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排序方式: 共有1126条查询结果,搜索用时 15 毫秒
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G. Teufel A. Albrecht G. Bastert P. Drings G. Geier K. Goerttler H. -J. Hohorst M. Kaufmann M. Klekow R. Kreienberg F. Kubli J. Mattern F. Melchert J. Neuhoeffer A. Pfleiderer H. Schmidt-Matthiesen R. Schumann G. Segeth G. Trams I. Vog-Moykopf M. Volm K. Wayss E. Weber E. Wüst 《Archives of gynecology and obstetrics》1981,232(1-4):258-259
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We compare the effects of 5-fluorouracil and N'-(2'-furanidyl)-5-fluorouracil (Ftorafur) in vivo (tumor size) and in vitro ([6-3H]-deoxyuridine incorporation) on solid Walker carcinosarcoma of the rat. 5-Fluorouracil and Ftorafur have a dose-dependent effect on tumor size and on [6-3H]-deoxyuridine incorporation in vitro. The in vivo effects on tumor size are similar when the dose of Ftorafur calculated by its molecular weight is about 3 times higher than that of 5-fluorouracil. In vitro an about 650 times higher dose of Ftorafur is required to achieve a comparable reduction of [6-3H]-deoxyuridine incorporation in the tumor cells. 相似文献
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S N Reske I Heck J Kropp H Mattern R Ledda R Knopp C Winkler 《Heart (British Cardiac Society)》1985,54(4):415-419
The effect of captopril mediated afterload reduction on aortic regurgitation was investigated in 10 patients. Regurgitation was quantitated by means of the regurgitation fraction and the relation of regurgitant volume to end diastolic volume. These variables were derived from gated radionuclide ventriculography. After captopril treatment the blood concentration of angiotensin I rose whereas that of angiotensin II fell significantly. The conversion of angiotensin I to II was reduced to about 50% of the control value. Whereas blood pressure and heart rate did not change significantly, the regurgitation fraction and the regurgitant volume, normalised to end diastolic volume, were significantly reduced by captopril treatment. The ejection fraction remained essentially unchanged. These findings suggest that captopril reduces aortic regurgitation by reducing afterload. 相似文献
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Use of radionuclide imaging in the early diagnosis and treatment of renal allograft rejection. 下载免费PDF全文
Data are presented on the clinical application of radionuclide imaging to evaluate changes in cadaver transplant function in the immediate postoperative period. The method uses orthoiodohippuric acid (hippuran) administered IV, with scintillation imaging, and curve analysis by a digital computer. An initial study is always obtained 24 hours after transplantation. Serial studies are then obtained, as needed, to interpret the clinical course. Selected cases are presented which illustrate the use of this protocol in various clinical settings. In the oliguric patient serial studies have been of particular value. They have identified ATN so that over-enthusiastic treatment for rejection could be avoided. They have also identified acute rejection complicating ATN so that high dose steroid therapy could be administered appropriately. In the non-oliguric patient they have frequently contributed to the early diagnosis of acute rejection, and they have been useful in monitoring the effect and duration of treatment for severe rejection crisis. It is concluded that radionuclide imaging studies, when carefully applied and interpreted, are a valuable adjunct to the management of patients in this complex clinical setting. 相似文献
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The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore 总被引:3,自引:0,他引:3
Stevenson CS Capper EA Roshak AK Marquez B Eichman C Jackson JR Mattern M Gerwick WH Jacobs RS Marshall LA 《The Journal of pharmacology and experimental therapeutics》2002,303(2):858-866
Marine natural products provide a rich source of chemical diversity that can be used to design and develop new, potentially useful therapeutic agents. We report here that scytonemin, a pigment isolated from cyanobacteria, is the first described small molecule inhibitor of human polo-like kinase, a serine/threonine kinase that plays an integral role in regulating the G(2)/M transition in the cell cycle. Scytonemin inhibited polo-like kinase 1 activity in a concentration-dependent manner with an IC(50) of 2 microM against the recombinant enzyme. Biochemical analysis showed that scytonemin reduced GST-polo-like kinase 1 activity in a time-independent fashion, suggesting reversibility, and with a mixed-competition mechanism with respect to ATP. Although scytonemin was less potent against protein kinase A and Tie2, a tyrosine kinase, it did inhibit other cell cycle-regulatory kinases like Myt1, checkpoint kinase 1, cyclin-dependent kinase 1/cyclin B, and protein kinase Cbeta2 with IC(50) values similar to that seen for polo-like kinase 1. Consistent with these effects, scytonemin effectively attenuated, without chemical toxicity, the growth factor- or mitogen-induced proliferation of three cell types commonly implicated in inflammatory hyperproliferation. Similarly, scytonemin (up to 10 microM) was not cytotoxic to nonproliferating endotoxin-stimulated human monocytes. In addition, Jurkat T cells treated with scytonemin were induced to undergo apoptosis in a non-cell cycle-dependent manner consistent with its activities on multiple kinases. Here we propose that scytonemin's dimeric structure, unique among natural products, may be a valuable template for the development of more potent and selective kinase inhibitors used for the treatment of hyperproliferative disorders. 相似文献
79.
Protein expression profile of primary human squamous cell lung carcinomas indicative of the incidence of metastases 总被引:2,自引:0,他引:2
The purpose of this investigation was to evaluate firstly whether different protein expression patterns exist in primary squamous
cell lung carcinomas of patients with and without lymph node involvement and secondly, whether or not different patterns exist
in tumours with positive lymph nodes. For this reason, formalin-fixed, paraffin-embedded specimens from 130 patients with
squamous cell lung carcinomas were analyzed by immunohistochemistry. In a first step, proteins were selected which showed
a relationship to lymph node involvement. The expression of JUN, ERBB2, MYC, cyclin D, PCNA, bFGF, VEGF and Hsp70 proteins
revealed a positive correlation to lymph node involvement. In contrast, caspase-3, Fas ligand, Fas/CD95, and PAI showed an
inverse correlation to lymph node involvement. In a second step, these parameters were further analyzed by hierarchical cluster
analyses. The resulting clusters were correlated to patients with or without lymph node involvement. The data show that different
protein expression patterns exist between primary squamous cell lung carcinomas with and without lymph node involvement and
within carcinomas with lymph node involvement. The data suggest that various metastasis profiles exist.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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