a single intracameral injection of 25 g of tPA 5 and 14 days after the injury, respectively. Results: Most of the blood coagulum dissolved within 24 h, and in one of the two eyes the intraocular pressure decreased from 45 to 8 mmHg. The other eye was hypotonic. No re-bleeding or complications related to the use of tPA were noticed. Conclusion: The results in these two cases suggest that tPA is a useful adjunct in managing total hyphaema. 相似文献
22.
Abstract: We report the first case of fatal anthrax meningoencephalitis in Hong Kong over the past 60 years. A 13 year-old boy presented with right lower quadrant pain, diarrhoea and progressive headache. Lumbar puncture yielded gram positive bacilli initially thought to be Bacillus cereus, a contaminant. He was treated with ampicillin and cefotaxime, but died 3 days after hospitalization. The organism isolated from blood and cerebrospinal fluid was later identified as Bacillus anthracis. 相似文献
23.
A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma 总被引:8,自引:2,他引:8
Chen J; Giovannucci E; Hankinson SE; Ma J; Willett WC; Spiegelman D; Kelsey KT; Hunter DJ 《Carcinogenesis》1998,19(12):2129-2132
We examined the relationship between a functional polymorphism (667C--
>T, ala-->val) of the methylenetetrahydrofolate reductase gene
(MTHFR) and the risk of colorectal adenomas in the prospective Nurses'
Health Study. Among 257 incident polyp cases and 713 controls, the MTHFR
val/val polymorphism [relative risk (RR) = 1.35, 95% confidence interval
(CI) 0.84-2.17] was not significantly associated with risk of adenomas.
This lack of association was observed for both small (RR = 1.36, 95% CI
0.76-2.45) and large (RR = 1.32, 95% CI 0.66-2.66) adenomas. Furthermore,
there was no significant interaction between this polymorphism and
consumption of either folate, methionine or alcohol. We also examined the
relationship of a newly identified polymorphism (asp919gly) of the
methionine synthase gene (MS) with the risk of colorectal adenomas in the
same population. The MS gly/gly polymorphism was also not significantly
associated with risk of colorectal adenomas (RR = 0.66, 95% CI 0.26-1.70).
These results, which need to be confirmed in other studies, suggest that
the MTHFR val/val polymorphism, which has been previously inversely
associated with risk of colorectal cancer, plays a role only in a late
stage (adenoma-- >carcinoma) of colorectal tumorigenesis, and/or may
protect against malignant transformation in the subset of benign adenomas,
which may progress to malignancy.
相似文献
24.
背景和目的:罗格列酮与阿伐他汀联合疗法已经被证实对于2型糖尿病患者的血糖控制以及脂质水平都有益处。本试验将通过检测罗格列酮与阿伐他汀联合疗法对于2型糖尿病患者的生物标记水平的作用来研究该联合疗法对血管炎的作用。方法:30例患有2型糖尿病和高脂血症的患者被纳入治疗。对这些患者给予罗格列酮单一疗法4mg/d,持续3个月,然后在接下来的3个月中给予这些患者阿伐他汀10mg/d作为联合疗法。在研究开始时,罗格列酮单一疗法之后以及罗格列酮与阿伐他汀联合治疗之后测量炎性生物标记物,包括高敏C-反应蛋白(hs-CRP)、基质金属蛋白酶9(MMP… 相似文献
25.
Driving under light and dark conditions: effects of alcohol and diazepam in young and older subjects
Objectives: Driving at night time increases accident risk due to visual conditions, fatigue and impaired performance. In addition, the
use of alcohol and benzodiazepines may enhance the risks related to night-time driving. We studied these aspects of traffic
safety in a simulated driving test with young and older drivers.
Methods: In a double-blind, crossover, placebo-controlled study, nine young subjects, aged 22–24 years, performed simulated driving
in both `light' and `dark' conditions, before and 1.5 h and 4 h after 0.8 g · kg−1 ethanol (EOH) or 15 mg diazepam (DZ). Further, nine older subjects, aged 55–77 years, were similarly tested, but their EOH
dose was 0.7 g · kg−1 and the DZ dose was 10 mg. The tests were vigilance assessment on visual analogue scales (VAS), simulated driving under light
and dark conditions for 6 min each and digit symbol substitution (DSS).
