首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   995篇
  免费   63篇
耳鼻咽喉   15篇
儿科学   20篇
妇产科学   19篇
基础医学   115篇
口腔科学   25篇
临床医学   86篇
内科学   139篇
皮肤病学   8篇
神经病学   147篇
特种医学   30篇
外科学   135篇
综合类   2篇
一般理论   3篇
预防医学   54篇
眼科学   8篇
药学   56篇
肿瘤学   196篇
  2021年   4篇
  2020年   4篇
  2019年   9篇
  2018年   13篇
  2017年   12篇
  2016年   12篇
  2015年   12篇
  2014年   15篇
  2013年   26篇
  2012年   43篇
  2011年   38篇
  2010年   16篇
  2009年   21篇
  2008年   47篇
  2007年   36篇
  2006年   44篇
  2005年   42篇
  2004年   34篇
  2003年   37篇
  2002年   31篇
  2001年   30篇
  2000年   29篇
  1999年   41篇
  1998年   15篇
  1997年   19篇
  1996年   12篇
  1995年   20篇
  1994年   16篇
  1993年   11篇
  1992年   32篇
  1991年   28篇
  1990年   24篇
  1989年   32篇
  1988年   33篇
  1987年   18篇
  1986年   17篇
  1985年   26篇
  1984年   20篇
  1983年   10篇
  1982年   21篇
  1981年   6篇
  1980年   7篇
  1979年   17篇
  1978年   12篇
  1977年   12篇
  1976年   6篇
  1975年   12篇
  1974年   9篇
  1973年   7篇
  1971年   6篇
排序方式: 共有1058条查询结果,搜索用时 0 毫秒
31.
32.
33.
34.
Type D personality has been shown to increase the risk for cardiovascular events in patients with coronary artery disease (CAD). We investigated the effects of expanded cardiac rehabilitation on type D score and psychosocial characteristics in 224 CAD patients randomised to either expanded cardiac rehabilitation (stress management, increased physical training, stay at a “Patient Hotel” after discharge and cooking sessions), or routine rehabilitation. Follow-up was 1 year. At baseline patients with a high type D score [patients in the upper quartile of type D score (Q4) i.e., type D patients] had a lower sense of coherence (p < 0.001), a lower quality of life (p < 0.001), more depressive symptoms (p < 0.001) and increased anxiety (p < 0.001) as compared to patients with a low type D score (Q1). During follow-up, type D patients (Q4) randomised to intervention had significant decrements in type D-score (p < 0.01), depression and anxiety (p < 0.05) and an increment in quality of life scores (p < 0.001). Quality of life was also improved in control type D patients (Q4; p < 0.01) but no significant changes were seen in type D score, depression or anxiety. Expanded cardiac rehabilitation reduces type D score, anxiety and depressive symptoms, and improves the quality of life in type D patients.  相似文献   
35.
36.
37.
38.
39.
BACKGROUND AND PURPOSE: To evaluate the efficacy and safety of boron neutron capture therapy (BNCT) for glioblastoma multiforme (GBM) using a novel protocol for the boronophenylalanine-fructose (BPA-F) infusion. PATIENT AND METHODS: This phase II study included 30 patients, 26-69 years old, with a good performance status of which 27 have undergone debulking surgery. BPA-F (900mg BPA/kg body weight) was given i.v. over 6h. Neutron irradiation started 2h after the completion of the infusion. Follow-up reports were monitored by an independent clinical research institute. RESULTS: The boron-blood concentration during irradiation was 15.2-33.7mug/g. The average weighted absorbed dose to normal brain was 3.2-6.1Gy (W). The minimum dose to the tumour volume ranged from 15.4 to 54.3Gy (W). Seven patients suffered from seizures, 8 from skin/mucous problem, 5 patients were stricken by thromboembolism and 4 from abdominal disturbances in close relation to BNCT. Four patients displayed 9 episodes of grade 3-4 events (WHO). At the time for follow-up, minimum ten months, 23 out of the 29 evaluable patients were dead. The median time from BNCT treatment to tumour progression was 5.8 months and the median survival time after BNCT was 14.2 months. Following progression, 13 patients were given temozolomide, two patients were re-irradiated, and two were re-operated. Patients treated with temozolomide lived considerably longer (17.7 vs. 11.6 months). The quality of life analysis demonstrated a progressive deterioration after BNCT. CONCLUSION: Although, the efficacy of BNCT in the present protocol seems to be comparable with conventional radiotherapy and the treatment time is shorter, the observed side effects and the requirement of complex infrastructure and higher resources emphasize the need of further phase I and II studies, especially directed to improve the accumulation of (10)B in tumour cells.  相似文献   
40.

Background  

There is at present a lack of knowledge of time trends in health related quality of life (HRQL) in common patients with coronary artery disease (CAD) treated in ordinary care. The objective of this study is to assess and compare time trends of health related quality of life (HRQL) and chest pain in patients with coronary artery disease.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号