全文获取类型
收费全文 | 4993篇 |
免费 | 383篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 187篇 |
妇产科学 | 186篇 |
基础医学 | 647篇 |
口腔科学 | 220篇 |
临床医学 | 526篇 |
内科学 | 1084篇 |
皮肤病学 | 204篇 |
神经病学 | 334篇 |
特种医学 | 130篇 |
外科学 | 440篇 |
综合类 | 90篇 |
一般理论 | 7篇 |
预防医学 | 457篇 |
眼科学 | 90篇 |
药学 | 376篇 |
中国医学 | 56篇 |
肿瘤学 | 344篇 |
出版年
2024年 | 10篇 |
2023年 | 111篇 |
2022年 | 212篇 |
2021年 | 339篇 |
2020年 | 222篇 |
2019年 | 346篇 |
2018年 | 376篇 |
2017年 | 241篇 |
2016年 | 238篇 |
2015年 | 238篇 |
2014年 | 290篇 |
2013年 | 320篇 |
2012年 | 491篇 |
2011年 | 430篇 |
2010年 | 197篇 |
2009年 | 157篇 |
2008年 | 220篇 |
2007年 | 207篇 |
2006年 | 177篇 |
2005年 | 133篇 |
2004年 | 108篇 |
2003年 | 73篇 |
2002年 | 81篇 |
2001年 | 22篇 |
2000年 | 22篇 |
1999年 | 21篇 |
1998年 | 7篇 |
1997年 | 7篇 |
1996年 | 5篇 |
1995年 | 4篇 |
1993年 | 6篇 |
1992年 | 7篇 |
1991年 | 3篇 |
1990年 | 7篇 |
1989年 | 10篇 |
1988年 | 8篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 9篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 8篇 |
1973年 | 3篇 |
1970年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有5408条查询结果,搜索用时 15 毫秒
31.
Tanya M Tekautz Christine E Fuller Susan Blaney Maryam Fouladi Alberto Broniscer Thomas E Merchant Matthew Krasin James Dalton Gregory Hale Larry E Kun Dana Wallace Richard J Gilbertson Amar Gajjar 《Journal of clinical oncology》2005,23(7):1491-1499
PURPOSE: To describe clinical features, therapeutic approaches, and prognostic factors in pediatric patients with atypical teratoid/rhabdoid tumors (ATRT) treated at St Jude Children's Research Hospital (SJCRH). PATIENTS AND METHODS: Primary tumor samples from patients diagnosed with ATRT at SJCRH between July 1984 and June 2003 were identified. Pathology review included histologic, immunohistochemical analysis, and fluorescence in situ hybridization for SMARCB1 (also known as hSNF5/INI1) deletion. Clinical records of patients with pathologic confirmation of ATRT were reviewed. RESULTS: Thirty-seven patients were diagnosed with ATRT at SJCRH during the 19-year study interval. Six patients were excluded from this clinical review based on pathologic or clinical criteria. Of the remaining 31 patients, 22 were younger than 3 years. Posterior fossa primary lesions and metastatic disease at diagnosis were more common in younger patients with ATRT. All patients underwent surgical resection; 30 received subsequent chemotherapy. The majority of patients aged 3 years or older received postoperative craniospinal radiation. Two-year event-free (EFS) and overall survival (OS) of children aged 3 years or older (EFS, 78% + 14%; OS, 89% +/- 11%) were significantly better than those for younger patients (EFS, 11% +/- 6%; OS, 17% +/- 8%); EFS, P = .009 and OS, P = .0001. No other clinical characteristics were predictive of survival. Three of four patients 3 years or older with progressive disease were successfully rescued with ifosfamide, carboplatin, and etoposide therapy. CONCLUSION: Children presenting with ATRT before the age of 3 years have a dismal prognosis. ATRT presenting in older patients can be cured using a combination of radiation and high-dose alkylating therapy. Older patients with relapsed ATRT can have salvage treatment using ICE chemotherapy. 相似文献
32.
33.
34.
