［5－（4－甲脒－苄基）－2，4－二氧代－咪唑烷－3－基］－乙酰基－L－天冬氨酰－L－缬氨酸的合成

根据由精氨酸－甘氨酸－天冬氨酸组成的肽能抑制血小板聚集的机制，设计并合成了［５－（４－甲脒－苄基）－２，４－二氧代－咪唑烷－３－基］－乙酰基－Ｌ－天冬氨酰－Ｌ－缬氨酸（９）。生物试验结果表明：（９）抑制血小板聚集作用最强，其活性以ＩＣ＿（５０）值相比，强于类似物。     

肝素治疗小儿肾病综合征的远期效应

采用无抗凝作用剂量肝素皮下注射治疗小儿肾病综合征２５例，观察了近期疗效与１２～２４月后对皮质激素或环磷酰胺（ＣＴＸ）治疗反应的关系．结果表明，近期对肝素治疗显效但复发以及有效者，今后用激素或ＣＴＸ治疗均可达完全缓解，无效者则效果较差．本文结果表明，肝素治疗的近期疗效可用于预测肾病患儿的远期预后．     

核黄素等抗甲基苄基亚硝胺的致细胞突变作用

采用ＣＨＯ细胞ＨＧＰＲＴ位点突变测定系统观察了核黄素、尼克酰胺和锌等微量营养素对甲基苄基亚硝胺（ＭＢＮＡ）致细胞突变作用的影响。结果表明，在ＲＰＭＩ１６４０培养基中添加核黄素（２．６～１３．０μｍｏｌ／Ｌ）或尼克酰胺（４０～１２０μｍｏｌ／Ｌ）可显著抑制ＭＢＮＡ的致细胞突变作用。联合应用核黄素、尼克酰胺和锌效果更佳。提示：核黄素等微量营养素可能具有阻止细胞癌变的作用，为应用微量营养素干预治疗癌变过程提供了一定的理论依据。     

手术治疗胫腓骨远端骨折36例

目的 :探讨胫腓骨远端骨折治疗术式的选择、术中术后应注意的问题及其疗效。方法 :对不同类型的胫腓骨远端骨折 36例进行 8～ 18个月的随访 ,并结合临床及影像学资料 ,对其诊断、手术方法及治疗效果进行分析总结。结果 :本组术后 2 5～ 3 5个月骨折均愈合。踝关节功能优良率 77 7%。结论 :熟悉骨折的分型及相应内固定术式的选择 ;注重踝穴骨折的解剖复位及固定和踝关节的功能位固定及早期功能锻炼。     

Optimizing Suicide Gene Therapy for Head and Neck Cancer

An effective “suicide gene” therapy strategy in experimental studies has been the use of the herpes simplex virus thymidine kinase gene(HSV-tk) to sensitize tumors to the cytotoxic effects of ganciclovir administration. Previous studies using this model have focused on utilizing maximal viral titers and high levels of ganciclovir that are not compatible with human dosing. Because of the high ganciclovir doses and the maximal viral titers, this strategy has limited application to actual clinical scenarios. In the following studies the authors investigate tumor regression in an oral squamous cell carcinoma animal model as a function of variable adenoviral titers and more physiologic ganciclovir dosing. Using adenoviral titers ranging from 1 × 10⁸ to 2 × 10⁹ plaque forming units(pfu) to treat oral tumors, they found no statistical difference in tumor regression among the different viral doses, despite differences in mitotic activity. Each treatment group, however, demonstrated a significant effect on tumor regression when compared with controls. Furthermore, the authors were able to reduce the level of ganciclovir administration to 10 mg/kg twice daily from established levels of 100 to 150 mg/kg twice daily while maintaining significant tumor responses to the HSV-tk therapy. Mean survival of animals treated with this lower ganciclovir dose was significantly higher than in controls and was equal to established means based on previous studies using higher ganciclovir doses. The optimization of this suicide gene therapy strategy is imperative in order to minimize theoretical and known viral and ganciclovir toxicities while establishing a foundation upon which to design appropriate and effective clinical trials.     

萘普生对肿瘤性和感染性发热的解热作用

通过双盲法研究表明,萘普生可使肿瘤性发热很快完全消退,对感染性发热很少有解热作用。而扑热息痛对肿瘤性发热和感染性发热的解热作用与萘普生相反。萘普生、扑热息痛可用作肿瘤发热的诊断性治疗。     

Small isolated paraspinal arteriovenous fistula.

We report a case of a small, isolated paraspinal arteriovenous fistula (AVF) that arose in an adult without obvious trauma. The fistula, despite its extraspinal location and small size, caused hypertension of the intrathecal venous system and produced symptoms that were similar to those of spinal dural AVF. Detecting such a small lesion is difficult, but contrast-enhanced MR imaging can prove helpful in this regard.     

Impedance study of the electrochemical reduction of adrenochrome on glassy carbon

The electrochemical reduction of adrenochrome on a glassy carbon electrode was investigated by ac impedance in a constant ionic strength McIlvaine buffer solution. When the frequency was lower than 60 kHz, —Z″ against Z′ showed straight lines whose inclined angles with the real axis were within the range 71–76° in the diagrams of the complex impedance plane obtained at different do potentials. In the corresponding admittance diagrams, distorted semicircles appeared. The electrode reaction involves adsorption of electroactive species and the effect of concentration polarization cannot be neglected. Based upon the admittance model of the equivalent circuit, the optimal estimated values of some model parameters were obtained by using a Gauss-Newton algorithm and non-linear curve fitting. The characteristics of the electrode process are also discussed.     

H^＋—ISFET的性能特点及应用研究

本文报道由我们研制的氢离子半导体传感器的性能特点，并与普通离子选择电极（玻璃电极）比较。Ｈ＾＋－ＩＳＦＥＴ具有体积小、取样少、快速、稳定、全固体化、不用预先活化等优点，对氢离子的敏感性也优于普通玻璃电极。本文还成功地将Ｈ＾＋－ＩＳＦＥＴ应用于有复杂成分并存的尿、血及其他生物材料的ｐＨ值测试，并改进胆碱酯酶活力测定方法，将Ｈ＾＋－ＩＳＦＥＴ应用于有机磷中毒后胆碱酯酶活力的快速定量测定。     

狗前列腺微波热凝术后的组织学观察

用微波(频率2450MH_2(、单板天线(含测温装置)功率50W、中央定温60℃,进行狗前列腺热凝术。术后组织学观察,变化可分为三期:①凝固坏死期(0～3天);②炎症反应期(第6～15天);③组织自身修复期(第18～24天)。膀胱尿道造影及大体标本观察,尿道前列腺部明显扩大。提示局部、深部、温控微波热凝术,能有效地破坏前列腺组织,拓宽尿道前列腺部,而毗邻组织不受损伤。