全文获取类型
收费全文 | 6919篇 |
免费 | 434篇 |
国内免费 | 98篇 |
专业分类
耳鼻咽喉 | 88篇 |
儿科学 | 104篇 |
妇产科学 | 130篇 |
基础医学 | 720篇 |
口腔科学 | 267篇 |
临床医学 | 573篇 |
内科学 | 2193篇 |
皮肤病学 | 85篇 |
神经病学 | 595篇 |
特种医学 | 247篇 |
外科学 | 1165篇 |
综合类 | 14篇 |
一般理论 | 1篇 |
预防医学 | 277篇 |
眼科学 | 68篇 |
药学 | 328篇 |
中国医学 | 6篇 |
肿瘤学 | 590篇 |
出版年
2024年 | 14篇 |
2023年 | 137篇 |
2022年 | 260篇 |
2021年 | 472篇 |
2020年 | 274篇 |
2019年 | 312篇 |
2018年 | 346篇 |
2017年 | 243篇 |
2016年 | 287篇 |
2015年 | 301篇 |
2014年 | 388篇 |
2013年 | 427篇 |
2012年 | 609篇 |
2011年 | 533篇 |
2010年 | 297篇 |
2009年 | 291篇 |
2008年 | 394篇 |
2007年 | 359篇 |
2006年 | 326篇 |
2005年 | 262篇 |
2004年 | 207篇 |
2003年 | 174篇 |
2002年 | 131篇 |
2001年 | 41篇 |
2000年 | 33篇 |
1999年 | 30篇 |
1998年 | 28篇 |
1997年 | 14篇 |
1996年 | 17篇 |
1995年 | 16篇 |
1994年 | 13篇 |
1992年 | 11篇 |
1991年 | 12篇 |
1990年 | 13篇 |
1989年 | 19篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 11篇 |
1985年 | 11篇 |
1979年 | 8篇 |
1978年 | 9篇 |
1977年 | 8篇 |
1976年 | 5篇 |
1974年 | 13篇 |
1973年 | 6篇 |
1972年 | 7篇 |
1971年 | 8篇 |
1970年 | 8篇 |
1969年 | 7篇 |
1966年 | 5篇 |
排序方式: 共有7451条查询结果,搜索用时 31 毫秒
81.
Matteo Martini Elia Valentini Salvatore Maria Aglioti 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2013,225(2):237-245
Observing models displaying facial expressions of pain elicits neural activity in onlookers’ neural structures involved in first-hand experience of pain and in monitoring conflicting information. We investigated whether the purported conflict between the pain and its emotional expression in a model modulates cortical responses elicited by nociceptive laser stimuli in an onlooker. Seeing happy facial expressions, incongruent with the perceptual status attributed to the model, determined a significant reduction in the laser-evoked N2 potential. One of the main sources of this response is the anterior cingulate cortex, an area involved in pain perception, empathy for pain and conflict detection. A pre-activation of the anterior cingulate cortex due to the detection of the emotional conflict may, therefore, be responsible for the reduction of nociceptive-related response in the same brain area. Thus, top–down variables, like the appraisal of the others’ emotional status, modulate onlookers’ nociceptive-related neural activity. 相似文献
82.
Pasquale Palmiero M.D. Maria Maiello M.D. David D. Daly Jr. M.D. Marco Matteo Ciccone M.D. Navin C. Nanda M.D. 《Echocardiography (Mount Kisco, N.Y.)》2012,29(10):1233-1238
Objective: The first goal of our study was to investigate major determinants of aortic stiffness in postmenopausal women using an echocardiographic method to calculate global pulse wave velocity (PWVg) rather than the less accurate carotid–femoral pulse wave velocity (PWVc). The second goal was to relate PWVg to the absolute risk of major cardiovascular (CV) events estimated by CV risk factors. Patients and methods: Two hundred forty‐four consecutive women who presented to our heart station were screened. One hundred twenty‐two were postmenopausal, either natural or surgical, whereas 122 were premenopausal. The mean age of the patients was 54 ± 13 years. Individuals were categorized as current smokers, former smokers, or nonsmokers and hypertensive or not. Hypercholesterolemia and diabetes mellitus were defined. Aortic stiffness was assessed by PWVg measured with pulsed Doppler, the interval between the beginning of QRS complex and the foot of the systolic upstroke in the Doppler spectral envelope was calculated at the aortic valve site and at the right common femoral artery. PWVg was calculated between the aortic valve and right common femoral artery by dividing the straight line distance between the two by the transit time. Results: There was a highly significant statistical difference (P < 0.0012) in PWVg between menstruating women and postmenopausal women. Similarly, this difference in PWVg was also noted among the menstruating population (P < 0.0014) when comparing normotensive women and hypertensive women. In postmenopausal women, PWVg was 6.8 m/sec in normotensive women and 7.56 m/sec in hypertensive women (P < 0.007). Conclusion: PWVg was increased in postmenopausal women compared with menstruating women. Systemic hypertension has an independent, but additive effect on aortic stiffness assessed by PWVg. Our study supports the usefulness of the assessment of aortic stiffness as a marker of CV disease and to identify subjects at risk at an early age. 相似文献
83.
An overview on children's wheelchair positioning in France. A French team working in a special center has made a clinical approach and gives their conclusions. 相似文献
84.
85.
86.
