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81.
Daniela N Schulz Eline S Smit Nicola E Stanczyk Stef PJ Kremers Hein de Vries Silvia MAA Evers 《Journal of medical Internet research》2014,16(3)
Background
Different studies have reported the effectiveness of Web-based computer-tailored lifestyle interventions, but economic evaluations of these interventions are scarce.Objective
The objective was to assess the cost-effectiveness and cost-utility of a sequential and a simultaneous Web-based computer-tailored lifestyle intervention for adults compared to a control group.Methods
The economic evaluation, conducted from a societal perspective, was part of a 2-year randomized controlled trial including 3 study groups. All groups received personalized health risk appraisals based on the guidelines for physical activity, fruit intake, vegetable intake, alcohol consumption, and smoking. Additionally, respondents in the sequential condition received personal advice about one lifestyle behavior in the first year and a second behavior in the second year; respondents in the simultaneous condition received personal advice about all unhealthy behaviors in both years. During a period of 24 months, health care use, medication use, absenteeism from work, and quality of life (EQ-5D-3L) were assessed every 3 months using Web-based questionnaires. Demographics were assessed at baseline, and lifestyle behaviors were assessed at both baseline and after 24 months. Cost-effectiveness and cost-utility analyses were performed based on the outcome measures lifestyle factor (the number of guidelines respondents adhered to) and quality of life, respectively. We accounted for uncertainty by using bootstrapping techniques and sensitivity analyses.Results
A total of 1733 respondents were included in the analyses. From a willingness to pay of €4594 per additional guideline met, the sequential intervention (n=552) was likely to be the most cost-effective, whereas from a willingness to pay of €10,850, the simultaneous intervention (n=517) was likely to be most cost-effective. The control condition (n=664) appeared to be preferred with regard to quality of life.Conclusions
Both the sequential and the simultaneous lifestyle interventions were likely to be cost-effective when it concerned the lifestyle factor, whereas the control condition was when it concerned quality of life. However, there is no accepted cutoff point for the willingness to pay per gain in lifestyle behaviors, making it impossible to draw firm conclusions. Further economic evaluations of lifestyle interventions are needed.Trial Registration
Dutch Trial Register NTR2168; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2168 (Archived by WebCite at http://www.webcitation.org/6MbUqttYB). 相似文献82.
83.
Wendy Lim Paula Holinski PJ Devereaux Andrea Tkaczyk Ellen McDonald France Clarke Ismael Qushmaq Irene Terrenato Holger Schunemann Mark Crowther Deborah Cook 《Critical care (London, England)》2008,12(2):R36-10
Introduction
To use screening cardiac troponin (cTn) measurements and electrocardiograms (ECGs) to determine the incidence of elevated cTn and of myocardial infarction (MI) in patients admitted to the intensive care unit (ICU), and to assess whether these findings influence prognosis. This is a prospective screening study.Materials and methods
We enrolled consecutive patients admitted to a general medical-surgical ICU over two months. All patients underwent systematic screening with cTn measurements and ECGs on ICU admission, then daily for the first week in ICU, alternate days for up to one month and weekly thereafter until ICU death or discharge, for a maximum of two months. Patients without these investigations ordered during routine clinical care underwent screening for study purposes but these results were unavailable to the ICU team. After the study, all ECGs were interpreted independently in duplicate for ischaemic changes meeting ESC/ACC criteria supporting a diagnosis of MI. Patients were classified as having MI (elevated cTn and ECG evidence supporting diagnosis of MI), elevated cTn only (no ECG evidence supporting diagnosis of MI), or no cTn elevation.Results
One hundred and three patients were admitted to the ICU on 112 occasions. Overall, 37 patients (35.9 per cent) had an MI, 15 patients (14.6 per cent) had an elevated cTn only and 51 patients (49.5 per cent) had no cTn elevation. Patients with MI had longer duration of mechanical ventilation (p < 0.0001), longer ICU stay (p = 0.001), higher ICU mortality (p < 0.0001) and higher hospital mortality (p < 0.0001) compared with those with no cTn elevation. Patients with elevated cTn had higher hospital mortality (p = 0.001) than patients without cTn elevation. Elevated cTn was associated with increased hospital mortality (odds ratio 27.3, 95 per cent CI 1.7 – 449.4), after adjusting for APACHE II score, MI and advanced life support. The ICU team diagnosed 18 patients (17.5 per cent) as having MI on clinical grounds; four of these patients did not have MI by adjudication. Thus, screening detected an additional 23 MIs not diagnosed in practice, reflecting 62.2 per cent of MIs ultimately diagnosed. Patients with MI diagnosed by the ICU team had similar outcomes to patients with MI detected by screening alone.Conclusion
Systematic screening detected elevated cTn measurements and MI in more patients than were found in routine practice. Elevated cTn was an independent predictor of hospital mortality. Further research is needed to evaluate whether screening and subsequent treatment of these patients reduces mortality. 相似文献84.
