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111.
The methods for treatment of advanced prostate cancer, based on the agonistic analogs of LH-RH were reviewed. New therapeutic approaches utilizing antagonistic analogs of LH-RH such as SB-75 (Cetrorelix) have been described. Analogs of LH-RH chemically linked to various cytotoxic radicals are also being developed. Combinations of LH-RH agonists or antagonists with superactive somatostatin analogues such as Octastatin (RC-160) or with bombesin/GRP antagonists are being investigated in order to delay or prevent the relapse and improve the therapy for prostate cancer. 相似文献
112.
113.
NB Sánchez IF Canedo PE García-Patos P de Unamuno Pérez AV Benito AM Pascual 《Journal of the European Academy of Dermatology and Venereology》2004,18(6):731-735
The association between vasculitis and cancer has been widely reviewed in recent decades. The existence of malignancies in patients with vasculitis has been estimated at about 4.5-8%, haematological neoplasms being the most frequently observed. The haematological malignancies most frequently described are lymphoproliferative diseases such as hairy cell leukaemia and lymphomas. On the contrary, the incidence of paraneoplastic vasculitis in patients with myeloma is low; up to now, we have found nine cases reported on this subject. We report the case of a 73-year-old woman who in 1 year showed three outbreaks of acutely painful, purpuric and ulceronecrotic lesions, localized on the lower extremities. Histopathological study demonstrated thrombosis in the arterioles and leucocytoclastic vasculitis. Complementary tests revealed the presence of multiple myeloma. 相似文献
114.
Wang GJ; Volkow ND; Roque CT; Cestaro VL; Hitzemann RJ; Cantos EL; Levy AV; Dhawan AP 《Radiology》1993,186(1):59
115.
Lung torsion: case report and literature review 总被引:1,自引:0,他引:1
A 65-year-old woman with endobronchial carcinoma had torsion of the left upper lobe. A posteroanterior chest radiograph showed apparent atelectasis in the left upper lobe, but the lateral view disclosed an inappropriate posterior displacement of the collapsed lobe. The vasculature of the affected area showed an unusual curvature. Review of 21 examples of lung torsion disclosed no characteristic age, sex, or affected lobe. The most common associations were with previous surgery (n = 10) or a history of trauma (n = 5). The most common radiographic findings are opacification of the affected lobe (n = 12), an abnormal vascular pattern (n = 6), and an abnormal location for the atelectatic lung (n = 5). Affected lobes often show hemorrhagic infarction or necrosis. 相似文献
116.
Mach bands and density perception 总被引:1,自引:0,他引:1
117.
AK Martusevich AA Grishina AV Bochkareva 《Asian Pacific journal of tropical medicine》2010,3(3):176-179
ObjectiveTo investigate the teziocrystalloscopic features of urine which were collected from both healthy rodents and those with parasitosis.MethodsPhysical-chemical characteristics of urine samples that were collected from 15 mice and 20 rats were estimated by their ability to crystallize. Crystallization test results were interpreted with integrated identity table which includes 5 main classes of the crystalline and amorphous formations. Additional quantitative and semiquantitative evaluation indicators were also used.ResultsPresence of Trichinella spiralis in animal organism transformed results of the biofluid free crystallogenesis. The main components of rats' urine facia were single-crystalline rectangles which were made of cholesterol and its derivatives. The biofluid microsamples of healthy rats and rats with echinococcosis had both common and difference.ConclusionsUrine teziocrystalloscopic analysis is an informative method for diagnosis of helminthiasis in animals. 相似文献
118.
Granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), gamma-interferon (gamma-IFN), or tumor necrosis factor-alpha (TNF-alpha) triggered the rapid, stable phosphorylation of a 75-Kd protein (p75) when incubated with permeabilized HL60 human myeloid leukemia cells in the presence of [gamma-32P] ATP. Among several chemical inducers of HL60 cell differentiation, dimethyl sulfoxide also triggered p75 labeling, but retinoic acid or 12-O-tetradecanoylphorbol-13-acetate did not elicit this response. Pretreatment of cells with G-CSF or GM-CSF for more than 30 seconds before permeabilization rendered the p75 labeling undetectable, suggesting that ligand-stimulated labeling was rapidly completed within this time in intact cells. Phosphorylation of p75 occurred on serine and tyrosine residues. This conclusion was confirmed by direct phosphoamino acid analysis. Immunoblot analysis of lysates of intact HL60 cells that had been incubated with G-CSF, GM-CSF, IFN, or TNF confirmed that tyrosine phosphorylation of a p75 also occurred in response to these cytokines in intact cells. Pretreatment of intact HL60 cells with one biologic agent or dimethyl sulfoxide abolished p75 labeling in response to incubation of permeabilized cells with a second agent, strongly suggesting that the same protein was phosphorylated in response to these treatments. p75 labeling was strictly dependent on expression of the appropriate ligand receptor. Data suggest that activation of a tyrosine kinase system is an early response to the binding of G-CSF, GM-CSF, TNF, or IFN to their respective cell surface receptors, or to the addition of dimethyl sulfoxide, and that the resulting phosphorylation event(s) may play a role in securing common elements in the biologic responses to these agents. 相似文献
119.
The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5- deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)- transformed lymphocytes from normal subjects and patients with patients with pernicious anemia. Uptake and conversion were much greater by PHA- stimulated lymphocytes than by mature non-transformed lymphocytes. In normal cells, uptake of 57Co-CN-Cbl and synthesis of the cobalamin coenzymes were approximately linear between 3 and 48 hr incubation. Ado- Cbl was the major cobalamin formed, and after 72 hr the cells contained about twice as much Ado-Cbl as Me-Cbl. Uptake by lymphocytes from patients with untreated pernicious anemia (PA) was greater than that by normal lymphocytes, but the proportions of Ado-Cbl and Me-Cbl synthesized by each were similar. Folic acid and methyltetrahydrofolate enhanced synthesis of Me-Cbl both in normal and in PA cells, while methotrexate and 5-fluorouracil depressed it. This depression was overcome by 5-formyltetrahydrofolate, suggesting that an uninterrupted folate cycle may play an important role in Me-Cbl synthesis. 相似文献
120.
Of 423 posteroanterior chest radiographs in patients aged 21-66 years, 12.8% showed a homogeneous oval opacity with unsharp margins at the right apex and 16.8% at the left apex. Anatomy of the vessel, observations in patients with pneumothorax or atherosclerotic calcification, and fluoroscopic and computed tomographic evidence lead to the conclusion that the apical opacity is produced by the subclavian artery. 相似文献