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101.
L Jozsa M Lehto P Kannus M Kvist A Reffy T Vieno M J?rvinen S Demel E Elek 《Acta orthopaedica Scandinavica》1989,60(4):469-471
Ten intact and 22 ruptured Achilles tendons were studied by immunohistochemical techniques. In intact tendons, both fibronectin and laminin were found in vascular walls, myotendineal junction, and endomysium, but not in the connective tissue of the tendons. In ruptured tendons the distribution of laminin was not changed. Fibronectin deposits, on the contrary, could be detected on the tear surface and in the collagen fibers of the ruptured tendons. 相似文献
102.
Elina V Juhani L Tiina TJ Kari M Irma V Mauri I Harri H Esko K Hannu H Santero K Jukka V 《Journal of health organization and management》2006,20(2-3):85-94
PURPOSE: This paper describes factors influencing doctor-managers' decision making in specialised health care, health centres and at different levels of management. DESIGN/METHODOLOGY/APPROACH: Data were collected as part of a survey on physicians graduating in 1977-1991 as drawn from the register of the Finnish Medical Association. The study sample was formed by selecting all physicians born on odd days (n=4144) from the baseline group (n=8232). The category of doctor-managers comprised physicians reporting as their main occupation: principal or assistant principal physician of hospital, medical director or principal physician of health centre, senior ward physician of hospital, and health centre physician in charge of a population area. FINDINGS: Independent of gender, all doctor-managers responding to the survey reported that the most important base for decision making was personal professional experience. Position in organisation (first-line manager, principal physician) had no impact on the base of decision making. Doctor-managers in primary health care utilised knowledge on norms and knowledge available from their organisation in support of their decision making to a greater degree compared with doctor-managers in specialised health care. RESEARCH IMPLICATIONS: Evolution discourse from public administration is not yet receiving much response in Finnish doctor-managers' activities, instead, they still act as clinicians. ORIGINALITY/VALUE: Facing the growing challenges of the future, the paper shows that doctor-managers should reconstruct their orientation and to act more like managers. 相似文献
103.
Purpose The importance of induced crystal disorders like crystallite size, crystal defects, and amorphicity with respect to the dissolution
rate of the drug has been discussed in many cases. Thus, the characterization of these properties is of great importance in
the pharmaceutical formulation development, although the exact correlation between disorders and dissolution rate is still
unclear. The aim of this study was to analyze pharmaceutical tablets with grazing incidence X-ray diffraction, which enables
the depth profiling of the crystallographic properties of the tablets. To study and clarify the potential of grazing incidence
diffraction in the analysis of pharmaceutical materials, the effect of the compaction process on the surface of tablets was
examined.
Methods Carbamazepine, tolbutamide, and chlorpropamide tablets, compacted using different compression pressures, were studied using
grazing incidence angle X-ray diffraction. The effects of compression on the crystallographic properties were investigated
as a function of the distance from the tablet surface.
Results The surfaces of the tolbutamide and chlorpropamide tablets were disordered due to the compression. The manifestation of the
disorder was deduced to be due to amorphicity, small crystallite size, and amount of crystal defects. The changes were mainly
on the surface and diminished strongly as a function of the distance from the surface of the tablet. Moreover, the changes
were dependent on the compression pressure used. The changes on the surface of the carbamazepine tablets were also due to
the compression but these changes were not clearly dependent on the depth nor the compression pressure. The partial phase
transition took place in the chlorpropamide tablets due to the compression. The magnitude of the transition was not highest
on the surface because amorphization and texturization also took place on the tablet surface during the compression.
Conclusions The present study proved that grazing incidence X-ray diffraction is a potential novel research tool to reveal crystallographic
transformations taking place on the surfaces of the tablets induced, for example, by compression pressure. 相似文献
104.
105.
V P Lehto M Miettinen I Virtanen 《International journal of cancer. Journal international du cancer》1985,35(4):421-425
Intermediate filaments (IF) are ubiquitous cytoplasmic structures which, by virtue of their cell- and tissue-type-specific characteristics, are widely used as markers of tissue derivation and as differential diagnostic aids in surgical pathology. In contradistinction to other IFs, vimentin filaments, characteristic of mesenchymal cells, may be co-expressed with other cell-type specific IFs--cytokeratin filaments, desmin filaments, glial filaments and neurofilaments--in some tumor cells, embryonic cells, and cells in vitro. In this study we describe a novel type of IF co-expression which does not involve vimentin-filaments, viz. the presence of both cytokeratin filaments and neurofilaments in human bronchial carcinoid tumor cells. 相似文献
106.
M. Miettinen V.-P. Lehto P. Ekblom A. Tasanen I. Virtanen 《Journal of oral pathology & medicine》1984,13(4):373-381
A mandibular spindle-cell sarcoma originally diagnosed as malignant fibrous histiocytoma displayed a whorl-like histological structure and cellular pleomorphism. By electron microscopy the tumor cells showed prominent basal laminae around the tumor cells and bundles of myofilaments with attachment plaques. In support of the ultrastructural observations, immunofluorescence (IF) microscopy with antibodies to laminin, the major component of basal lamina, gave a bright pericellular staining of the tumor cells. IF microscopy using antibodies against intermediate filament (IMF) proteins revealed the presence of desmin, the muscle-type of IMF protein, in most tumor cells. On the other hand, staining for myoglobin was negative. The data are consistent with the diagnosis of leiomyosarcoma rather than malignant fibrous histiocytoma, and suggest that expression of desmin and laminin can be useful markers of smooth-muscle derivation of Sarcomatous tumors. 相似文献
107.
M Heikinheimo T Wahlstr?m V P Lehto U H Stenman 《The Journal of clinical endocrinology and metabolism》1985,61(1):188-191
To seek the pregnancy-specific beta 1-glycoprotein (SP1) in nonpregnant serum, normal human serum was applied to immunoadsorbent containing monoclonal anti-SP1 antibodies. SP1 eluted with 8 M urea was further analyzed by sodium dodecyl sulfate-gel electrophoresis and immunoblotting. A SP1-positive band with the same electrophoretic mobility as purified placental SP1 was found. The results suggest that serum from normal nonpregnant subjects contains material closely related to the placental protein SP1. The mean serum concentrations of SP1 were similar in men and women, ranging from 1.1-3.4 ng/ml. 相似文献
108.
109.
Thomas MC Söderlund J Lehto M Mäkinen VP Moran JL Cooper ME Forsblom C Groop PH;FinnDiane Study Group 《Diabetologia》2011,54(10):2669-2677
Aims/hypothesis
Activation of the receptor for AGE (RAGE) is implicated in the development and progression of vascular complications of diabetes. In this study, we explore factors and mortality outcomes associated with soluble RAGE (sRAGE) in a multicentre nationwide cohort of Finnish adults with type 1 diabetes. 相似文献110.