C.H. Smith Z.K. Jabbar‐Lopez Z.Z. Yiu T. Bale A.D. Burden L.C. Coates M. Cruickshank T. Hadoke E. MacMahon R. Murphy C. Nelson‐Piercy C.M. Owen R. Parslew E. Peleva E. Pottinger E.J. Samarasekera J. Stoddart C. Strudwicke V. A. Venning R.B. Warren L.S. Exton M.F. Mohd Mustapa 《The British journal of dermatology》2017,177(3):628-636
85.
中国心力衰竭流行病学调查及其患病率 总被引:289,自引:1,他引:289
目的 了解我国成年人慢性心力衰竭 (心衰 )的患病率和分布特征。方法 中国心血管健康多中心合作研究应用四阶段整群随机抽样方法 ,在全国 1 0个省市 (南方和北方各 5个省市 )抽取具有代表性的样本 ,年龄在 35~ 74岁之间 ,城市和农村各半 ,男、女人数均衡。统计不同年龄组、不同性别和不同地区人群的心衰患病率。结果 共抽样调查 35~ 74岁城乡居民 1 5 51 8人 ,心衰患病率为0 9% ;其中男性为 0 7% ,女性为 1 0 % ,女性患病率高于男性 (P <0 0 5)。 35~ 44岁、45~ 54岁、55~64岁、65~ 74岁年龄组的心衰患病率分别为 0 4%、1 0 %、1 3 %和 1 3 % ;随着年龄增高 ,心衰的患病率显著上升 (P <0 0 1 )。我国北方地区心衰患病率为 1 4% ,南方地区心衰患病率为 0 5 % ,北方明显高于南方 (P <0 0 1 ) ;城市人群心衰患病率为 1 1 % ,农村人群心衰患病率为 0 8% ,城市人群心衰患病率高于农村。结论 心衰正在成为我国心血管病领域的重要公共卫生问题 相似文献
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90.
Accurate pregnancy dating is vital to obstetric management. However, first trimester fetal charts commonly used in Australia rely on data reported more than three decades ago. This study reports first trimester dating and growth charts for crown‐rump length between 5 and 14 weeks of gestation and biparietal diameter between 9 and 14 weeks of gestation on an Australia population using modern real‐time ultrasound equipment. All consenting eligible women attending a large Sydney clinic for first trimester ultrasound between March 2005 and December 2006 were recruited. Measurements were carried out to Australasian Society for Ultrasound in Medicine standard protocols. Statistical analyses were undertaken using polynomial regression models and thorough diagnostic checks made. Overall 396 eligible women consented to the study, with 268 between 9 and 14 weeks of gestation. The average participant age was 34 years (range 22–45 years), 371 and all yielded valid biometry measurements. Equations, means and 90% reference intervals for crown‐rump length measurements and biparietal diameter measurements were derived using polynomial regression models. Thorough residual and diagnostic checks were made. Once validated by others, we believe they will warrant consideration for use by Australasian Society for Ultrasound in Medicine. 相似文献