全文获取类型
| 收费全文 | 399篇 |
| 免费 | 30篇 |
| 国内免费 | 1篇 |
专业分类
| 耳鼻咽喉 | 7篇 |
| 儿科学 | 3篇 |
| 妇产科学 | 9篇 |
| 基础医学 | 79篇 |
| 口腔科学 | 21篇 |
| 临床医学 | 18篇 |
| 内科学 | 115篇 |
| 皮肤病学 | 7篇 |
| 神经病学 | 49篇 |
| 特种医学 | 2篇 |
| 外科学 | 26篇 |
| 综合类 | 3篇 |
| 预防医学 | 38篇 |
| 眼科学 | 4篇 |
| 药学 | 42篇 |
| 中国医学 | 2篇 |
| 肿瘤学 | 5篇 |
出版年
| 2023年 | 2篇 |
| 2022年 | 6篇 |
| 2021年 | 12篇 |
| 2020年 | 5篇 |
| 2019年 | 13篇 |
| 2018年 | 17篇 |
| 2017年 | 5篇 |
| 2016年 | 14篇 |
| 2015年 | 16篇 |
| 2014年 | 13篇 |
| 2013年 | 21篇 |
| 2012年 | 31篇 |
| 2011年 | 25篇 |
| 2010年 | 15篇 |
| 2009年 | 7篇 |
| 2008年 | 12篇 |
| 2007年 | 18篇 |
| 2006年 | 14篇 |
| 2005年 | 17篇 |
| 2004年 | 18篇 |
| 2003年 | 24篇 |
| 2002年 | 14篇 |
| 2001年 | 12篇 |
| 2000年 | 16篇 |
| 1999年 | 9篇 |
| 1998年 | 6篇 |
| 1997年 | 7篇 |
| 1996年 | 2篇 |
| 1995年 | 4篇 |
| 1994年 | 4篇 |
| 1993年 | 3篇 |
| 1992年 | 5篇 |
| 1991年 | 8篇 |
| 1990年 | 2篇 |
| 1989年 | 2篇 |
| 1988年 | 6篇 |
| 1986年 | 3篇 |
| 1985年 | 2篇 |
| 1984年 | 3篇 |
| 1979年 | 2篇 |
| 1978年 | 1篇 |
| 1977年 | 1篇 |
| 1976年 | 2篇 |
| 1975年 | 1篇 |
| 1974年 | 2篇 |
| 1973年 | 2篇 |
| 1972年 | 2篇 |
| 1971年 | 1篇 |
| 1967年 | 1篇 |
| 1964年 | 1篇 |
排序方式： 共有430条查询结果，搜索用时 797 毫秒
91.
Liliana Reis Luís Paiva Marco Costa Joana Silva Rogério Teixeira Ana Botelho Paulo Dinis Marta Madeira Joana Ribeiro José Nascimento Lino Gonçalves 《Revista portuguesa de cardiologia》2018,37(9):763-772
Introduction
Percutaneous closure of the left atrial appendage (LAA) is a promising therapy in patients with atrial fibrillation with high risk for stroke and contraindication for oral anticoagulation (OAC). Intracardiac echocardiography (ICE) may make this percutaneous procedure feasible in patients in whom transesophageal echocardiography (TEE) is inadvisable. Our aim was to assess the efficacy and safety of LAA closure and the feasibility of ICE compared to TEE to guide the procedure.Methods
In this cohort study of patients who underwent LAA closure between May 2010 and January 2017, clinical and imaging assessment was performed before and after the procedure.Results
In 82 patients (mean age 74±8 years, 64.4% male) the contraindications for OAC were severe bleeding or anemia (65%), high bleeding risk (14%), labile INR (16%), or recurrent embolic events (5%). The procedural success rate was 96.3%. The procedure was guided by TEE or ICE, and no statistically significant differences were observed between the two techniques. During follow‐up, one patient had an ischemic stroke at 12 months, two had bleeding complications at six months, and there were four non‐cardiovascular deaths. Embolic and bleeding events were less frequent than expected from the observed CHA2DS2VASc (0.6% vs. 6.3%; p<0.001) and HAS‐BLED (1.2% vs. 4.1%; p<0.001) risk scores.Conclusions
In this population percutaneous LAA closure was shown to be safe and effective given the lower frequency of events than estimated by the CHA2DS2VASc and HAS‐BLED scores. The clinical and imaging results of procedures guided by ICE in the left atrium were not inferior to those guided by TEE. 相似文献92.