Sarumathi Gobinathan Siti Solehah Zainol Siti Fatmah Azizi Nabil Mohamad Iman Rajasegaran Muniandy Hanis Nazihah Hasmad 《Journal of biomaterials science. Polymer edition》2013,24(17):2051-2067
AbstractAmniotic membrane has the potential to be used as scaffold in various tissue engineering applications. However, increasing its biostability at the same time maintaining its biocompatibility is important to enhance its usage as a scaffold. This studied characteristics genipin-crosslinked amniotic membrane as a bioscaffold. Redundant human amniotic membranes (HAM) divided into native (nAM), decellularized (dAM) and genipin-crosslinked (clAM) groups. The dAM and clAM group were decellularized using thermolysin (TL) and sodium hydroxide (NaOH) solution. Next, clAM group was crosslinked with 0.5% and 1.0% (w/v) genipin. The HAM was then studied for in vitro degradation, percentage of swelling, optical clarity, ultrastructure and mechanical strength. Meanwhile, fibroblasts isolated from nasal turbinates were then seeded onto nAM, dAM and clAM for biocompatibility studies. clAM had the slowest degradation rate and were still morphologically intact after 30 days of incubation in 0.01% collagenase type 1 solution. The dAM had a significantly highest percentage of swelling than other groups (p?<?0.05). Besides, the dAM retained the collagen content at similar level of nAM. Although the dAM had highest mechanical strength compared to the rest of the groups, the differences were statistically insignificant. Cell attachment on dAM and 0.5% clAM was higher compared to that on nAM and 1.0% clAM. In conclusion, clAM have better biostability and biocompatibility compared to the nAM and dAM. Together with other suitable characteristics of the clAM such as percentage of swelling, structural integrity and ECM content, clAM is suitable as scaffold for various tissue engineering applications. 相似文献
35.
Jose R. Gonzalez‐Porras Fernando Escalante Emilia Pardal Magdalena Sierra Luis J. Garcia‐Frade Santiago Redondo Maryam Arefi Carlos Aguilar Fernando Ortega Erik de Cabo Rosa M. Fisac Oscar Sanz Carmen Esteban Ignacio Alberca Mercedes Sanchez‐Barba Maria T. Santos Abel Fernandez Tomas J. Gonzalez‐Lopez representing the Grupo de Trombosis y Hemostasia de Castilla y León 《European journal of haematology》2013,91(3):236-241
36.
Geir Bjørklund Nagwa A. Meguid Afaf El-Ansary Mona A. El-Bana Maryam Dadar Jan Aaseth Maha Hemimi Joško Osredkar Salvatore Chirumbolo 《Journal of molecular neuroscience : MN》2018,66(4):492-511
Autism spectrum disorder (ASD) is a neurodevelopmental disorder afflicting about one in every 68 children. It is behaviorally diagnosed based on a triad of symptoms, including impairment in communication, impairment in sociability and abnormal and stereotypic behavior. The subjectivity of behavioral diagnosis urges the need for clinical biomarker tests to improve and complement ASD diagnosis and treatment. Over the past two decades, researchers garnered a broad range of biomarkers associated with ASD and often correlating with the severity of ASD, which includes metabolic and genetic biomarkers or neuroimaging abnormalities. Metabolic biomarkers are either involved in key pathways such as a trans-sulfuration pathway or produced due to the derangement of these pathways in the case of oxidative stress. Recent studies reported several genetic abnormalities related to ASD, encompassing various mechanisms, from copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) to chromosomal anomalies. However, it is still premature to consider these genetic variants as true biomarkers for ASD, due to their low reproducibility and regional-specific nature. Herein, we comprehensively review state of the art about major biomarkers reported in ASD and the association of some biomarkers with ASD symptoms and severity. It is important to establish those biomarkers to be able to help in the diagnosis and to optimize the treatment of ASD. 相似文献
37.
The Interactive Whiteboard (IWB) is now a common technological artefact in Swedish preschools and schools. This study examines preschool teachers’ thinking behind the embedding of IWB in the early years’ mathematics classroom and how preschool teachers structure their mathematical activities when using IWB. Two complementary empirical studies, that is, interviews and video observations, were conducted with four preschool teachers. The findings demonstrate that (just) having a positive attitude to technological artefacts like IWB is less likely to enrich the learning environment and lead to pedagogical change. This suggests that teachers’ IWB use is mostly informed by their pedagogical knowledge. 相似文献
38.
39.
Maryam Esmaeili Martin Berry Ann Logan Zubair Ahmed 《中国神经再生研究》2014,9(18):1653-1656
The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory mole- cules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Dec orin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenu- ates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system. 相似文献
40.