Results: In the young subjects, both EOH and DZ similarly impaired DSS, with DZ causing more subjective drowsiness, clumsiness, mental
slowness and poor overall performance than EOH. During simulated driving, both EOH and DZ impaired simple and complex tracking
(EOH>DZ) and prolonged reaction times (EOH=DZ). Impairment of performance was practically identical under light and dark conditions.
In the older subjects, objective performance on DSS was poorer (−30%) than that of the young ones, and subjective impairment
was marginal. During simulated driving, the baseline levels of variables in older subjects showed definite impairment (errors
+100% to +500%) when compared with young subjects. Active drugs impaired several variables (EOH>DZ), but the statistical significances
were fewer than in young subjects. Increase in reaction errors reached statistical significance, especially while driving
in the dark. Otherwise the driving results in light and dark were not notably different.
Conclusion: Young subjects drew good baselines but were sensitive to EOH and DZ, whilst the older subjects showed poor baselines but
were less sensitive to EOH and DZ. Although the baseline driving and responses to treatments were different in young and older
subjects, their driving and psychomotor impairment were unaffected by light conditions.
Received: 10 November 1999 / Accepted in revised form: 25 April 2000 相似文献
26.
M. Linnoila M. J. Mattila P. Karhunen E. Nuotto T. Seppälä 《European journal of clinical pharmacology》1981,21(1):27-32
Summary The actions and interactions of alcohol (1.5 g/kg) and two stimulant peptides were investigated in healthy volunteers. Double blind and cross over studies in 8 subjects, at one-week intervals, revealed that ORG 2766 (5 or 20 mg i.m.) and particularly TRH (10 µg/kg i.v.) enhanced rather than antagonized alcohol-induced inebriation. The interactions were associated with elevated breath alcohol concentrations. Similar studies with 8 other subjects showed that peptides given in combination with a non-alcoholic drink tended to impair performance assessed as various psychophysiological variables. However, ORG 2766 5 mg was subjectively rated as producing a feeling of improved performance. 相似文献
27.
28.
29.
P Leinikki E Mattila J Koistinen J Leikola M L Kantanen H Brummer-Korvenkontio 《Scandinavian journal of infectious diseases》1989,21(5):515-519
5,287 serum samples from 2 different sources in Finland, people possibly at risk and healthy blood donors, were tested for the presence of HTLV-I antibodies. No positive cases were found. The result suggests that this virus is not endemic in Finland. 10 cases gave repeatedly a low positive value in the enzyme immune assay (EIA) test but were confirmed negative with other tests that included western blot, passive agglutination and immunofluorescence. Four of these samples originated from healthy blood donors, 6 from other categories. Several of them showed restricted reactivity in western blots. Five HIV-positive sera, discovered during the study from people with possible risk factors, were also tested for HTLV-I but showed no reactivity. 相似文献
30.
Epidermal growth factor in human urine from birth to puberty 总被引:1,自引:0,他引:1
A L Mattila J Perheentupa K Pesonen L Viinikka 《The Journal of clinical endocrinology and metabolism》1985,61(5):997-1000
The highest concentrations of epidermal growth factor (EGF) are found in urine, but the physiological role of urinary EGF is unknown. We studied human urinary EGF excretion, by measuring its concentration with a specific homologous RIA, in 265 healthy children from birth until age 16 yr. The absolute concentrations varied widely between individuals. Mean values were approximately 10 ng/ml in 1- to 30-day-old infants; 2.5-fold higher values were found in infants aged 2 to 12 months. During the second year there was a further rise to about 70 ng/ml, and urinary EGF excretion was in the same range in older subjects. The EGF/creatinine concentration ratio was less variable. The mean ratio increased 6-fold from birth to the second year of life. Thereafter, the EGF/creatinine ratio decreased gradually to one-third of the peak level at puberty. No sex difference was found. 相似文献