High rate of hematological responses to sorafenib in FLT3‐ITD acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplantation
下载免费PDF全文
![点击此处可从《European journal of haematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Tiago De Freitas Sarah Marktel Simona Piemontese Matteo G. Carrabba Cristina Tresoldi Carlo Messina Maria Teresa Lupo Stanghellini Andrea Assanelli Consuelo Corti Massimo Bernardi Jacopo Peccatori Luca Vago Fabio Ciceri 《European journal of haematology》2016,96(6):629-636
Relapse represents the most significant cause of failure of allogeneic hematopoietic stem cell transplantation (HSCT) for FLT3‐ITD‐positive acute myeloid leukemia (AML), and available therapies are largely unsatisfactory. In this study, we retrospectively collected data on the off‐label use of the tyrosine kinase inhibitor sorafenib, either alone or in association with hypomethylating agents and adoptive immunotherapy, in 13 patients with post‐transplantation FLT3‐ITD‐positive AML relapses. Hematological response was documented in 12 of 13 patients (92%), and five of 13 (38%) achieved complete bone marrow remission. Treatment was overall manageable in the outpatient setting, although all patients experienced significant adverse events, especially severe cytopenias (requiring a donor stem cell boost in five patients) and typical hand‐foot syndrome. None of the patients developed graft‐vs.‐host disease following sorafenib alone, whereas this was frequently observed when this was given in association with donor T‐cell infusions. Six patients are alive and in remission at the last follow‐up, and four could be bridged to a second allogeneic HSCT, configuring a 65 ± 14% overall survival at 100 d from relapse. Taken together, our data suggest that sorafenib might represent a valid treatment option for patients with FLT3‐ITD‐positive post‐transplantation relapses, manageable also in combination with other therapeutic strategies. 相似文献
87.
Cataldo Patruno M.D. Ph.D. Massimiliano Scalvenzi M.D. Matteo Megna M.D. Irene Russo M.D. Francesca Gaudiello M.D. Ph.D. Nicola Balato M.D. 《Pediatric dermatology》2014,31(1):38-42
The objective was to estimate the prevalence of melanocytic nevi (MN) in children and to determine their dermoscopic characteristics and relationship with anatomic location and environmental and constitutional factors. The population was a randomly selected sample of 144 children who attended primary schools in Naples, Italy. Before physical examination of the children, standardized interviews were conducted with their parents. Follow‐up interviews of both the children and parents were conducted 1 year later. Photographic and dermoscopic images were obtained. Boys had more MN than girls; 465 MN (55.6%) were observed in boys and 371 (44.4%) in girls (p < 0.05). The trunk and neck were the most common locations of MN (p < 0.001). The main dermoscopic feature of all MN observed was a globular pattern (p < 0.001). A significant correlation between duration of sunbathing and MN counts was revealed (p < 0.05). At 1‐year follow‐up, 118 new MN were identified in 66 children. The trunk and neck areas were the most common regions involved in the appearance of new MN (n = 68, 57.6% of all new MN, p < 0.001). The new MN count was significantly higher in children who reported more sunbathing (p < 0.001). Changes in the dermoscopic pattern were observed in 45 persistent MN, demonstrating more MN with a reticular‐globular pattern, especially on the trunk, neck, and upper extremities (p < 0.001). MN development in early life is the result of complicated relationships between nevus evolution, anatomic location, and environmental and constitutional factors. 相似文献
88.
Joseph Yun Kwong Kan Kitchai Rungcharassaeng Matteo Deflorian Tommaso Weinstein Hom‐Lay Wang Tiziano Testori 《Periodontology 2000》2018,77(1):197-212
An inevitable loss of soft and hard tissue after tooth extraction often results in a compromised site for anterior implant esthetics in both vertical and horizontal dimensions. Immediate implant placement and provisionalization has been a viable option for replacing failing maxillary anterior teeth as it preserves the vertical existing osseous and gingival architecture. With the simultaneous addition of soft‐ and hard‐tissue grafts, the peri‐implant horizontal tissue topography can also be maintained. The esthetic success of immediate implant placement and provisionalization procedures is influenced by a number of factors that can be identified as patient‐dependent or clinician‐dependent. This article describes in detail the process of patient selection, indications, contraindications, diagnosis, treatment planning and treatment execution required to achieve functional and esthetic success with immediate implant placement and provisionalization. 相似文献
89.
90.
Matteo Morotti Christos E. Zois Rokaya El-Ansari Madeleine L. Craze Emad A. Rakha Shih-Jung Fan Alessandro Valli Syed Haider Deborah C. I. Goberdhan Andrew R. Green Adrian L. Harris 《British journal of cancer》2021,124(2):494
Background Glutamine (Gln) is an abundant nutrient used by cancer cells. Breast cancers cells and particularly triple-receptor negative breast cancer (TNBC) are reported to be dependent on Gln to produce the energy required for survival and proliferation. Despite intense research on the role of the intracellular Gln pathway, few reports have focussed on Gln transporters in breast cancer and TNBC.Methods The role and localisation of the Gln transporter SLC38A2/SNAT2 in response to Gln deprivation or pharmacological stresses was examined in a panel of breast cancer cell lines. Subsequently, the effect of SLC38A2 knockdown in Gln-sensitive cell lines was analysed. The prognostic value of SLC38A2 in a cohort of breast cancer was determined by immunohistochemistry.Results SLC38A2 was identified as a strongly expressed amino acid transporter in six breast cancer cell lines. We confirmed an autophagic route of degradation for SLC38A2. SLC38A2 knockdown decreased Gln consumption, inhibited cell growth, induced autophagy and led to ROS production in a subgroup of Gln-sensitive cell lines. High expression of SLC38A2 protein was associated with poor breast cancer specific survival in a large cohort of patients (p = 0.004), particularly in TNBC (p = 0.02).Conclusions These results position SLC38A2 as a selective target for inhibiting growth of Gln-dependent breast cancer cell lines.Subject terms: Breast cancer, Cancer metabolism 相似文献