Nuno Cardim Dulce Brito Luís Rocha Lopes António Freitas Carla Araújo Adriana Belo Lino Gonçalves Jorge Mimoso Iacopo Olivotto Perry Elliott Hugo Madeira 《Revista portuguesa de cardiologia》2018,37(1):1-10
Introduction
We report the results of the Portuguese Registry of Hypertrophic Cardiomyopathy, an initiative that reflects the current spectrum of cardiology centers throughout the territory of Portugal.Methods
A direct invitation to participate was sent to cardiology departments. Baseline and outcome data were collected.Results
A total of 29 centers participated and 1042 patients were recruited. Four centers recruited 49% of the patients, of whom 59% were male, and mean age at diagnosis was 53±16 years. Hypertrophic cardiomyopathy (HCM) was identified as familial in 33%. The major reason for diagnosis was symptoms (53%). HCM was obstructive in 35% of cases and genetic testing was performed in 51%. Invasive septal reduction therapy was offered to 8% (23% of obstructive patients). Most patients (84%) had an estimated five-year risk of sudden death of <6%. Thirteen percent received an implantable cardioverter-defibrillator. After a median follow-up of 3.3 years (interquartile range [P25-P75] 1.3-6.5 years), 31% were asymptomatic. All-cause mortality was 1.19%/year and cardiovascular mortality 0.65%/year. The incidence of heart failure-related death was 0.25%/year, of sudden cardiac death 0.22%/year and of stroke-related death 0.04%/year. Heart failure-related death plus heart transplantation occurred in 0.27%/year and sudden cardiac death plus equivalents occurred in 0.53%/year.Conclusions
Contemporary HCM in Portugal is characterized by relatively advanced age at diagnosis, and a high proportion of invasive treatment of obstructive forms. Long-term mortality is low; heart failure is the most common cause of death followed by sudden cardiac death. However, the burden of morbidity remains considerable, emphasizing the need for disease-specific treatments that impact the natural history of the disease. 相似文献93.
The EuroHeart Failure Survey programme--a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment. 总被引：10，自引：0，他引：10
94.
Barcelos Filipe Martins Catarina Madeira Nathalie Ângelo-Dias Miguel Cardigos Joana Alves Nuno Vaz-Patto José Cunha-Branco Jaime Borrego Luís-Miguel 《Clinical rheumatology》2021,40(7):2791-2804
Clinical Rheumatology - Sjögren’s syndrome (SjS) patients exhibit great phenotypical heterogeneity, reinforced by the positiveness of anti-SSA antibody. We aimed to evaluate lymphocyte... 相似文献
95.
Noelle V. Pavlovic Tania Randell Tim Madeira Steven Hsu Radoslav Zinoviev Martha Abshire 《Heart & lung : the journal of critical care》2019,48(2):90-104
Background
Left ventricular assist devices (LVADs) improve quality of life in end-stage heart failure but can cause serious complications such as infections with driveline infection causing significant morbidity and mortality.Objectives
The purpose of this systematic literature review is to synthesize the literature to determine variables associated with driveline infection and seek opportunities to improve nursing management of LVAD drivelines.Methods
A systematic literature review was performed. The evidence was synthesized using the Johns Hopkins Nursing Evidence-Based Practice tools and the Chain of Infection epidemiological framework.Results
Thirty-four studies focused on vulnerable host, portal of entry, and causative organism aspects of the Chain of Infection. Increased BMI, younger age, exposed driveline velour showed increased risk of infection and driveline dressing protocol change showed lower risk of infection.Conclusions
Although some risk factors for infection were identified, evidence is still limited. Nurses are uniquely positioned to improve driveline management, disrupting the chain of infection. 相似文献96.
97.
98.
R.M.C. Romanelli W.T. Clemente S.S.S. Lima E.M. Rezende G.H. Martinho L.F.R. Paiva F.A.C. Neves J.G.C. Madeira G.C.S. Amâncio A.S. Lima L.C. Faria R.L. Coutinho 《The Brazilian journal of infectious diseases》2010,14(1):54-59
Methicillin-resistant Staphylococcus aureus (MRSA) infections frequently complicate the post-operative course of transplant recipients, and despite nasal carriage and endemic colonization, MRSA outbreaks are not commonly described. This study reports a case of MRSA outbreak and discusses infection control measures and recommendations for this situation. 相似文献
99.
100.
The objective of this study is to understand what it means to a mother to have a child with a heart disease. In order to do so, a phenomenological approach was used. The study was carried out with mothers of children with congenital cyanotic cardiopathy at the Infant Cardiology Center of a public hospital in Campo Grande, State of Mato Grosso do Sul. Ten open interviews were made based on the following guiding question: What does it mean to you to have a child with a heart disease? The comprehensive analysis of the reported speeches made possible the construction of three categories: "Discovering the disease: being up against the unknown"; "Living together with cardiopathy: being with the child in the disease", and "Believing in a stronger force: the necessary support". The impact of the disease on the mother begins the moment the child is born. Desperation, guilt and insecurity are mentioned as present feelings. It is in God, however, that such mothers look for the necessary support to follow this new path--a path of pain and faith. 相似文献